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KRT6B (human)

Overview KRT6B Defects in KRT6B are a cause of pachyonychia congenita type 2 (PC2); also known as pachyonychia congenita Jackson-Lawler type. PC2 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: keratin filament Molecular Function: structural constituent of cytoskeleton Biological Process: ectoderm development Reference #:  P04259 (UniProtKB) Alt. Names/Synonyms: CK-6B; CK6B; cytokeratin 6B; Cytokeratin-6B; K2C6B; K6B; keratin 6B; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 6B; Keratin-6B; keratin-like 1 (a type II keratin sequence); KRT6B; KRTL1; PC2; Type-II keratin Kb10 Gene Symbols: KRT6B Molecular weight: 60,067 Da Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states

Select Structure to View Below KRT6B

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 148042 167210  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	188		Y62-p	GFGSRSLyGLGGSKR
0	142		Y83-p	SCAISGGyGSRAGGS
0	3		K168-u	AEEREQIkTLNNkFA
1	29		K173-a	QIkTLNNkFASFIDk
0	8		K173-u	QIkTLNNkFASFIDk
0	6		K180-a	kFASFIDkVRFLEQQ
0	8		K180-u	kFASFIDkVRFLEQQ
0	54		Y278-p	KKDVDAAyMNKVELQ
0	92		Y341-p	IAEVKAQyEEIAQRS
0	8		Y356-p	RAEAESWyQTKyEEL
0	32		Y360-p	ESWyQTKyEELQITA
0	1		K426-a	ALKDAKNkLEGLEDA
0	1		Y465-p	LDVEIATyRKLLEGE
0	5		S540-p	RATGGGLssVGGGSS
0	4		S541-p	ATGGGLssVGGGSSt
0	1		T548-p	sVGGGSStIKyTTTS
0	2		Y551-p	GGSStIKyTTTSSSS

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