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Protein Page:
p40phox (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p40phox a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Cellular Component: membrane; endosome membrane; cytosol; NADPH oxidase complex
Molecular Function: protein dimerization activity; protein binding; superoxide-generating NADPH oxidase activator activity; phosphatidylinositol 3-phosphate binding
Biological Process: positive regulation of catalytic activity; interaction with host; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response
Reference #:  Q15080 (UniProtKB)
Alt. Names/Synonyms: MGC3810; NCF; NCF-4; NCF4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; p40-phox; p40phox; SH3 and PX domain-containing protein 4; SH3PXD4
Gene Symbols: NCF4
Molecular weight: 39,032 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Select Structure to View Below

p40phox

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S11-p AQQLRAEsDFEQLPD
0 1 S23-p LPDDVAIsANIADIE
0 1 T47-p VFVIEVKtKGGsKyL
0 1 S51-p EVKtKGGsKyLIYRR
0 1 Y53-p KtKGGsKyLIYRRYR
0 1 K78 ERFGPDSKSSALACT
0 1 K92 TLPTLPAKVYVGVKQ
3 0 T154-p LRRLRPRtRKVKSVs
0 3 S161-p tRKVKSVsPQGNSVD
0 1 K228-ub LSFVKILkDFPEEDD
0 34 Y243-p PTNWLRCyYyEDTIS
0 1 Y245-p NWLRCyYyEDTISTI
2 0 S315-p RQARGLPsQKRLFPW
4311 : Phospho-p40phox (Thr154) Antibody
  p40phox iso2  
S11 AQQLRAESDFEQLPD
S23 LPDDVAISANIADIE
T47 VFVIEVKTKGGSKYL
S51 EVKTKGGSKYLIYRR
Y53 KTKGGSKYLIYRRYR
K78 ERFGPDSKSSALACT
K92 TLPTLPAKVYVGVKQ
T154 LRRLRPRTRKVKSVS
S161 TRKVKSVSPQGNSVD
K228 LSFVKILKDFPEEDD
Y243 PTNWLRCYYYEDTIS
Y245 NWLRCYYYEDTISTI
- gap
  mouse

 
S11 AQQLRSESDFEQLPD
S23 LPDDVAVSANIADIE
T47 VFVIEVKTKGGSKYL
S51 EVKTKGGSKYLIYRR
Y53 KTKGGSKYLIYRRYR
K78-ac ERFGPESkNSPFTCS
K92-ac SLPTLPAkVYMGAKQ
T154-p LRRLRPRtRKIKGVs
S161-p tRKIKGVsPQGAIMD
K228 GSFVKILKDFPEDED
Y243-p TTNWLRCyFYEDTGK
Y245 NWLRCyFYEDTGKTI
S315-p KQARGLPsQKRLFPW
4311 : Phospho-p40phox (Thr154) Antibody
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