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Protein Page:
AGR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AGR2 Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region
Molecular Function: protein binding
Reference #:  O95994 (UniProtKB)
Alt. Names/Synonyms: AG-2; AG2; AGR2; anterior gradient 2 homolog; anterior gradient homolog 2 (Xenopus laevis); Anterior gradient protein 2 homolog; GOB-4; hAG-2; HPC8; PDIA17; protein disulfide isomerase family A, member 17; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog; XAG-2
Gene Symbols: AGR2
Molecular weight: 19,979 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AGR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 13 Y111-p FVLLNLVyEttDKHL
0 3 T113-p LLNLVyEttDKHLSP
0 3 T114-p LNLVyEttDKHLSPD
0 2 Y124-p HLSPDGQyVPRIMFV
0 16 K165-a ALLLDNMkkALKLLK
0 7 K166-a LLLDNMkkALKLLKT
  mouse

 
Y111 FVLLNLVYETTDKHL
T113 LLNLVYETTDKHLSP
T114 LNLVYETTDKHLSPD
Y124 HLSPDGQYVPRIVFV
K165 ALLYDNMKKALKLLK
K166 LLYDNMKKALKLLKT
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