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Protein Page:
NUPL2 (human)

Overview
NUPL2 Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleoporin
Cellular Component: nuclear membrane; nucleolus; nuclear pore; nucleus; cytosol
Molecular Function: metal ion binding; nuclear export signal receptor activity
Biological Process: mRNA transport; viral reproduction; hexose transport; cytokine and chemokine mediated signaling pathway; carbohydrate metabolic process; mitotic nuclear envelope disassembly; glucose transport; protein export from nucleus; mitotic cell cycle; transmembrane transport
Reference #:  O15504 (UniProtKB)
Alt. Names/Synonyms: CG1; H_RG271G13.9; hCG1; NLP-1; NLP_1; Nucleoporin hCG1; nucleoporin like 2; nucleoporin-like protein 1; Nucleoporin-like protein 2; NUP42 homolog; NUPL2
Gene Symbols: NUPL2
Molecular weight: 44,872 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Select Structure to View Below

NUPL2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y79-p SRDQEKPyFSsFDSG
0 1 S82-p QEKPyFSsFDSGAST
0 1 S85 PyFSsFDSGASTNRK
0 1 S88 SsFDSGASTNRKEGF
0 1 S104-p LSENPFAsLsPDEQK
0 5 S106-p ENPFAsLsPDEQKDE
0 1 Y138-p GQWMFSVysPVKKKP
0 1 S139-p QWMFSVysPVKKKPN
0 2 S305-p AASFSFKsPAASSFG
0 1 S313-p PAASSFGsPGFSGLP
0 1 S347-p SSVAGFGsPGSHSHT
  mouse

 
P81 SRDQDKPPFGSFDSG
S84 QDKPPFGSFDSGAsT
S87 PPFGSFDSGAsTSRG
S90-p GSFDSGAsTSRGFGS
S104 SSQNPFASPLSDEQK
S107 NPFASPLSDEQKDEK
Y138 GQWMFSVYSPVRKKP
S139 QWMFSVYSPVRKKPN
S305 AASFSFKSPEASSFA
S313 PEASSFASPGFSGFP
S347 SSVVGFGSPSPHSQA
  rat

 
P81 SRGQDKPPFGPFDsG
P84 QDKPPFGPFDsGAST
S87-p PPFGPFDsGASTSRG
S90 GPFDsGASTSRGFGS
S104 SPQNPFASPLsDEQK
S107-p NPFASPLsDEQKDEK
Y138 GQWMFSVYSPVRKKP
S139 QWMFSVYSPVRKKPN
S305 AASFSFKSPEASSFG
S313 PEASSFGSPGFSGFP
S345 SSVAAFGSPSPHSQT
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