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Protein Page:
SMPD1 (human)

SMPD1 Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. Monomer. Belongs to the acid sphingomyelinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - sphingolipid; Phosphodiesterase; EC
Chromosomal Location of Human Ortholog: 11p15.4-p15.1
Cellular Component: lysosomal lumen; extracellular space; lysosome; plasma membrane; endosome; lamellar body
Molecular Function: protein binding; sphingomyelin phosphodiesterase activity; hydrolase activity, acting on glycosyl bonds
Biological Process: response to drug; nervous system development; negative regulation of MAP kinase activity; sphingolipid metabolic process; sphingomyelin metabolic process; positive regulation of apoptosis; ceramide biosynthetic process; glycosphingolipid metabolic process; sphingomyelin catabolic process; signal transduction; response to cocaine; positive regulation of protein amino acid dephosphorylation
Disease: Niemann-pick Disease, Type B; Niemann-pick Disease, Type A
Reference #:  P17405 (UniProtKB)
Alt. Names/Synonyms: Acid sphingomyelinase; ASM; aSMase; NPD; SMPD1; Sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbols: SMPD1
Molecular weight: 69,752 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Sites Implicated In
enzymatic activity, induced: S508‑p
intracellular localization: S508‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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