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ABCC2 (human)

Overview ABCC2 Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Transporter Cellular Component: intercellular canaliculus; integral to plasma membrane; apical plasma membrane; plasma membrane Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding Biological Process: transport; transmembrane transport; organic anion transport Reference #:  Q92887 (UniProtKB) Alt. Names/Synonyms: ABC30; ABCC2; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; CMRP; DJS; KIAA1010; MRP2; Multidrug resistance-associated protein 2 Gene Symbols: ABCC2 Molecular weight: 174,207 Da Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ABCC2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 237500 601107  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K63-u	TKRSSTTkLYLAKQV
0	1		K236-a	VDEEMKTkTLVSKFE
0	2		K278-u	ARLPGLNkNQSQsQD
0	1		N279	RLPGLNkNQSQsQDA
0	1		S281	PGLNkNQSQsQDALV
0	4		S283-p	LNkNQSQsQDALVLE
0	1		E293	ALVLEDVEkKKKkSG
0	1		K294-u	LVLEDVEkKKKkSGT
0	1		K298-a	DVEkKKKkSGTkKDV
0	1		K302-a	KKKkSGTkKDVPkSW
0	1		K307-a	GTkKDVPkSWLMKAL
0	1		K413-u	TLSNLARkEYTVGET
0	4		K493-a	TIQVKNMkNKDKRLK
0	2		K493-u	TIQVKNMkNKDKRLK
0	1		K500	kNKDKRLKIMNEILS
0	2		K510-u	NEILSGIkILKYFAW
0	1		R522	FAWEPSFRDQVQNLR
0	1		K615-u	VSTERLEkyLGGDDL
0	1		Y616-p	STERLEkyLGGDDLD
0	1		T723-p	KDNILFGtEFNEkRY
0	2		K728-u	FGtEFNEkRYQQVLE
0	1		K797	AVDAHVGKHIFNKVL
0	1		K802	VGKHIFNKVLGPNGL
0	1		K811-u	LGPNGLLkGKTRLLV
0	1		K813	PNGLLkGKTRLLVTH
0	1		K842	GNGTIVEKGSYSALL
0	1		Y845	TIVEKGSYSALLAKk
0	2		K852-a	YSALLAKkGEFAkNL
0	2		K857-a	AKkGEFAkNLKTFLR
0	1		K857	AKkGEFAKNLKTFLR
0	1		K860	GEFAkNLKTFLRHTG
0	12		S878-p	EATVHDGsEEEDDDY
0	1		S890	DDYGLISSVEEIPED
0	5		S900	EIPEDAASITMRREN
0	2		T902	PEDAASITMRRENSF
0	1		R934	LRNSLKTRNVNsLkE
0	1		S938-p	LKTRNVNsLkEDEEL
0	1		K940-u	TRNVNsLkEDEELVk
0	1		K947-u	kEDEELVkGQKLIKK
1	0		K953	VkGQKLIKKEFIETG
0	1		S1153-p	RQLRRLDsVTRSPIY
0	1		R1156	RRLDsVTRSPIYSHF
0	1		K1184-u	EHQQRFLkHNEVRID
0	1		V1188	RFLkHNEVRIDTNQK
0	1		K1277-u	ERITEYTkVENEAPW
0	1		K1297	PPPDWPSKGKIQFNN
0	1		R1318	PELDLVLRGITCDIG
0	1		G1325	RGITCDIGSMEKIGV
0	1		K1329	CDIGSMEKIGVVGRT
0	1		K1340	VGRTGAGKSSLTNCL
0	1		N1400	MNLDPFNNYSDEEIW
0	1		S1501-p	RLHTIMDsDKVMVLD
0	1		K1544-u	IENVNSTkF______

	mouse
K62	TKRFAITKFYLAKQV
K235	IEENLKAKSLTSKFK
K276-u	GTSHGLTkkQsQSQD
K277-u	TSHGLTkkQsQSQDV
S279-p	HGLTkkQsQSQDVLV
S281	LTkkQsQSQDVLVLE
K291-u	VLVLEDSkKKKKKSE
K292	LVLEDSkKKKKKSEA
K296	DSkKKKKKSEATKDF
T300	KKKKSEATKDFPKSW
K305	EATKDFPKSWLVKAL
R411	TLSNLARRQYTIGET
K491-a	KIQVQNMkNKDKRLk
K491-u	KIQVQNMkNKDKRLk
K498-u	kNKDKRLkIMNEILS
K508-u	NEILSGIkILKYFAW
K520-u	FAWEPSFkEQVNSIR
Q613	VSVDRLEQYLGSDDL
Y614	SVDRLEQYLGSDDLD
S721	KDNILFGSEYDEkKY
K726-u	FGSEYDEkKYQRVIE
K795-u	AVDTHVGkHIFNkVV
K800-u	VGkHIFNkVVGPNGL
S809	VGPNGLLSGkTRILV
K811-u	PNGLLSGkTRILVTH
K840-u	GKGTILEkGSySDLM
Y843-p	TILEkGSySDLMDKK
K850	ySDLMDKKGVFAkNW
K855	DKKGVFAKNWkTFMK
K855-u	DKKGVFAkNWkTFMK
K858-u	GVFAkNWkTFMKHSG
S876-p	EATVDNDsEEEDGDC
T888-p	GDCGLIPtVEEIPDD
S898-p	EIPDDAAsLtMRREN
T900-p	PDDAAsLtMRRENSL
K932-u	LKSSLKIkSVNALNK
A936	LKIkSVNALNKKEEV
K939	kSVNALNKKEEVVKG
K945	NKKEEVVKGQKLIKK
K951	VKGQKLIKKEFVETG
S1151	RQLRRLDSVTkSPIY
K1154-u	RRLDSVTkSPIYSHF
A1182	EHQQRFLANSEkQID
K1186-u	RFLANSEkQIDTNQK
N1275	ERINEYINVDNEAPW
K1295-u	PPADWPKkGEIQFNN
K1316-u	PELDLVLkGITCNIk
K1323-u	kGITCNIkSTEkVGV
K1327-u	CNIkSTEkVGVVGRT
K1338-u	VGRTGAGkSSLTNCL
K1398-u	MNLDPFNkYSDEEIW
S1499	RLHTIMDSDKIMVLD
E1542	IESVNHTEL______

	rat
K62	TKRSSITKFYLAKQV
R235	IDEGFKTRSVTSKFE
K276	ATLHGLNKKQSQSQD
K277	TLHGLNKKQSQSQDV
S279	HGLNKKQSQSQDVLV
S281	LNKKQSQSQDVLVLE
K291	VLVLEEAKKKSEKTT
K292	LVLEEAKKKSEKTTK
K296	EAKKKSEKTTKDYPK
T298	KKKSEKTTKDYPKSW
K303	KTTKDYPKSWLIKSL
K409	TLSNLARKQYTIGET
K489	NIQVQNMKNKDKRLK
K489	NIQVQNMKNKDKRLK
K496	KNKDKRLKIMNEILS
K506	NEILSGIKILKYFAW
Q518	FAWEPSFQEQVQGIR
R611	VSVDRLERYLGGDDL
Y612	SVDRLERYLGGDDLD
S719	KDNILFGSEYNEKKY
K724	FGSEYNEKKYQQVLK
K793	AVDAHVGKHIFNKVV
K798	VGKHIFNKVVGPNGL
A807	VGPNGLLAGKTRIFV
K809	PNGLLAGKTRIFVTH
K838	GKGTILEKGSYRDLL
Y841	TILEKGSYRDLLDKK
K848	YRDLLDKKGVFARNW
R853	DKKGVFARNWKTFMK
R853	DKKGVFARNWKTFMK
K856	GVFARNWKTFMKHSG
S874	EATVNNDSEAEDDDD
T886	DDDGLIPTMEEIPED
S896	EIPEDAASLAMRREN
A898	PEDAASLAMRRENSL
K930	LKNSLKIKNVNVLKE
V934	LKIKNVNVLKEKEKE
K936	IKNVNVLKEKEKEVE
E943	KEKEKEVEGQKLIkK
K949-s	VEGQKLIkKEFVETG
S1149	RQLRRLDSVTKSPIY
K1152	RRLDSVTKSPIYSHF
A1180	EHQQRFLAWNEKQID
K1184	RFLAWNEKQIDINQK
N1273	ERISEYINVENEAPW
H1293	PPADWPRHGEIQFNN
K1314	PELDLVLKGITCNIK
K1321	KGITCNIKSGEKVGV
K1325	CNIKSGEKVGVVGRT
K1336	VGRTGAGKSSLTNCL
K1396	MNLDPFNKYSDEEVW
S1497	RLHTIMDSDKIMVLD
E1540	IENVNHTEL______

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