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UGT1A1 (human)

Overview UGT1A1 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Expressed in liver. Not expressed in skin or kidney. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - androgen and estrogen; EC 2.4.1.17; Carbohydrate Metabolism - ascorbate and aldarate; Membrane protein, integral; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - pentose and glucuronate interconversions; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - starch and sucrose Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane Molecular Function: enzyme inhibitor activity; enzyme binding; protein homodimerization activity; retinoic acid binding; protein heterodimerization activity; glucuronosyltransferase activity; steroid binding Biological Process: response to drug; steroid metabolic process; estrogen metabolic process; organ regeneration; negative regulation of steroid metabolic process; response to lipopolysaccharide; liver development; response to starvation; bilirubin conjugation; heme catabolic process; xenobiotic metabolic process; negative regulation of catalytic activity; porphyrin metabolic process; digestion; flavone metabolic process; retinoic acid metabolic process; heterocycle metabolic process; drug metabolic process; response to nutrient Reference #:  P22309 (UniProtKB) Alt. Names/Synonyms: bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; Bilirubin-specific UDPGT isozyme 1; GNT1; hUG-BR1; UD11; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glucuronosyltransferase 1A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; UDPGT; UDPGT 1-1; UGT-1A; UGT1; UGT1*1; UGT1-01; UGT1.1; UGT1A; UGT1A1 Gene Symbols: UGT1A1 Molecular weight: 59,591 Da Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below UGT1A1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 143500 191740 218800 237900 606785  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S5-p	___MAVEsQGGRPLV
0	1		T78	GAFYTLKTYPVPFQR
0	1		-	under review
0	1		Y337-p	PQTVLWRyTGTRPSN
0	4		K353	ANNTILVKWLPQNDL
0	1		K437-a	VINDKSYkENIMRLS

	mouse
C5	___MTVVCWSSRLLL
K80-u	GSFYTLRkFPVPFQk
K87-u	kFPVPFQkENVTATL
Y339	PQTVLWRYTGTRPSN
K355-a	AKNTILVkWLPQNDL
K439	VINNKSYKENIMRLS

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