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Protein Page:
SPFH2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPFH2 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; integral to membrane
Molecular Function: protein binding
Biological Process: cell death; ER-associated protein catabolic process
Reference #:  O94905 (UniProtKB)
Alt. Names/Synonyms: C8orf2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; Erlin-2; ERLIN2; ERLN2; MGC87072; NET32; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Gene Symbols: ERLIN2
Molecular weight: 37,840 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPFH2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18-p ASSFFCAsLFsAVHK
0 1 S21-p FFCAsLFsAVHKIEE
0 1 K190-ub YELMESEkTKLLIAA
0 8 Y263-p AKADAECyTAMKIAE
0 1 T277-p EANKLKLtPEyLQLM
0 1 Y280-p KLKLtPEyLQLMKYK
0 1 Y296-p IASNSKIyFGKDIPN
0 1 S313-p MDSAGSVsKQFEGLA
0 1 T334-ga LEDEPLEtAtKEN__
0 1 T336-ga DEPLEtAtKEN____
  mouse

 
S18 ASSFFCASLFSAVHK
S21 FFCASLFSAVHKIEE
K190 YELMESEKTKLLIAA
Y263 AKADAECYTALKIAE
T277 EANKLKLTPEYLQLM
Y280 KLKLTPEYLQLMKYK
Y296 IASNSKIYFGKDIPN
G313 MDSAGGLGKQFEGLS
A335 LEDEPLEAPTKEN__
T337 DEPLEAPTKEN____
  rat

 
S18 ASSFFCASLFSAVHK
S21 FFCASLFSAVHKIEE
K190 YELMESEKTKLLIAA
Y263-p AKADAECyTALKIAE
T277 EANKLKLTPEYLQLM
Y280 KLKLTPEYLQLMKYK
Y296 IASNSKIYFGKDIPN
G313 MDSAGGLGKQSEGLS
T334 LEDEPLETATKDN__
T336 DEPLETATKDN____
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