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Protein Page:
KRT6B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KRT6B Defects in KRT6B are a cause of pachyonychia congenita type 2 (PC2); also known as pachyonychia congenita Jackson-Lawler type. PC2 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: keratin filament
Molecular Function: structural constituent of cytoskeleton
Biological Process: ectoderm development
Reference #:  P04259 (UniProtKB)
Alt. Names/Synonyms: CK-6B; CK6B; cytokeratin 6B; Cytokeratin-6B; K2C6B; K6B; keratin 6B; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 6B; Keratin-6B; keratin-like 1 (a type II keratin sequence); KRT6B; KRTL1; PC2; Type-II keratin Kb10
Gene Symbols: KRT6B
Molecular weight: 60,067 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KRT6B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 188 Y62-p GFGSRSLyGLGGSKR
0 142 Y83-p SCAISGGyGSRAGGS
0 3 K168-ub AEEREQIkTLNNkFA
0 30 K173-ac QIkTLNNkFAsFIDk
0 8 K173-ub QIkTLNNkFAsFIDk
0 18 S176-p TLNNkFAsFIDkVRF
0 6 K180-ac kFAsFIDkVRFLEQQ
0 8 K180-ub kFAsFIDkVRFLEQQ
0 54 Y278-p KKDVDAAyMNKVELQ
0 92 Y341-p IAEVKAQyEEIAQRS
0 8 Y356-p RAEAESWyQTKyEEL
0 32 Y360-p ESWyQTKyEELQITA
0 1 K426-ac ALKDAKNkLEGLEDA
0 5 S540-p RATGGGLssVGGGSS
0 4 S541-p ATGGGLssVGGGSSt
0 1 T548-p sVGGGSStIKyTTTS
0 2 Y551-p GGSStIKyTTTSSSS
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