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Protein Page:
RAD21 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAD21 Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5B and WAPAL; the interaction is direct. Belongs to the rad21 family. Note: This description may include information from UniProtKB.
Cellular Component: cohesin complex; nucleoplasm; membrane; nucleolus; chromosome; nucleus; cytosol; chromosome, pericentric region
Molecular Function: protein binding
Biological Process: regulation of transcription from RNA polymerase II promoter; mitosis; apoptosis; meiotic recombination; double-strand break repair; mitotic cell cycle; chromosome segregation; DNA recombination
Reference #:  O60216 (UniProtKB)
Alt. Names/Synonyms: Double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; hHR21; HR21; HRAD21; KIAA0078; MCD1; Nuclear matrix protein 1; NXP-1; NXP1; protein involved in DNA double-strand break repair; RAD21; RAD21 homolog (S. pombe); SCC1; SCC1 homolog
Gene Symbols: RAD21
Molecular weight: 71,690 Da
Basal Isoelectric point: 4.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAD21

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p FYAHFVLsKRGPLAK
0 1 S40-p FECNLESsVESIIsP
0 6 S46-p SsVESIIsPKVkMAL
0 1 K50-ub SIIsPKVkMALRtsG
0 2 T55-p KVkMALRtsGHLLLG
0 2 S56-p VkMALRtsGHLLLGV
0 2 Y67-p LLGVVRIyHRKAKYL
0 2 K86-ub NEAFIKIkMAFRPGV
0 1 S134-p IDVAQQFsLNQsRVE
0 3 S138-p QQFsLNQsRVEEItM
0 2 T144-p QsRVEEItMREEVGN
0 9 S153-p REEVGNIsILQENDF
0 7 S175-p REIMREGsAFEDDDM
0 8 Y211-p EKINHLEyEDQykDD
0 4 Y215-p HLEyEDQykDDNFGE
0 1 K216-ub LEyEDQykDDNFGEG
0 1 S249-p FDDPPALsEAGVMLP
0 1 S277-p VSMGGPDsPDsVDPV
0 1 S280-p GGPDsPDsVDPVEPM
0 1 T289-p DPVEPMPtMTDQTTL
0 1 T312-p ALEPIDItVKETKAK
0 1 K330-ub KLIVDSVkELDSkTI
0 1 K335-ub SVkELDSkTIRAQLS
0 3 K358-ub LDLAPPTkKLMMWkE
0 2 K364-ub TkKLMMWkEtGGVEk
0 1 T366-p KLMMWkEtGGVEkLF
0 15 K371-ub kEtGGVEkLFsLPAQ
0 1 S374-p GGVEkLFsLPAQPLW
0 3 K387-ub LWNNRLLkLFTRCLt
0 4 T394-p kLFTRCLtPLVPEDL
0 2 K406-ub EDLRKRRkGGEADNL
0 1 K418-ub DNLDEFLkEFENPEV
0 1 S449-p EPIIEEPsRLQEsVM
0 3 S454-p EPsRLQEsVMEAsRT
0 2 S459-p QEsVMEAsRTNIDEs
0 1 S466-p sRTNIDEsAMPPPPP
0 1 K477-ub PPPPQGVkRKAGQID
0 5 S545-p EEEDEDAsGGDQDQE
0 1 K573 GLQRALAKTGAESIS
0 10 K596-ub NRKQAAAkFYSFLVL
0 1 K605-ub YSFLVLKkQQAIELT
0 1 S618-p LTQEEPYsDIIAtPG
0 4 T623-p PYsDIIAtPGPRFHI
  mouse

 
S9 FYAHFVLSKRGPLAK
S40 FECNLESSVESIISP
S46 SSVESIISPKVKMAL
K50 SIISPKVKMALRTSG
T55 KVKMALRTSGHLLLG
S56 VKMALRTSGHLLLGV
Y67 LLGVVRIYHRKAKYL
K86 NEAFIKIKMAFRPGV
S134 IDVAQQFSLNQSRVE
S138 QQFSLNQSRVEEITM
T144 QSRVEEITMREEVGN
S153-p REEVGNIsILQENDF
S175-p REIMREGsAFEDDDM
Y211 EKMNHLEYEDQYKDD
Y215 HLEYEDQYKDDNFGE
K216 LEYEDQYKDDNFGEG
S249 FDDPPALSEAGVMLP
S277 GSLGGPDSPDSVDPV
S280 GGPDSPDSVDPVEPM
T289 DPVEPMPTMTDQTTL
T312 ALEPIDITVKETKAK
K330 KLIVDSVKELDSKTI
K335 SVKELDSKTIRAQLS
K358-ub LDLAPPTkKLMMWKE
K364 TkKLMMWKETGGVEK
T366 KLMMWKETGGVEKLF
K371 KETGGVEKLFFLPAQ
F374 GGVEKLFFLPAQPLW
K387-ub LWNNRLLkLFTRCLT
T394 kLFTRCLTPLVPEDL
K406-ub EDLRKRRkGGEADNL
K418 DNLDEFLKEFENPEV
S453 EPIIEEPSRLQDSVM
S458 EPSRLQDSVMEASRT
S463 QDSVMEASRTTIEES
S470 SRTTIEESAMPPPPP
K481 PPPPQGVKRKAGQID
S549 EEEDEDASGGDQDQE
K577-ub GLQRALAkTGAESIS
K600 NRKQAAAKFYSFLVL
K609 YSFLVLKKQQAIELT
S622 LTQEEPYSDIIATPG
T627 PYSDIIATPGPRFHI
  rat

 
S9 FYAHFVLSKRGPLAK
S40 FECNLESSVESIISP
S46 SSVESIISPKVKMAL
K50 SIISPKVKMALRTSG
T55 KVKMALRTSGHLLLG
S56 VKMALRTSGHLLLGV
Y67 LLGVVRIYHRKAKYL
K86 NEAFIKIKMAFRPGV
S134 IDVAQQFSLNQSRVE
S138 QQFSLNQSRVEEITM
T144 QSRVEEITMREEVGN
S153 REEVGNISILQENDF
S175-p REIMREGsAFEDDDM
Y211 EKINHLEYEDQYKDD
Y215 HLEYEDQYKDDNFGE
K216 LEYEDQYKDDNFGEG
S249 FDDPPALSETGVMLP
S277 GSLGGPDSPDSVDPV
S280 GGPDSPDSVDPVEPM
T289 DPVEPMPTMTDQTTL
T312 ALEPIDITVKETKAK
K330 KLIVDSVKELDSKTI
K335 SVKELDSKTIRAQLS
K358 LDLAPPTKKLMMWKE
K364 TKKLMMWKETGGVEK
T366 KLMMWKETGGVEKLF
K371 KETGGVEKLFSLPAQ
S374 GGVEKLFSLPAQPLW
K387 LWNNRLLKLFTRCLT
T394 KLFTRCLTPLVPEDL
K406 EDLRKRRKGGEADNL
K418 DNLDEFLKEFENPEV
S453 EPIIEEPSRLQDSVM
S458 EPSRLQDSVMEASRT
S463 QDSVMEASRTNIEES
S470 SRTNIEESAMPPPPP
K481 PPPPQGVKRKAGQVD
S549-p EEEDEDAsGGDQDQE
K577 GLQRALAKTGAESIS
K600 NRKQAAAKFYSFLVL
K609 YSFLVLKKQQAIELT
S622 LTQEEPYSDIIATPG
T627 PYSDIIATPGPRFHI
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