Home

Myt1 (human)

Overview Myt1 a dual specificity protein kinase of the WEE family. Preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Alternative splice-variant isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Protein kinase, dual-specificity; Kinase, protein; Protein kinase, Other; Other group; WEE family Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; kinase activity; ATP binding; protein kinase activity Biological Process: mitosis; regulation of cell cycle; regulation of mitosis; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle Reference #:  Q99640 (UniProtKB) Alt. Names/Synonyms: DKFZp547K1610; FLJ20093; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT1; PMYT1; protein kinase Myt1; protein kinase, membrane associated tyrosine/threonine 1 Gene Symbols: PKMYT1 Molecular weight: 54,521 Da Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G2/M DNA Damage Checkpoint  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Myt1 3P1A - A=75-362 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: T412‑p, S416‑p, S441‑p, T455‑p, T461‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		T17-p	MPMPTEGtPPPLSGT
0	2		S40-p	RHAEPGFsLKRPRGL
0	1		S48-p	LKRPRGLsRsLPPPP
0	2		S50-p	RPRGLsRsLPPPPPA
0	10		T71-p	SRLFPPRtPGWHQLQ
1	0		S83	QLQPRRVSFRGEASE
0	3		S94-p	EASETLQsPGYDPSR
0	3		S120-p	LSRLGHGsYGEVFkV
0	1		K126-u	GsYGEVFkVRSKEDG
0	1		Y136-p	SKEDGRLyAVKRsMs
0	1		S141-p	RLyAVKRsMsPFRGP
0	10		S143-p	yAVKRsMsPFRGPkD
0	1		K149-u	MsPFRGPkDRARkLA
0	3		K154-u	GPkDRARkLAEVGsH
0	2		S160-p	RkLAEVGsHEkVGQH
0	1		K163-u	AEVGsHEkVGQHPCC
1	0		T412-p	QPLGPPAtPPGsPPC
1	0		S416-p	PPAtPPGsPPCSLLL
1	0		S426-p	CSLLLDSsLSSNWDD
1	0		S441-p	DSLGPSLsPEAVLAR
0	1		S454-p	ARTVGSTstPRsRCt
1	7		T455-p	RTVGSTstPRsRCtP
0	1		S458-p	GSTstPRsRCtPRDA
1	0		T461-p	stPRsRCtPRDALDL
0	3		S469-p	PRDALDLsDINsEPP
0	1		S473-p	LDLsDINsEPPRGsF
0	1		S479-p	NsEPPRGsFPSFEPR
2	3		T495-p	LLSLFEDtLDPT___

	mouse
T8	MTMPTEGTPPPLSGT
S31	RHAEPGFSLKRPGGL
S39	LKRPGGLSRSLPPRP
S41	RPGGLSRSLPPRPPA
T62	SRLFPPRTPGWHQPQ
S74	QPQPRRVSFLCETSE
S85	ETSEPLQSPGYDPSR
S111	LSRLGHGSYGEVFKV
K117	GSYGEVFKVRSKEDG
Y127	SKEDGRLYAVKRYMs
Y132	RLYAVKRYMsPFRGP
S134-p	YAVKRYMsPFRGPKD
K140	MsPFRGPKDRTRKLA
K145	GPKDRTRKLAEVGGH
G151	RKLAEVGGHEKVGQH
K154	AEVGGHEKVGQHPHC
T403	QPPGPPATPPGSPPC
S407	PPATPPGSPPCSPLL
T417	CSPLLDSTLSSSWDN
S432	DSIGPSLSPETVLSR
S445	SRITRRTSTPRGRYI
T446	RITRRTSTPRGRYIP
G449	RRTSTPRGRYIPRDA
I452	STPRGRYIPRDALDL
T460	PRDALDLTDVDSEPP
S464	LDLTDVDSEPPRGPC
P470	DSEPPRGPCPTFEPR
S486	LLSLFEDSLDPA___

	starfish
S8	MQSDFESSLRENGFR
S31	LQEQVTFSQKKHRGT
T39	QKKHRGTTPRRTGPP
T43	RGTTPRRTGPPRPPL
T64	SRLFPNKTREEESRP
S75-p	ESRPRAVsFRQSEPS
S86	SEPSVLQSPHYNEKS
S112	VQKLGEGSFGEVYKV
K118	GSFGEVYKVKCKEDD
Y128	CKEDDKFYAVKRSRE
S133	KFYAVKRSRERFKGE
E135	YAVKRSRERFKGEAD
A141	RERFKGEADRKRKLE
K146	GEADRKRKLEEVHQH
Q152	RKLEEVHQHETLSRH
T155	EEVHQHETLSRHPNC
T419	PLTGISATPTTKCFD
-	gap
-	gap
S462	PASYPVISTSGTPLL
-	gap
-	gap
S483	TPLHQPRSSSPICHG
T500	NNSFDRWTPNGSPNI
S508	PNGSPNISAVHDDPA
-	gap
-	gap
T545	LMQIFEDTDDN____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.