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Protein Page:
UBE2D2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE2D2 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase
Cellular Component: protein complex; ubiquitin ligase complex
Molecular Function: protein binding; acid-amino acid ligase activity; ubiquitin-protein ligase activity; nucleotide binding; ATP binding; ligase activity
Biological Process: protein polyubiquitination; protein ubiquitination
Reference #:  P62838 (UniProtKB)
Alt. Names/Synonyms: 1500034D03Rik; E2(17)KB 2; UB2D2; Ubc2e; Ubc4; Ube2d2; Ubiquitin carrier protein D2; ubiquitin conjugating enzyme 2e; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2; Ubiquitin-protein ligase D2
Gene Symbols: Ube2d2
Molecular weight: 16,735 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below

UBE2D2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K8 MALKRIHKELNDLAR
0 4 K8-ub MALKRIHkELNDLAR
0 2 S83-p PNINSNGsICLDILR
0 2 T98 SQWSPALTISKVLLS
0 1 K101 SPALTISKVLLSICS
0 13 K128-ub PEIARIYkTDREKYN
0 58 K144-ub IAREWTQkYAM____
  human

 
K8-ac MALKRIHkELNDLAR
K8-ub MALKRIHkELNDLAR
S83 PNINSNGSICLDILR
T98-p SQWSPALtISkVLLS
K101-ub SPALtISkVLLSICS
K128-ub PEIARIYkTDREKYN
K144-ub IAREWTQkYAM____
  rat

 
K8 MALKRIHKELNDLAR
K8 MALKRIHKELNDLAR
S83 PNINSNGSICLDILR
T98-p SQWSPALtISKVLLS
K101 SPALtISKVLLSICS
K128 PEIARIYKTDREKYN
K144 IAREWTQKYAM____
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