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Protein Page:
Myt1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Myt1 a dual specificity protein kinase of the WEE family. Preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Alternative splice-variant isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, dual-specificity (non-receptor); Other group; WEE family
Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; kinase activity; ATP binding; protein kinase activity
Biological Process: mitosis; regulation of cell cycle; regulation of mitosis; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle
Reference #:  Q99640 (UniProtKB)
Alt. Names/Synonyms: DKFZp547K1610; FLJ20093; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT1; PMYT1; protein kinase Myt1; protein kinase, membrane associated tyrosine/threonine 1
Gene Symbols: PKMYT1
Molecular weight: 54,521 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Myt1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T412‑p, S416‑p, S441‑p, T455‑p, T461‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 T17-p MPMPTEGtPPPLSGt
0 2 T24-p tPPPLSGtPIPVPAY
0 8 S40-p RHAEPGFsLKRPRGL
0 1 S48-p LKRPRGLsRsLPPPP
0 5 S50-p RPRGLsRsLPPPPPA
0 1 S60-p PPPPAKGsIPIsRLF
0 1 S64-p AKGsIPIsRLFPPRt
0 10 T71-p sRLFPPRtPGWHQLQ
1 0 S83 QLQPRRVSFRGEAsE
0 1 S89-p VSFRGEAsETLQsPG
0 5 S94-p EAsETLQsPGyDPSR
0 1 Y97-p ETLQsPGyDPSRPES
0 1 S109-p PESFFQQsFQRLSRL
0 6 S120-p LSRLGHGsYGEVFkV
0 1 K126-ub GsYGEVFkVRSKEDG
0 3 S141-p RLYAVKRsMsPFRGP
0 14 S143-p YAVKRsMsPFRGPkD
0 1 K149-ub MsPFRGPkDRARkLA
0 3 K154-ub GPkDRARkLAEVGsH
0 4 S160-p RkLAEVGsHEkVGQH
0 1 K163-ub AEVGsHEkVGQHPCC
1 0 T412-p QPLGPPAtPPGsPPC
1 0 S416-p PPAtPPGsPPCSLLL
1 0 S426-p CSLLLDSsLSSNWDD
1 0 S441-p DSLGPSLsPEAVLAR
0 1 T453-p LARTVGStstPRsRC
0 2 S454-p ARTVGStstPRsRCt
1 7 T455-p RTVGStstPRsRCtP
0 1 S458-p GStstPRsRCtPRDA
1 0 T461-p stPRsRCtPRDALDL
0 6 S469-p PRDALDLsDINsEPP
0 2 S473-p LDLsDINsEPPRGsF
0 4 S479-p NsEPPRGsFPsFEPR
0 2 S482-p PPRGsFPsFEPRNLL
2 3 T495-p LLSLFEDtLDPT___
4281 : Phospho-Myt1 (Ser83) Antibody
  mouse

 
T8 MTMPTEGTPPPLSGT
T15 TPPPLSGTPIPVPAY
S31 RHAEPGFSLKRPGGL
S39 LKRPGGLSRSLPPRP
S41 RPGGLSRSLPPRPPA
- gap
S55 AKGCIPVSRLFPPRT
T62 SRLFPPRTPGWHQPQ
S74 QPQPRRVSFLCETSE
S80 VSFLCETSEPLQSPG
S85 ETSEPLQSPGYDPSR
Y88 EPLQSPGYDPSRPES
- gap
S111 LSRLGHGSYGEVFKV
K117 GSYGEVFKVRSKEDG
Y132 RLYAVKRYMsPFRGP
S134-p YAVKRYMsPFRGPKD
K140 MsPFRGPKDRTRKLA
K145 GPKDRTRKLAEVGGH
G151 RKLAEVGGHEKVGQH
K154 AEVGGHEKVGQHPHC
T403 QPPGPPATPPGSPPC
S407 PPATPPGSPPCSPLL
T417 CSPLLDSTLSSSWDN
S432 DSIGPSLSPETVLSR
T444 LSRITRRTSTPRGRY
S445 SRITRRTSTPRGRYI
T446 RITRRTSTPRGRYIP
- gap
- gap
T460 PRDALDLTDVDSEPP
S464 LDLTDVDSEPPRGPC
- gap
T473 PPRGPCPTFEPRNLL
S486 LLSLFEDSLDPA___
  starfish

 
S8 MQSDFESSLRENGFR
S16 LRENGFRSPRPLPKF
S31 LQEQVTFSQKKHRGT
T39 QKKHRGTTPRRTGPP
T43 RGTTPRRTGPPRPPL
- gap
S57 LKSVPPVSRLFPNKT
T64 SRLFPNKTREEESRP
S75-p ESRPRAVsFRQSEPS
S82 sFRQSEPSVLQSPHY
S86 SEPSVLQSPHYNEKS
Y89 SVLQSPHYNEKSTES
- gap
S112 VQKLGEGSFGEVYKV
K118 GSFGEVYKVKCKEDD
S133 KFYAVKRSRERFKGE
E135 YAVKRSRERFKGEAD
A141 RERFKGEADRKRKLE
K146 GEADRKRKLEEVHQH
Q152 RKLEEVHQHETLSRH
T155 EEVHQHETLSRHPNC
T419 PLTGISATPTTKCFD
- gap
- gap
S462 PASYPVISTSGTPLL
- under review  
- gap
- gap
S483 TPLHQPRSSSPICHG
- gap
S508 PNGSPNISAVHDDPA
- gap
- gap
- gap
T545 LMQIFEDTDDN____
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