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Cdc42 iso1
a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; G protein, monomeric (Rho); G protein |
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Cellular Component: Golgi membrane; neuron projection; cell soma; apical part of cell; cytoplasm; plasma membrane; microtubule organizing center; spindle midzone; midbody; cytosol; filopodium; secretory granule
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Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding; GTP-dependent protein binding; thioesterase binding; mitogen-activated protein kinase kinase kinase binding; apolipoprotein A-I receptor binding; protein kinase binding
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Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; regulation of protein heterodimerization activity; macrophage differentiation; filopodium formation; establishment and/or maintenance of cell polarity; regulation of protein stability; positive regulation of JNK cascade; regulation of filopodium formation; Wnt receptor signaling pathway through beta-catenin; GTP catabolic process; establishment of Golgi localization; keratinization; small GTPase mediated signal transduction; regulation of mitosis; Golgi organization and biogenesis; neuron fate determination; epidermal growth factor receptor signaling pathway; actin filament bundle formation; regulation of attachment of spindle microtubules to kinetochore; hair follicle morphogenesis; multicellular organism growth; positive regulation of phosphoinositide 3-kinase activity; establishment and/or maintenance of apical/basal cell polarity; positive regulation of peptidyl-serine phosphorylation; muscle cell differentiation; regulation of small GTPase mediated signal transduction; positive regulation of pseudopodium formation; heart contraction; T cell costimulation; positive regulation of muscle cell differentiation; regulation of protein catabolic process; regulation of protein kinase activity; blood coagulation; actin cytoskeleton organization and biogenesis; negative regulation of protein complex assembly; nuclear migration; positive regulation of DNA replication
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Reference #:
P60953-1 (UniProtKB)
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| Alt. Names/Synonyms: CDC42; CDC42Hs; Cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP-binding protein, 25kD; small GTP binding protein CDC42 |
| Gene Symbols: CDC42 |
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Molecular weight: 21,311 Da
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Basal Isoelectric point: 5.76
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Regulation of Actin Dynamics
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Regulation of Microtubule Dynamics
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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