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Protein Page:
TYR (human)

TYR This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Oxidoreductase; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - riboflavin
Chromosomal Location of Human Ortholog: 11q14.3
Cellular Component: lysosome; perinuclear region of cytoplasm; melanosome membrane; cytoplasm; melanosome; integral to membrane; Golgi-associated vesicle; cytosol; nucleus
Molecular Function: protein binding; protein homodimerization activity; copper ion binding; protein heterodimerization activity; monooxygenase activity; monophenol monooxygenase activity
Biological Process: melanin biosynthetic process; cell proliferation; response to cAMP; response to vitamin D; thymus development; visual perception; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process; response to UV
Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ib; Albinism, Oculocutaneous, Type Ia; Skin/hair/eye Pigmentation, Variation In, 3
Reference #:  P14679 (UniProtKB)
Alt. Names/Synonyms: LB24-AB; Monophenol monooxygenase; OCA1A; OCAIA; SHEP3; SK29-AB; Tumor rejection antigen AB; TYR; TYRO; Tyrosinase; tyrosinase (oculocutaneous albinism IA)
Gene Symbols: TYR
Molecular weight: 60,393 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


1 0 S523-p MEKEDYHsLYQsHL_
1 0 S527-p DYHsLYQsHL_____

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