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UBE2D2 (mouse)

Overview UBE2D2 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB. Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Ligase Molecular Function: protein binding; acid-amino acid ligase activity; ubiquitin-protein ligase activity; nucleotide binding; ATP binding; ligase activity Biological Process: protein polyubiquitination; protein ubiquitination Reference #:  P62838 (UniProtKB) Alt. Names/Synonyms: 1500034D03Rik; E2(17)KB 2; UB2D2; Ubc2e; Ubc4; Ube2d2; Ubiquitin carrier protein D2; ubiquitin conjugating enzyme 2e; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2; Ubiquitin-protein ligase D2 Gene Symbols: Ube2d2 Molecular weight: 16,735 Da Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling

Select Structure to View Below UBE2D2 1UR6 - A=1-147 (human) 1W4U - A=1-147 (human) 2C4O - A/B/C/D=1-147 (human) 2CLW - A/B/C/D=1-147 (human) 2ESK - A=1-147 (human) 2ESO - A=1-147 (human) 2ESP - A=1-147 (human) 2ESQ - A=1-147 (human) 3L1Y - A=1-147 (human) 3TGD - A=1-147 (human) 4A49 - B=1-147 (human) 4A4B - C=1-147 (human) 4A4C - C=1-147 (human) 4AUQ - A/D=1-147 (human) 4DDG - H/N/C/D/R/V=1-147 (human) 4DDI - F/D/E=1-147 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		K8	MALKRIHKELNDLAR
0	4		K8-u	MALKRIHkELNDLAR
0	2		S83-p	PNINSNGsICLDILR
0	1		K101	SPALTISKVLLSICS
0	13		K128-u	PEIARIYkTDREKYN
0	58		K144-u	IAREWTQkYAM____
0	2		Y145	AREWTQkYAM_____

	human
K8-a	MALKRIHkELNDLAR
K8-u	MALKRIHkELNDLAR
S83	PNINSNGSICLDILR
K101-u	SPALTISkVLLSICS
K128-u	PEIARIYkTDREKYN
K144-u	IAREWTQkyAM____
Y145-p	AREWTQkyAM_____

	rat
K8	MALKRIHKELNDLAR
K8	MALKRIHKELNDLAR
S83	PNINSNGSICLDILR
K101	SPALTISKVLLSICS
K128	PEIARIYKTDREKYN
K144	IAREWTQKYAM____
Y145	AREWTQKYAM_____

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