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SPFH2 (human)

Overview SPFH2 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Endoplasmic reticulum; Membrane protein, integral Cellular Component: endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cytoplasm; plasma membrane; integral to membrane Molecular Function: protein binding Biological Process: cell death; ER-associated protein catabolic process Reference #:  O94905 (UniProtKB) Alt. Names/Synonyms: C8orf2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; Erlin-2; ERLIN2; ERLN2; MGC87072; NET32; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 Gene Symbols: ERLIN2 Molecular weight: 37,840 Da Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SPFH2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K190-u	YELMESEkTKLLIAA
0	1		S18-p	ASSFFCAsLFsAVHK
0	1		S21-p	FFCAsLFsAVHKIEE
0	7		Y263-p	AKADAECyTAMKIAE
0	1		T277-p	EANKLKLtPEyLQLM
0	1		Y280-p	KLKLtPEyLQLMKYK
0	1		Y296-p	IASNSKIyFGKDIPN
0	1		S313-p	MDSAGSVsKQFEGLA

	mouse
K190	YELMESEKTKLLIAA
S18	ASSFFCASLFSAVHK
S21	FFCASLFSAVHKIEE
Y263	AKADAECYTALKIAE
T277	EANKLKLTPEYLQLM
Y280	KLKLTPEYLQLMKYK
Y296	IASNSKIYFGKDIPN
G313	MDSAGGLGKQFEGLS

	rat
K190	YELMESEKTKLLIAA
S18	ASSFFCASLFSAVHK
S21	FFCASLFSAVHKIEE
Y263-p	AKADAECyTALKIAE
T277	EANKLKLTPEYLQLM
Y280	KLKLTPEYLQLMKYK
Y296	IASNSKIYFGKDIPN
G313	MDSAGGLGKQSEGLS

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