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NUPL2 (human)

Overview NUPL2 Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Nucleoporin Cellular Component: nuclear membrane; nuclear pore; cytosol; nucleus Molecular Function: nucleic acid binding; zinc ion binding; nuclear export signal receptor activity Biological Process: mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; hexose transport; carbohydrate metabolic process; glucose transport; protein export from nucleus; transmembrane transport Reference #:  O15504 (UniProtKB) Alt. Names/Synonyms: CG1; H_RG271G13.9; hCG1; NLP-1; NLP_1; Nucleoporin hCG1; nucleoporin like 2; nucleoporin-like protein 1; Nucleoporin-like protein 2; NUP42 homolog; NUPL2 Gene Symbols: NUPL2 Molecular weight: 44,872 Da Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states

Select Structure to View Below NUPL2

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y79-p	SRDQEKPyFSSFDSG
0	1		S85	PyFSSFDSGASTNRK
0	1		S88	SSFDSGASTNRKEGF
0	2		S106-p	ENPFASLsPDEQKDE
0	1		S305-p	AASFSFKsPAASSFG

	mouse
P81	SRDQDKPPFGSFDSG
S87	PPFGSFDSGAsTSRG
S90-p	GSFDSGAsTSRGFGS
S107	NPFASPLSDEQKDEK
S305	AASFSFKSPEASSFA

	rat
P81	SRGQDKPPFGPFDsG
S87-p	PPFGPFDsGASTSRG
S90	GPFDsGASTSRGFGS
S107-p	NPFASPLsDEQKDEK
S305	AASFSFKSPEASSFG

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