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Protein Page:
CBFB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CBFB CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1. A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. Belongs to the CBF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: osteoblast differentiation; transcription from RNA polymerase II promoter; lymphocyte differentiation; cell maturation; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q13951 (UniProtKB)
Alt. Names/Synonyms: CBF-beta; CBFB; Core-binding factor subunit beta; core-binding factor, beta subunit; PEA2-beta; PEBB; PEBP2-beta; PEBP2B; polyomavirus enhancer binding protein 2, beta subunit; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
Gene Symbols: CBFB
Molecular weight: 21,508 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CBFB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K11-a VVPDQRSkFENEEFF
0 1 T80 WQGEQRQTPSREYVD
0 42 T150-p FEEARRRtREFEDRD
0 18 - gap
0 2 - gap
0 10 K177-a QLLAVTGkKTTRP__
  CBFB iso2  
K11 VVPDQRSKFENEEFF
T80 WQGEQRQTPSREYVD
T150-p FEEARRRtREFEDRD
S173-p ARRQQDPsPGsNLGG
S176-p QQDPsPGsNLGGGDD
- gap
  mouse

 
K11 VVPDQRSKFENEEFF
T80-p WQGEQRQtPSREYVD
T150-p FEEARRRtREFEDRD
S173-p ARRQQDPsPGsNLGG
S176-p QQDPsPGsNLGGGDD
- gap
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