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Protein Page:
p40phox (human)

Overview
p40phox a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Cellular Component: membrane; endosome membrane; cytosol; NADPH oxidase complex
Molecular Function: protein dimerization activity; protein binding; superoxide-generating NADPH oxidase activator activity; phosphatidylinositol 3-phosphate binding
Biological Process: positive regulation of catalytic activity; interaction with host; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; immune response
Reference #:  Q15080 (UniProtKB)
Alt. Names/Synonyms: MGC3810; NCF; NCF-4; NCF4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; p40-phox; p40phox; SH3 and PX domain-containing protein 4; SH3PXD4
Gene Symbols: NCF4
Molecular weight: 39,032 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Select Structure to View Below

p40phox

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
3 0 T154-p LRRLRPRtRKVKSVs
0 2 S161-p tRKVKSVsPQGNSVD
0 33 Y243-p PTNWLRCyYYEDTIS
2 0 S315-p RQARGLPsQKRLFPW
4311 : Phospho-p40phox (Thr154) Antibody
  p40phox iso2  
T154 LRRLRPRTRKVKSVS
S161 TRKVKSVSPQGNSVD
Y243 PTNWLRCYYYEDTIS
- gap
  mouse

 
T154-p LRRLRPRtRKIKGVs
S161-p tRKIKGVsPQGAIMD
Y243-p TTNWLRCyFYEDTGK
S315-p KQARGLPsQKRLFPW
4311 : Phospho-p40phox (Thr154) Antibody
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