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Protein Page:
CD36 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD36 Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion
Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; lipid raft; external side of plasma membrane
Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding
Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; sequestering of lipid; antigen processing and presentation of peptide antigen via MHC class I; cell surface receptor linked signal transduction; platelet degranulation; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell adhesion; positive regulation of cell-matrix adhesion; toll-like receptor 4 signaling pathway; platelet activation; receptor-mediated endocytosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; cholesterol transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; positive regulation of phagocytosis, engulfment; blood coagulation; nitric oxide mediated signal transduction; plasma membrane long-chain fatty acid transport; apoptotic cell clearance
Reference #:  P16671 (UniProtKB)
Alt. Names/Synonyms: CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); CHDS7; cluster determinant 36; FAT; Fatty acid translocase; Glycoprotein IIIb; GP3B; GP4; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; PASIV; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; SCARB3; scavenger receptor class B, member 3; Thrombospondin receptor
Gene Symbols: CD36
Molecular weight: 53,053 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Select Structure to View Below

CD36

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K56 IAFKNWVKtGTEVyR
0 1 T57-p AFKNWVKtGTEVyRQ
0 1 Y62-p VKtGTEVyRQFWIFD
1 0 T92-p VKQRGPYtYRVRFLA
0 2 K298-ac YRFVLPSkAFASPVE
0 1 T323-p KIISKNCtSYGVLDI
0 1 K385 GFTLQFAKRLQVNLL
1 0 K469-ub SYCACRSkTIk____
1 0 K472-ub ACRSkTIk_______
  mouse

 
K56-ub TAFKNWVkTGTTVYR
T57 AFKNWVkTGTTVYRQ
Y62 VkTGTTVYRQFWIFD
T92 VKQRGPYTYRVRYLA
N298 YRFVLPANAFASPLQ
T323 KVISNNCTSYGVLDI
K385-ac GFTLQFAkRLQVNIL
K469 SYCACKSKNGK____
K472 ACKSKNGK_______
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