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Protein Page:
SMARCB1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SMARCB1 a core component of the BAF (hSWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Binds to double-stranded DNA. Interacts with EphB4 and MAEL. Interacts with GADD34. Binds tightly to the human immunodeficiency virus-type 1 (HIV-1) integrase in vitro and stimulates its DNA-joining activity. Interacts with human papillomavirus 18 E1 protein to stimulates its viral replication. Belongs to the SNF5 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Cell cycle regulation
Cellular Component: nucleoplasm; XY body; SWI/SNF complex; protein complex; nuclear chromatin; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; p53 binding; Tat protein binding; transcription coactivator activity
Biological Process: nervous system development; transcription, DNA-dependent; DNA integration; DNA repair; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; negative regulation of cell proliferation; nucleosome disassembly; blastocyst hatching; ATP-dependent chromatin remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; cell differentiation
Reference #:  Q12824 (UniProtKB)
Alt. Names/Synonyms: BAF47; BRG1-associated factor 47; hSNF5; hSNFS; INI1; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; RDT; RTPS1; Sfh1p; SMARCB1; SNF5; SNF5 homolog; SNF5L1; Snr1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Gene Symbols: SMARCB1
Molecular weight: 44,141 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SMARCB1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S49-p SLYKRYPsLWRRLAT
0 1 S7-p _MMMMALsKTFGQKP
0 1 K8 MMMMALsKTFGQKPV
0 1 K106-u ILDGNDEkYKAVSIS
0 2 S129-p EQKAKRNsQWVPtLP
0 6 T134-p RNsQWVPtLPNSSHH
0 1 K199-u DMEIDGQkLRDAFTW
0 1 K292-u EKENSPEkFALKLCS
  SMARCB1 iso2  
S49 SLYKRYPSLWRRLAT
S7 _MMMMALSKTFGQKP
K8 MMMMALSKTFGQKPV
K97 ILDGNDEKYKAVSIS
S120 EQKAKRNSQWVPTLP
T125 RNSQWVPTLPNSSHH
K190 DMEIDGQKLRDAFTW
K283 EKENSPEKFALKLCS
  mouse

 
S49 SLYKRYPSLWRRLAT
S7 _MMMMALSkTFGQKP
K8-u MMMMALSkTFGQKPV
K106 ILDGNDEKYKAVSIS
S129 EQKAKRNSQWVPtLP
T134-p RNSQWVPtLPNSSHH
K199 DMEIDGQKLRDAFTW
K292 EKENSPEKFALKLCS
  rat

 
S49 SLYKRYPSLWRRLAT
S7 _MMMMALSKTFGQKP
K8 MMMMALSKTFGQKPV
K97 ILDGNDEKYKAVSIS
S120 EQKAKRNSQWVPTLP
T125 RNSQWVPTLPNSSHH
K190 DMEIDGQKLRDAFTW
K283 EKENSPEKFALKLCS
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