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Protein Page:
ABCG2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCG2 Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. Monomer or homodimer; disulfide-linked. Up-regulated in brain tumors. Highly expressed in placenta. Low expression in small intestine, liver and colon. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, iron; Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: mitochondrial membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; protein homodimerization activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity; heme transporter activity; xenobiotic-transporting ATPase activity; ATP binding
Biological Process: ATP catabolic process; response to drug; heme transport; urate metabolic process; transport; cellular iron ion homeostasis; multidrug transport; xenobiotic transport; transmembrane transport
Reference #:  Q9UNQ0 (UniProtKB)
Alt. Names/Synonyms: ABC transporter; ABC15; ABCG2; ABCP; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2; BCRP; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; EST157481; MGC102821; mitoxantrone resistance protein; Mitoxantrone resistance-associated protein; MRX; MXR; MXR1; placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter
Gene Symbols: ABCG2
Molecular weight: 72,314 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ABCG2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T362‑p
intracellular localization: T362‑p
molecular association, regulation: T362‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2 ______MSSSNVEVF
0 1 S13 VEVFIPVSQGNTNGF
0 1 S50-p CYRVKLKsGFLPCRK
0 1 S100-p LAARKDPsGLsGDVL
0 1 S103-p RKDPsGLsGDVLING
0 1 S143-p VRENLQFsAALRLAT
0 1 Q166 ERINRVIQELGLDKV
0 1 K172 IQELGLDKVADSKVG
0 1 K177 LDKVADSKVGTQFIR
0 3 S187-p TQFIRGVsGGERKRt
0 1 T194-p sGGERKRtsIGMELI
0 2 S195-p GGERKRtsIGMELIT
0 1 S353-p KAELHQLsGGEKKKK
0 1 K358 QLsGGEKKKKItVFK
0 1 I361 GGEKKKKItVFKEIS
1 0 T362-p GEKKKKItVFKEISY
0 1 Y464-p HEYISGYyRVSSYFL
  mouse

 
S2 ______MSSSNDHVL
S13 DHVLVPMSQRNNNGL
S50 TYRVKVKSGFLVRKT
K99 LAARKDPKGLSGDVL
S102 RKDPKGLSGDVLING
S142 VRENLQFSAALRLPT
K165-ub ERINTIIkELGLEkV
K171-ub IkELGLEkVADSkVG
K176-ub LEkVADSkVGTQFIR
S186 TQFIRGISGGERKRT
T193 SGGERKRTSIGMELI
S194 GGERKRTSIGMELIT
P353 KAELDQLPGAQEkKG
K358-ub QLPGAQEkKGTSAFK
- under review  
S362 AQEkKGTSAFKEPVY
Y464 HEYISGYYRVSSYFF
  rat

 
S2-p ______MsSSNDHVL
S13-p DHVLVPMsQRNKNGL
S50 TYRVKVKSGFLVRKT
R99 LAARKDPRGLSGDVL
S102 RKDPRGLSGDVLING
S142 VRENLQFSAALRLPK
K165 ERINTIIKELGLDKV
K171 IKELGLDKVADSKVG
K176 LDKVADSKVGTQFTR
S186 TQFTRGISGGERKRT
T193 SGGERKRTSIGMELI
S194 GGERKRTSIGMELIT
P353 KAELDQLPVAQKKKG
K358 QLPVAQKKKGsSAFR
S361-p VAQKKKGsSAFREPV
S362 AQKKKGsSAFREPVY
Y464 HEYISGYYRVSSYFF
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