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IRF6 (human)

Overview IRF6 Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: cytoplasm; nucleus; cytosol Molecular Function: protein binding; DNA binding; transcription factor activity Biological Process: keratinocyte differentiation; skin development; negative regulation of cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; keratinocyte proliferation; cell cycle arrest; cell development Reference #:  O14896 (UniProtKB) Alt. Names/Synonyms: Interferon regulatory factor 6; IRF-6; IRF6; LPS; OFC6; PIT; PPS; VWS Gene Symbols: IRF6 Molecular weight: 53,130 Da Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRF6

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 119300 119500 607199 608864  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T44	QIPWKHATRHSPQQE
0	1		K66-u	AWAVETGkYQEGVDD
0	1		Y97-p	SREFNLMyDGTKEVP
0	1		S244	YGQTMTVSNPQGCRL
0	2		Y312-p	EVSGHAIyAIRLCQC
0	1		S413-p	FSGDFTRsFDsGSVR
0	1		S416-p	DFTRsFDsGSVRLQI
0	1		S457-p	QPMQPTPsMQLPPAL

	mouse
T44-p	QIPWKHAtRHSPQQE
K66	AWAVETGKYQEGVDD
Y97	SREFNLMYDGTKEVP
S244-p	YGQTMTVsNPQGCRL
Y312	EVSGHAIYAIRLCQC
S413	FSGDFTRSFDSGSVR
S416	DFTRSFDSGSVRLQI
S457	QPMQPAPSMQLPQAL

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