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Protein Page:
TYR (human)

Overview
TYR This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 1.14.18.1; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - riboflavin; Oxidoreductase
Cellular Component: lysosome; perinuclear region of cytoplasm; melanosome membrane; cytoplasm; melanosome; integral to membrane; Golgi-associated vesicle
Molecular Function: protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; monophenol monooxygenase activity
Biological Process: cell proliferation; thymus development; visual perception; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process
Reference #:  P14679 (UniProtKB)
Alt. Names/Synonyms: LB24-AB; Monophenol monooxygenase; OCA1A; OCAIA; SHEP3; SK29-AB; Tumor rejection antigen AB; TYR; TYRO; Tyrosinase; tyrosinase (oculocutaneous albinism IA)
Gene Symbols: TYR
Molecular weight: 60,393 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TYR

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S523-p MEKEDYHsLYQsHL_
1 0 S527-p DYHsLYQsHL_____
  mouse

 
S526 MDKDDYHSLLYQSHL
S531 YHSLLYQSHL_____
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