Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Casp5 (human)

Casp5 Mediator of programmed cell death (apoptosis). Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Up-regulated by bacterial lipopolysaccharides (LPS). Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Protease; EC
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: regulation of apoptosis; substantia nigra development; apoptosis; proteolysis
Reference #:  P51878 (UniProtKB)
Alt. Names/Synonyms: CASP-5; CASP5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; Caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE(rel)-III; ICE(rel)III; ICEREL-III; ICH-3; ICH3; MGC141966; Protease ICH-3; Protease TY; TY protease
Gene Symbols: CASP5
Molecular weight: 49,736 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

Modification Sites and Domains  

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.