Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CPLX1 (human)

Overview
CPLX1 Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: cell soma; dendrite; synapse; cytosol
Molecular Function: syntaxin-1 binding; neurotransmitter transporter activity
Biological Process: synaptic transmission; synaptic vesicle exocytosis; exocytosis; glutamate secretion; insulin secretion; neurotransmitter secretion
Reference #:  O14810 (UniProtKB)
Alt. Names/Synonyms: complexin 1; Complexin I; Complexin-1; CPLX1; CPX I; CPX-I; CPX1; synaphin 2; Synaphin-2
Gene Symbols: CPLX1
Molecular weight: 15,030 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPLX1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S90 QAAMEANSEGSLTRP
0 1 S93 MEANSEGSLTRPKKA
2 2 S115-p EVEEEDEsILDTVIK
  mouse

 
S90-p QAAMEANsEGsLTRP
S93-p MEANsEGsLTRPKKA
S115-p EPEEEDEsILDTVIK
  rat

 
S90 QAAMEANSEGSLTRP
S93 MEANSEGSLTRPKKA
S115-p EPEEEDEsILDTVIK
  cow

 
S90 QAALEANSEGSLTRP
S93 LEANSEGSLTRPKKA
S115-p AAEEEDEsILDTVIK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.