Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CD36 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD36 Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q11.2
Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft
Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; lipid binding; high-density lipoprotein binding
Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; antigen processing and presentation of peptide antigen via MHC class I; sequestering of lipid; platelet degranulation; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; positive regulation of cell-matrix adhesion; cell adhesion; toll-like receptor 4 signaling pathway; receptor-mediated endocytosis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; cholesterol transport; positive regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; blood coagulation; positive regulation of phagocytosis, engulfment; plasma membrane long-chain fatty acid transport; nitric oxide mediated signal transduction; apoptotic cell clearance
Disease: Platelet Glycoprotein Iv Deficiency; Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To
Reference #:  P16671 (UniProtKB)
Alt. Names/Synonyms: CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); CHDS7; cluster determinant 36; FAT; Fatty acid translocase; Glycoprotein IIIb; GP3B; GP4; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; PASIV; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; SCARB3; scavenger receptor class B, member 3; Thrombospondin receptor
Gene Symbols: CD36
Molecular weight: 53,053 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD36

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K52 EEGTIAFKNWVKtGT
0 1 K56 IAFKNWVKtGTEVyR
0 1 K56 IAFKNWVKtGTEVyR
0 1 T57-p AFKNWVKtGTEVyRQ
0 1 Y62-p VKtGTEVyRQFWIFD
1 0 T92-p VKQRGPYtYRVRFLA
0 1 K166 NSLINKSKSSMFQVR
0 2 K298-ac YRFVLPSkAFASPVE
0 1 T323-p KIISKNCtSYGVLDI
0 1 R337 ISKCKEGRPVYISLP
0 1 K385 GFTLQFAKRLQVNLL
0 1 K394 LQVNLLVKPSEKIQV
0 1 K398 LLVKPSEKIQVLKNL
0 1 K403 SEKIQVLKNLKRNYI
1 0 K469-ub SYCACRSkTIk____
1 0 K472-ub ACRSkTIk_______
  mouse

 
K52 EEGTTAFKNWVkTGT
K56 TAFKNWVKTGTTVYR
K56-ub TAFKNWVkTGTTVYR
T57 AFKNWVkTGTTVYRQ
Y62 VkTGTTVYRQFWIFD
T92 VKQRGPYTYRVRYLA
K166 NSLIKKSKSSMFQTR
N298 YRFVLPANAFASPLQ
T323 KVISNNCTSYGVLDI
K337 IGKCKEGKPVYISLP
K385-ac GFTLQFAkRLQVNIL
K394 LQVNILVKPARKIEA
K398 ILVKPARKIEALKNL
K403 ARKIEALKNLKRPYI
K469 SYCACKSKNGK____
K472 ACKSKNGK_______
  rat

 
K52-ac EEGTIAFkNWVkTGT
K56-ac IAFkNWVkTGTTVYR
K56 IAFkNWVKTGTTVYR
T57 AFkNWVkTGTTVYRQ
Y62 VkTGTTVYRQFWIFD
T92 VKQRGPYTYRVRYLA
K166-ac NSLIKKSkSSMFQTR
N298 YRFVLPANAFASPLQ
T323 KVISNNCTSYGVLDI
K337-ac IGKCKEGkPVYISLP
K385 GFTLQFAKRLQVNIL
K394-ac LQVNILVkPARkIEA
K398-ac ILVkPARkIEALkNL
K403-ac ARkIEALkNLKRPYI
K469 SYCACRSKNGK____
K472 ACRSKNGK_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.