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Protein Page:
UGT1A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UGT1A1 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Expressed in liver. Not expressed in skin or kidney. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Membrane protein, integral; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Lipid Metabolism - androgen and estrogen; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; endoplasmic reticulum
Molecular Function: enzyme inhibitor activity; enzyme binding; protein homodimerization activity; retinoic acid binding; protein heterodimerization activity; glucuronosyltransferase activity; steroid binding
Biological Process: response to drug; steroid metabolic process; estrogen metabolic process; negative regulation of steroid metabolic process; organ regeneration; response to lipopolysaccharide; negative regulation of fatty acid metabolic process; liver development; cellular response to hormone stimulus; response to starvation; negative regulation of transferase activity; bilirubin conjugation; flavonoid biosynthetic process; heme catabolic process; xenobiotic metabolic process; negative regulation of catalytic activity; porphyrin metabolic process; digestion; acute-phase response; flavone metabolic process; retinoic acid metabolic process; heterocycle metabolic process; drug metabolic process; response to nutrient
Disease: Gilbert Syndrome; Crigler-najjar Syndrome, Type I; Bilirubin, Serum Level Of, Quantitative Trait Locus 1; Hyperbilirubinemia, Transient Familial Neonatal; Crigler-najjar Syndrome, Type Ii
Reference #:  P22309 (UniProtKB)
Alt. Names/Synonyms: bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; Bilirubin-specific UDPGT isozyme 1; GNT1; hUG-BR1; UD11; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glucuronosyltransferase 1A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; UDPGT; UDPGT 1-1; UGT-1A; UGT1; UGT1*1; UGT1-01; UGT1.1; UGT1A; UGT1A1
Gene Symbols: UGT1A1
Molecular weight: 59,591 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UGT1A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MAVEsQGGRPLV
0 1 T78 GAFYTLKTYPVPFQR
0 1 R85 TYPVPFQREDVKESF
0 1 K262 LFRSDFVKDYPRPIM
0 1 Y337-p PQTVLWRyTGTRPSN
0 5 K353 ANNTILVKWLPQNDL
0 1 K437-ac VINDKSYkENIMRLS
  mouse

 
C5 ___MTVVCWSSRLLL
K80-ub GSFYTLRkFPVPFQk
K87-ub kFPVPFQkENVTATL
K264-sc LMRSDFVkDYPRPIM
Y339 PQTVLWRYTGTRPSN
K355-ac AKNTILVkWLPQNDL
K439 VINNKSYKENIMRLS
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