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p40phox (human)

Overview p40phox a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase Cellular Component: membrane; cytosol; NADPH oxidase complex Molecular Function: protein dimerization activity; protein binding; phosphoinositide binding Biological Process: interaction with host; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell communication; immune response Reference #:  Q15080 (UniProtKB) Alt. Names/Synonyms: MGC3810; NCF; NCF-4; NCF4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; p40-phox; p40phox; SH3 and PX domain-containing protein 4; SH3PXD4 Gene Symbols: NCF4 Molecular weight: 39,032 Da Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states

Select Structure to View Below p40phox 1H6H - A=2-144 (human) 1OEY - J/K/L/M=237-339 (human) 1W6X - A/B=174-228 (human) 1W70 - A/B=174-228 (human) 1Z9Q - A=167-233 (human) 2DYB - A=1-339 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S11-p	AQQLRAEsDFEQLPD
0	1		S23-p	LPDDVAIsANIADIE
0	1		K78	ERFGPDSKSSALACT
0	1		K92	TLPTLPAKVYVGVKQ
3	0		T154-p	LRRLRPRtRKVKSVs
0	2		S161-p	tRKVKSVsPQGNSVD
0	1		K228-u	LSFVKILkDFPEEDD
0	33		Y243-p	PTNWLRCyYyEDTIS
0	1		Y245-p	NWLRCyYyEDTISTI
2	0		S315-p	RQARGLPsQKRLFPW

	p40phox iso2
S11	AQQLRAESDFEQLPD
S23	LPDDVAISANIADIE
K78	ERFGPDSKSSALACT
K92	TLPTLPAKVYVGVKQ
T154	LRRLRPRTRKVKSVS
S161	TRKVKSVSPQGNSVD
K228	LSFVKILKDFPEEDD
Y243	PTNWLRCYYYEDTIS
Y245	NWLRCYYYEDTISTI
-	gap

	mouse
S11	AQQLRSESDFEQLPD
S23	LPDDVAVSANIADIE
K78-a	ERFGPESkNSPFTCS
K92-a	SLPTLPAkVYMGAKQ
T154-p	LRRLRPRtRKIKGVs
S161-p	tRKIKGVsPQGAIMD
K228	GSFVKILKDFPEDED
Y243-p	TTNWLRCyFYEDTGK
Y245	NWLRCyFYEDTGKTI
S315-p	KQARGLPsQKRLFPW

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