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Protein Page:
CPLX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CPLX1 Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cell soma; dendrite; synapse; cytosol
Molecular Function: syntaxin-1 binding; neurotransmitter transporter activity
Biological Process: synaptic transmission; synaptic vesicle exocytosis; exocytosis; glutamate secretion; insulin secretion; neurotransmitter secretion
Reference #:  O14810 (UniProtKB)
Alt. Names/Synonyms: complexin 1; Complexin I; Complexin-1; CPLX1; CPX I; CPX-I; CPX1; synaphin 2; Synaphin-2
Gene Symbols: CPLX1
Molecular weight: 15,030 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPLX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K14-ac QALGGATkDMGKMLG
0 2 S90 QAAMEANSEGSLtRP
0 1 S93 MEANSEGSLtRPKKA
0 1 T95-p ANSEGSLtRPKKAIP
2 2 S115-p EVEEEDEsILDTVIK
  mouse

 
K14 QALGGATKDMGKMLG
S90-p QAAMEANsEGsLTRP
S93-p MEANsEGsLTRPKKA
T95 ANsEGsLTRPKKAIP
S115-p EPEEEDEsILDTVIK
  rat

 
K14-ac QALGGATkDMGKMLG
S90 QAAMEANSEGSLTRP
S93 MEANSEGSLTRPKKA
T95 ANSEGSLTRPKKAIP
S115-p EPEEEDEsILDTVIK
  cow

 
K14 QALGGATKDMGKMLG
S90 QAALEANSEGSLTRP
S93 LEANSEGSLTRPKKA
T95 ANSEGSLTRPKKAIP
S115-p AAEEEDEsILDTVIK
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