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TYR (human)

Overview TYR This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Oxidoreductase; Amino Acid Metabolism - tyrosine; EC 1.14.18.1; Cofactor and Vitamin Metabolism - riboflavin Cellular Component: lysosome; perinuclear region of cytoplasm; cytoplasm; melanosome membrane; melanosome; integral to membrane; Golgi-associated vesicle Molecular Function: protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; monophenol monooxygenase activity Biological Process: cell proliferation; thymus development; visual perception; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process Reference #:  P14679 (UniProtKB) Alt. Names/Synonyms: LB24-AB; Monophenol monooxygenase; OCA1A; OCAIA; SHEP3; SK29-AB; Tumor rejection antigen AB; TYR; TYRO; Tyrosinase; tyrosinase (oculocutaneous albinism IA) Gene Symbols: TYR Molecular weight: 60,393 Da Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TYR

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 103470 203100 601800 606933 606952  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S523-p	MEKEDYHsLYQsHL_
1	0		S527-p	DYHsLYQsHL_____

	mouse
S526	MDKDDYHSLLYQSHL
S531	YHSLLYQSHL_____

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