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Protein Page:
CASP5 (human)

Overview
CASP5 Mediator of programmed cell death (apoptosis). Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Up-regulated by bacterial lipopolysaccharides (LPS). Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.22.-; EC 3.4.22.58
Cellular Component: cytoplasm
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: regulation of apoptosis; substantia nigra development; apoptosis; regulation of inflammatory response; proteolysis
Reference #:  P51878 (UniProtKB)
Alt. Names/Synonyms: CASP-5; CASP5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; Caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE(rel)-III; ICE(rel)III; ICEREL-III; ICH-3; ICH3; MGC141966; Protease ICH-3; Protease TY; TY protease
Gene Symbols: CASP5
Molecular weight: 49,736 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S44-p NNVAGQTsIQTLVPN
0 1 Y74-p KTVKMLEyLGKDVLH
0 1 Y103-p KEEEKKKyyDTKIED
0 1 Y104-p EEEKKKyyDTKIEDK
0 1 S156 IEAGPPESAESTNIL
0 1 Y228-p RLLQGLGytVVDEKN
0 1 T229-p LLQGLGytVVDEKNL
0 1 T237-p VVDEKNLtARDMESV
  CASP5 iso3  
- gap
- gap
- gap
- gap
S14-p IEAGPPEsAESTNIL
Y86 RLLQGLGYTVVDEKN
T87 LLQGLGYTVVDEKNL
T95 VVDEKNLTARDMESV
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