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Casp5 (human)

Overview Casp5 Mediator of programmed cell death (apoptosis). Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Up-regulated by bacterial lipopolysaccharides (LPS). Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.4.22.-; EC 3.4.22.58; Protease Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity Biological Process: regulation of apoptosis; apoptosis; proteolysis Reference #:  P51878 (UniProtKB) Alt. Names/Synonyms: CASP-5; CASP5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; Caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE(rel)-III; ICE(rel)III; ICEREL-III; ICH-3; ICH3; MGC141966; Protease ICH-3; Protease TY; TY protease Gene Symbols: CASP5 Molecular weight: 49,736 Da Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Casp5

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME 3.4.22.- 3.4.22.58  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y74-p	KTVKMLEyLGKDVLH
0	1		S44-p	NNVAGQTsIQTLVPN
0	1		Y103-p	KEEEKKKyyDTKIED
0	1		Y104-p	EEEKKKyyDTKIEDK
0	1		Y228-p	RLLQGLGytVVDEKN
0	1		T229-p	LLQGLGytVVDEKNL
0	1		T237-p	VVDEKNLtARDMESV

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