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WNT3A (human)

Overview WNT3A Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. Belongs to the Wnt family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; early endosome; late endosome; plasma membrane; extracellular region; lipid raft Molecular Function: protein domain specific binding; protein binding; extracellular matrix structural constituent; transcription coactivator activity; receptor agonist activity; frizzled-2 binding Biological Process: positive regulation of mesodermal cell fate specification; axon guidance; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell proliferation in forebrain; positive regulation of transcription, DNA-dependent; positive regulation of receptor internalization; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; positive regulation of collateral sprouting in the absence of injury; palate development; negative regulation of axon extension involved in axon guidance; embryonic pattern specification; notochord development; Wnt receptor signaling pathway in forebrain neuroblast division; negative regulation of neurogenesis; neuron differentiation; mammary gland development; cell-cell signaling; convergent extension; positive regulation of cell proliferation; positive regulation of B cell proliferation; heart looping; dorsoventral neural tube patterning; inner ear morphogenesis; somitogenesis; anatomical structure morphogenesis; in utero embryonic development; axis specification; hippocampus development; negative regulation of fat cell differentiation; positive regulation of peptidyl-serine phosphorylation; osteoblast differentiation; paraxial mesodermal cell fate commitment; Wnt receptor signaling pathway, calcium modulating pathway; axonogenesis; signalosome assembly; midbrain-hindbrain boundary development; spinal cord association neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry Reference #:  P56704 (UniProtKB) Alt. Names/Synonyms: MGC119418; MGC119419; MGC119420; Protein Wnt-3a; wingless-type MMTV integration site family, member 3A; WNT3A Gene Symbols: WNT3A Molecular weight: 39,365 Da Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Regulation of Microtubule Dynamics  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S65-p	NYVEIMPsVAEGIKI

	mouse
S65	NYVEIMPSVAEGVKA

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