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Protein Page:
MTMR14 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MTMR14 Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.-
Chromosomal Location of Human Ortholog: 3p26
Cellular Component: ruffle; perinuclear region of cytoplasm; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity
Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process
Reference #:  Q8NCE2 (UniProtKB)
Alt. Names/Synonyms: C3orf29; egg-derived tyrosine phosphatase homolog; FLJ11546; FLJ22405; FLJ46453; FLJ90311; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; hJumpy; jumpy; MTMR14; MTMRE; myotubularin related protein 14; Myotubularin-related protein 14; NS5ATP4ABP1
Gene Symbols: MTMR14
Molecular weight: 72,203 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MTMR14

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S47-p QYRAKDGsGtGGsKV
0 1 T49-p RAKDGsGtGGsKVER
0 1 S52-p DGsGtGGsKVERIEK
0 2 Y154-p LAGWGELyGRSGYNY
0 1 K194-ac GDTHLFDkVRGYDIK
0 1 Y210-p LRYLSVKyICDLMVE
0 2 K409-ub SEEFSALkTQRRKsL
0 16 S415-p LkTQRRKsLPARDGG
0 1 Y462-p GATGSFTyEAVELVP
0 2 S485-p WRKSHSSsPQSVLWN
0 1 S503-p PSEDRLPsQQGLAEA
0 1 S514-p LAEARSSsSSssNHS
0 1 S517-p ARSSsSSssNHSDNF
0 1 S518-p RSSsSSssNHSDNFF
0 5 S529-p DNFFRMGssPLEVPK
0 8 S530-p NFFRMGssPLEVPKP
0 1 S539-p LEVPKPRsVDHPLPG
0 2 S555-p SLSTDYGsWQMVTGC
0 2 S576-p AVLHTDSsLPFsFPD
0 6 S580-p TDSsLPFsFPDELPN
0 1 S606-p TRLQEVRsAFLAAYs
0 1 S613-p sAFLAAYsStVGLRA
0 1 T615-p FLAAYsStVGLRAVA
0 8 S624-p GLRAVAPsPSGAIGG
0 1 S626 RAVAPsPSGAIGGLL
0 2 R638-m1 GLLEQFArGVGLRsI
0 4 S644-p ArGVGLRsISSNAL_
  mouse

 
G46 QYRAKDSGGKSGSKV
K48 RAKDSGGKSGSKVER
S51 DSGGKSGSKVERIEK
Y153 LAGWGELYGRSGYNY
K193 GDTHLFDKVRGYDIK
Y209 LQYLSVKYICDLMVE
K407 TSEEFCLKTQRRKSL
S413 LKTQRRKSLPTRDAG
Y460 GAVGSFSYETVELAP
S483 WRKSHSSSPQSMLWS
S501 PSEERLPSHHGLTEA
S512 LTEAKSSSSSSSNHS
S515 AKSSSSSSSNHSDNF
S516 KSSSSSSSNHSDNFF
S527 DNFFRMGSsPLEVPK
S528-p NFFRMGSsPLEVPKP
S537 LEVPKPRSVDHPLPG
S553 SLSTDFGSWQLVSGC
S574 PVLHTDSSLPFSFQD
S578 TDSSLPFSFQDELPN
S604 TRLQEVRSAFLAAYS
S611 SAFLAAYSSTVGLRA
T613 FLAAYSSTVGLRAAT
S622-p GLRAATPsPsGAIGG
S624-p RAATPsPsGAIGGLL
R636 GLLEQFARGVGLRGT
G642 ARGVGLRGTSTSTL_
  rat

 
G46 QYRAKDSGGKSGSKV
K48 RAKDSGGKSGSKVEL
S51 DSGGKSGSKVELIEK
Y153 LAGWGELYGRSGYNY
K193 GDTHLFDKVRGYDIK
Y209 LQYLSVKYICDLMVE
K407 TSEEFCLKTQRRKSL
S413 LKTQRRKSLPTRDAG
Y460 GAVGSFSYEAVELVP
S483 WRKSHSSSPQSMLWS
S501 PSDDRLPSHHGFTEA
S512 FTEAKSSSSSSSNHS
S515 AKSSSSSSSNHSDNF
S516 KSSSSSSSNHSDNFF
S527 DNFFRMGSSPLEVPK
S528 NFFRMGSSPLEVPKP
S537 LEVPKPRSVDHPLPG
S553 SLSTDFGSWQMVSGC
S574 PVLHTDSSLPFSFQD
S578 TDSSLPFSFQDELPN
S604 TRLQEVRSAFLAAYS
S611 SAFLAAYSSTVRLRA
T613 FLAAYSSTVRLRAAA
S622-p RLRAAAPsPSGAIGG
S624 RAAAPsPSGAIGGLL
R636 GLLEQFARGVGLRGT
G642 ARGVGLRGTSTSAL_
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