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SMPD1 (human)

Overview SMPD1 Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. Monomer. Belongs to the acid sphingomyelinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - sphingolipid; EC 3.1.4.12; Phosphodiesterase Cellular Component: extracellular space; lysosomal lumen; lamellar body Molecular Function: sphingomyelin phosphodiesterase activity; hydrolase activity, acting on glycosyl bonds Biological Process: cell death; response to drug; nervous system development; negative regulation of MAP kinase activity; sphingolipid metabolic process; sphingomyelin metabolic process; positive regulation of apoptosis; response to cocaine; signal transduction; positive regulation of protein amino acid dephosphorylation; phospholipid metabolic process; ceramide biosynthetic process; glycosphingolipid metabolic process; sphingomyelin catabolic process Reference #:  P17405 (UniProtKB) Alt. Names/Synonyms: Acid sphingomyelinase; ASM; aSMase; NPD; SMPD1; Sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase 1, acid lysosomal Gene Symbols: SMPD1 Molecular weight: 69,752 Da Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SMPD1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 257200 607608 607616  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S508‑p intracellular localization: S508‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		S508-p	DGNYSGSsHVVLDHE

	mouse
S506	DGNYPGSSHVVLDHE

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