Home

ABCG2 (human)

Overview ABCG2 Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. Monomer or homodimer; disulfide-linked. Up-regulated in brain tumors. Highly expressed in placenta. Low expression in small intestine, liver and colon. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Transporter Cellular Component: plasma membrane; integral to membrane Molecular Function: protein binding; protein homodimerization activity; transporter activity; ATPase activity, coupled to transmembrane movement of substances; heme transporter activity; xenobiotic-transporting ATPase activity; ATP binding Biological Process: response to drug; heme transport; urate metabolic process; cellular iron ion homeostasis; transport; multidrug transport; transmembrane transport Reference #:  Q9UNQ0 (UniProtKB) Alt. Names/Synonyms: ABC transporter; ABC15; ABCG2; ABCP; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2; BCRP; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; EST157481; MGC102821; mitoxantrone resistance protein; Mitoxantrone resistance-associated protein; MRX; MXR; MXR1; placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter Gene Symbols: ABCG2 Molecular weight: 72,314 Da Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ABCG2

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: T362‑p intracellular localization: T362‑p molecular association, regulation: T362‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S50-p	CYRVKLKsGFLPCRK
0	1		S100-p	LAARKDPsGLsGDVL
0	1		S103-p	RKDPsGLsGDVLING
0	1		S143-p	VRENLQFsAALRLAT
0	1		Q166	ERINRVIQELGLDKV
0	1		K172	IQELGLDKVADSKVG
0	1		K177	LDKVADSKVGTQFIR
0	3		S187-p	TQFIRGVsGGERKRt
0	1		T194-p	sGGERKRtsIGMELI
0	2		S195-p	GGERKRtsIGMELIT
0	1		-	under review
1	0		T362-p	GEKKKKItVFKEISY

	mouse
S50	TYRVKVKSGFLVRKT
K99	LAARKDPKGLSGDVL
S102	RKDPKGLSGDVLING
S142	VRENLQFSAALRLPT
K165-u	ERINTIIkELGLEkV
K171-u	IkELGLEkVADSkVG
K176-u	LEkVADSkVGTQFIR
S186	TQFIRGISGGERKRT
T193	SGGERKRTSIGMELI
S194	GGERKRTSIGMELIT
K358-u	QLPGAQEkKGTSAFK
S362	AQEkKGTSAFKEPVY

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.