Home

AGR2 (human)

Overview AGR2 Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region Molecular Function: protein binding Reference #:  O95994 (UniProtKB) Alt. Names/Synonyms: AG-2; AG2; AGR2; anterior gradient 2 homolog; anterior gradient homolog 2 (Xenopus laevis); Anterior gradient protein 2 homolog; GOB-4; hAG-2; HPC8; PDIA17; protein disulfide isomerase family A, member 17; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog; XAG-2 Gene Symbols: AGR2 Molecular weight: 19,979 Da Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AGR2 2LNS - A/B=41-175 (human) 2LNT - A=41-175 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2LNS 2LNT  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S36-p	AKKDTKDsRPKLPQT
0	13		Y111-p	FVLLNLVyEttDKHL
0	3		T113-p	LLNLVyEttDKHLSP
0	3		T114-p	LNLVyEttDKHLSPD
0	2		Y124-p	HLSPDGQyVPRIMFV
0	16		K165-a	ALLLDNMkkALKLLK
0	7		K166-a	LLLDNMkkALKLLKT

	mouse
S36	AKKDPKDSRPKLPQT
Y111	FVLLNLVYETTDKHL
T113	LLNLVYETTDKHLSP
T114	LNLVYETTDKHLSPD
Y124	HLSPDGQYVPRIVFV
K165	ALLYDNMKKALKLLK
K166	LLYDNMKKALKLLKT

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.