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Protein Page:
IRF6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRF6 Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 1q32.3-q41
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: keratinocyte differentiation; negative regulation of cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; keratinocyte proliferation; cell cycle arrest; cell development
Reference #:  O14896 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 6; IRF-6; IRF6; LPS; OFC6; PIT; PPS; VWS
Gene Symbols: IRF6
Molecular weight: 53,130 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRF6

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S413‑p, S424‑p
activity, induced: S413‑p, S424‑p
protein conformation: S413‑p, S424‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T44 QIPWKHATRHSPQQE
0 1 K66-ub AWAVETGkYQEGVDD
0 1 Y97-p SREFNLMyDGTKEVP
0 1 S244 YGQTMTVSNPQGCRL
0 2 Y312-p EVSGHAIyAIRLCQC
2 1 S413-p FSGDFTRsFDsGSVR
0 1 S416-p DFTRsFDsGSVRLQI
2 1 S424-p GSVRLQIsTPDIKDN
0 1 S457-p QPMQPTPsMQLPPAL
  mouse

 
T44-p QIPWKHAtRHSPQQE
K66 AWAVETGKYQEGVDD
Y97 SREFNLMYDGTKEVP
S244-p YGQTMTVsNPQGCRL
Y312 EVSGHAIYAIRLCQC
S413 FSGDFTRSFDSGSVR
S416 DFTRSFDSGSVRLQI
S424 GSVRLQISTPDIKDN
S457 QPMQPAPSMQLPQAL
  rat

 
T44 QIPWKHATRHSPQQE
K66 AWAVETGKYQEGVDD
Y97 SREFNLMYDGTKEVP
S244 YGQTMTVSNPQGCRL
Y312 EVSGHAIYAIRLCQC
S413 FSGDFTRSFDSGSVR
S416 DFTRSFDSGSVRLQI
S424-p GSVRLQIsTPDIKDN
S457 QPMQPAPSMQLPPAL
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