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Protein Page:
LAMP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LAMP1 Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to plasma membrane; lysosome; lysosomal membrane; dendrite; multivesicular body; membrane; cell soma; cytoplasm; late endosome; melanosome; endosome membrane; sarcolemma; external side of plasma membrane
Molecular Function: protein binding; enzyme binding
Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; protein stabilization; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity
Reference #:  P11279 (UniProtKB)
Alt. Names/Synonyms: CD107 antigen-like family member A; CD107a; LAMP-1; LAMP1; LAMPA; LGP120; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1
Gene Symbols: LAMP1
Molecular weight: 44,882 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LAMP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S69-p NMTFDLPsDAtVVLN
0 1 T72-p FDLPsDAtVVLNRss
0 1 S78-p AtVVLNRssCGKENt
0 1 S79-p tVVLNRssCGKENtS
0 1 T85-p ssCGKENtSDPSLVI
0 1 S197-ga RCEQDRPsPttAPPA
0 1 T199-ga EQDRPsPttAPPAPP
0 1 T200-ga QDRPsPttAPPAPPs
0 1 S207-ga tAPPAPPsPsPsPVP
0 1 S209-ga PPAPPsPsPsPVPKS
0 1 S211-ga APPsPsPsPVPKSPS
0 1 K319-u DARDPAFkAANGSLR
0 1 T331-ga SLRALQAtVGNSyKC
0 3 Y336-p QAtVGNSyKCNAEEH
0 1 S351-p VRVTKAFsVNIFKVW
0 11 Y414-p RKRSHAGyQTI____
  mouse

 
- gap
- gap
S72 AEVLKNGSSCGKENV
S73 EVLKNGSSCGKENVS
V79 SSCGKENVSDPSLTI
S191 HCTQDGPSPTTGPPS
T193 TQDGPSPTTGPPSPS
T194 QDGPSPTTGPPSPSP
S198 SPTTGPPSPSPPLVP
S200 TTGPPSPSPPLVPTN
P202 GPPSPSPPLVPTNPT
S308 DALVPTFSISNHSLK
T320 SLKALQATVGNSYKC
Y325 QATVGNSYKCNTEEH
S340 IFVSKMLSLNVFSVQ
Y403 RKRSHAGYQTI____
  rat

 
- gap
- gap
S73 AEVLKNSSSCGEKNA
S74 EVLKNSSSCGEKNAS
A80 SSCGEKNASEPTLAI
S192 RCPQDQPSPTTGPPS
T194 PQDQPSPTTGPPSPS
T195 QDQPSPTTGPPSPSP
S199 SPTTGPPSPSPPLVP
S201 TTGPPSPSPPLVPTN
P203 GPPSPSPPLVPTNPS
S309 DAIEPTFSTSNYSLK
S321 SLKALQASVGNSYKC
Y326 QASVGNSYKCNSEEH
A341 IFVSKALALNVFSVQ
Y404 RKRSHAGYQTI____
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