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SPFH1 (human)

Overview SPFH1 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Belongs to the band 7/mec-2 family. Forms a heteromeric complex with ERLIN2. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; integral to membrane Molecular Function: protein binding Biological Process: ER-associated protein catabolic process Reference #:  D3DR65 (UniProtKB) Alt. Names/Synonyms: Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9; C10orf69; Endoplasmic reticulum lipid raft-associated protein 1; ER lipid raft associated 1; Erlin-1; ERLIN1; ERLN1; KE04; KEO4; Protein KE04; SPFH domain family, member 1; SPFH domain-containing protein 1; SPFH1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 Gene Symbols: ERLIN1 Molecular weight: 39,171 Da Basal Isoelectric point: 7.67  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SPFH1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T4-p	____MNMtQARVLVA
0	1		K115-u	NYTADYDkTLIFNKI
0	2		K156-u	NLKQALQkDLNLMAP
0	1		K192-u	FELMEAEkTKLLIAA
0	1		T193	ELMEAEkTKLLIAAQ
0	1		Y264-p	KAKADAEyYAAHkYA
0	1		K269-a	AEyYAAHkYATSNKH
0	1		T279-p	TSNKHKLtPEYLELK
0	1		R323	YSDIRTGRESsLPSk
0	2		S326-p	IRTGRESsLPSkEAL
0	1		K330-u	RESsLPSkEALEPSG
0	1		K344-u	GENVIQNkESTG___

	mouse
T2	______MTQARLLVA
K113	NYTADYDKTLIFNKI
K154	NLKQALQKDLNTMAP
K190	FELMEAEKtKLLIAA
T191-p	ELMEAEKtKLLIAAQ
Y262	KAKADAEYYAAHKYA
K267	AEYYAAHKYATSNKH
T277	TSNKHKLTPEYLELK
R321-m1	YSDGRTGrEDSLPPE
S324	GRTGrEDSLPPEEAR
E328	rEDSLPPEEAREPSG
K342	GESPIQNKENAG___

	rat
T4	____MNMTQARLLVA
K115	NYTADYDKTLIFNKI
K156	NLKQALQKDLNTMAP
K192	FELMEAEKTKLLIAA
T193	ELMEAEKTKLLIAAQ
Y264	KAKADAEYYAAHKYA
K269	AEYYAAHKYATSNKH
T279	TSNKHKLTPEYLELK
R323	YSDVRTEREGSLSPE
S326	VRTEREGSLSPEETH
E330	REGSLSPEETHEPSG
K344	GESPIQNKENAG___

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