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Protein Page:
PXN (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PXN a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Adaptor/scaffold; Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: cytoskeleton; focal adhesion; lamellipodium; cytoplasm; leading edge; plasma membrane; cell junction; nucleus
Molecular Function: integrin binding; protein binding; receptor signaling complex scaffold activity; zinc ion binding; metal ion binding; protein complex binding; beta-catenin binding; BH4 domain binding; protein kinase binding; vinculin binding
Biological Process: lamellipodium biogenesis; integrin-mediated signaling pathway; focal adhesion formation; regulation of cell shape; peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; activation of MAPK activity; positive regulation of protein kinase activity; cell-matrix adhesion; cytoskeleton organization and biogenesis; cell motility; cell adhesion
Reference #:  Q8VI36 (UniProtKB)
Alt. Names/Synonyms: AW108311; AW123232; OTTMUSP00000015574; OTTMUSP00000015575; Pax; PAXI; Paxillin; Pxn
Gene Symbols: Pxn
Molecular weight: 64,476 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PXN

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: Y31‑p, Y118‑p
carcinogenesis, induced: Y88‑p
cell adhesion, altered: Y31‑p, Y118‑p, T572‑p
cell adhesion, induced: Y31‑p, Y118‑p
cell differentiation, altered: S83‑p
cell growth, altered: Y88‑p
cell motility, altered: Y31‑p, S83‑p, Y118‑p, S126‑p, S130‑p
cell motility, induced: S250‑p
cytoskeletal reorganization: Y31‑p, S83‑p, Y118‑p, S126‑p, S130‑p, T572‑p
activity, induced: Y31‑p, S83‑p, Y118‑p
intracellular localization: S250‑p
molecular association, regulation: Y31‑p, S83‑p, Y118‑p
phosphorylation: Y31‑p, Y118‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 S19 ESTTSHISKRPVFLs
0 1 S26-p SKRPVFLsEEPPysy
0 12 P29 PVFLsEEPPysyPTG
36 69 Y31-p FLsEEPPysyPTGNH
0 4 S32-p LsEEPPysyPTGNHt
0 11 Y33-p sEEPPysyPTGNHty
0 2 T35 EPPysyPTGNHtyQE
0 6 T39-p syPTGNHtyQEIAVP
2 31 Y40-p yPTGNHtyQEIAVPP
1 0 S74 DQWQPSGSRyAHQQP
0 8 Y76-p WQPSGSRyAHQQPPs
1 0 S83 yAHQQPPSPLPVyss
7 64 S83-p yAHQQPPsPLPVyss
1 0 P84 AHQQPPsPLPVysss
0 13 P84 AHQQPPsPLPVysss
1 0 L85 HQQPPsPLPVysssA
1 613 L85 HQQPPsPLPVysssA
3 1321 Y88-p PPsPLPVysssAKNS
0 6 S89-p PsPLPVysssAKNSS
0 16 S90-p sPLPVysssAKNSSA
0 10 S91-p PLPVysssAKNSSAS
0 2 N94 VysssAKNSSASNTQ
0 3 S95 ysssAKNSSASNTQD
0 3 S96 sssAKNSSASNTQDG
0 3 S98 sAKNSSASNTQDGVG
0 8 G103 SASNTQDGVGSLCSR
0 24 S106 NTQDGVGSLCSRAGE
0 2 C108 QDGVGSLCSRAGEEE
0 19 S109 DGVGSLCSRAGEEEH
0 2 G112 GSLCSRAGEEEHVys
55 2483 Y118-p AGEEEHVysFPNKQk
0 109 S119-p GEEEHVysFPNKQks
0 1 K125-ub ysFPNKQksAEPsPt
6 20 S126-p sFPNKQksAEPsPtV
5 17 S130-p KQksAEPsPtVMsss
0 6 T132-p ksAEPsPtVMsssLG
0 2 S135-p EPsPtVMsssLGsNL
0 5 S136-p PsPtVMsssLGsNLs
0 17 S137-p sPtVMsssLGsNLsE
0 2 S140-p VMsssLGsNLsELDR
0 3 S143-p ssLGsNLsELDRLLL
0 2 P163 QHSPPGFPADEAESs
0 4 S170-p PADEAESsPPLPGAL
0 2 P172 DEAESsPPLPGALsP
8 0 S178-p PPLPGALsPLyGIPE
2 25 Y181-p PGALsPLyGIPENNT
0 2 N186 PLyGIPENNTPLGGK
2 1 N187 LyGIPENNTPLGGKA
0 1 T188 yGIPENNTPLGGKAG
2 1 P189 GIPENNTPLGGKAGP
0 1 V198 GGKAGPLVKEKPKRN
0 1 K199 GKAGPLVKEKPKRNG
0 1 K201 AGPLVKEKPKRNGGR
0 1 K203 PLVKEKPKRNGGRGL
0 1 S216 GLEDVRPSVESLLDE
0 1 S219 DVRPSVESLLDELES
0 2 S226 SLLDELESSVPSPVP
0 2 S227 LLDELESSVPSPVPA
0 4 S230 ELESSVPSPVPAITV
0 2 T236 PSPVPAITVNQGEMS
0 2 N238 PVPAITVNQGEMSsP
1 1 S243 TVNQGEMSsPQRVTs
2 5 S244-p VNQGEMSsPQRVTsS
0 8 T249 MSsPQRVTsSQQQTR
1 20 S250-p SsPQRVTsSQQQTRI
0 7 S251 sPQRVTsSQQQTRIs
0 3 T255 VTsSQQQTRIsAssA
1 24 S258-p SQQQTRIsAssAtRE
0 11 S260-p QQTRIsAssAtRELD
0 14 S261-p QTRIsAssAtRELDE
0 7 T263-p RIsAssAtRELDELM
7 8 S272-p ELDELMAsLSDFKMQ
1 1 S274 DELMAsLSDFKMQGL
0 1 K277 MAsLSDFKMQGLEQR
0 3 - gap
0 5 - gap
0 8 S302 WPPSSRQSsPEGQDE
0 8 S303-p PPSSRQSsPEGQDEG
0 3 T318-p GFMAQGKtGsssPPG
0 1 S320-p MAQGKtGsssPPGGL
0 4 S321-p AQGKtGsssPPGGLs
0 18 S322-p QGKtGsssPPGGLsK
0 1 L327 sssPPGGLsKPGsQL
0 2 S328-p ssPPGGLsKPGsQLD
0 12 S332-p GGLsKPGsQLDsMLG
0 5 S336-p KPGsQLDsMLGsLQs
0 9 S340-p QLDsMLGsLQsDLNK
0 1 S343-p sMLGsLQsDLNKLGV
0 1 K363-ub GVCGACKkPIAGQVV
0 1 T371 PIAGQVVTAMGKTWH
0 1 T376 VVTAMGKTWHPEHFV
0 1 S393 HCQEEIGSRNFFERD
0 1 K407-ub DGQPYCEkDyHSLFS
0 24 Y409-p QPYCEkDyHSLFSPR
0 5 S414 kDyHSLFSPRCYYCN
1 0 T430 PILDKVVTALDRTWH
1 1 T435 VVTALDRTWHPEHFF
0 1 K466-ub DGKAYCRkDyFDMFA
0 6 Y468-p KAYCRkDyFDMFAPK
1 0 S489 AILENYISALNTLWH
1 0 S513 FTPFVNGSFFEHDGQ
0 3 S533-p HYHERRGsLCSGCQk
0 1 S536 ERRGsLCSGCQkPIT
0 2 K540-ub sLCSGCQkPITGRCI
0 1 T543 SGCQkPITGRCITAM
1 1 T572-p LKQLNKGtFKEQNDK
0 1 - gap
2541 : Phospho-Paxillin (Tyr118) Antibody
  PXN iso2  
S19 ESTTSHISKRPVFLS
S26 SKRPVFLSEEPPySy
P29 PVFLSEEPPySyPTG
Y31-p FLSEEPPySyPTGNH
S32 LSEEPPySyPTGNHT
Y33-p SEEPPySyPTGNHTy
T35 EPPySyPTGNHTyQE
T39 SyPTGNHTyQEIAVP
Y40-p yPTGNHTyQEIAVPP
S74 DQWQPSGSRyAHQQP
Y76-p WQPSGSRyAHQQPPs
S83 yAHQQPPSPLPVySS
S83-p yAHQQPPsPLPVySS
P84 AHQQPPsPLPVySSS
P84 AHQQPPsPLPVySSS
L85 HQQPPsPLPVySSSA
L85 HQQPPsPLPVySSSA
Y88-p PPsPLPVySSSAKNS
S89 PsPLPVySSSAKNSS
S90 sPLPVySSSAKNSSA
S91 PLPVySSSAKNSSAS
N94 VySSSAKNSSASNTQ
S95 ySSSAKNSSASNTQD
S96 SSSAKNSSASNTQDG
S98 SAKNSSASNTQDGVG
G103 SASNTQDGVGSLCSR
S106 NTQDGVGSLCSRAGE
C108 QDGVGSLCSRAGEEE
S109 DGVGSLCSRAGEEEH
G112 GSLCSRAGEEEHVyS
Y118-p AGEEEHVySFPNKQK
S119 GEEEHVySFPNKQKs
K125 ySFPNKQKsAEPsPt
S126-p SFPNKQKsAEPsPtV
S130-p KQKsAEPsPtVMsss
T132-p KsAEPsPtVMsssLG
S135-p EPsPtVMsssLGsNL
S136-p PsPtVMsssLGsNLs
S137-p sPtVMsssLGsNLsE
S140-p VMsssLGsNLsELDR
S143-p ssLGsNLsELDRLLL
P163 QHSPPGFPADEAESS
S170 PADEAESSPPLPGAL
P172 DEAESSPPLPGALSP
S178 PPLPGALSPLYGIPE
Y181 PGALSPLYGIPENNT
N186 PLYGIPENNTPLGGK
N187 LYGIPENNTPLGGKA
T188 YGIPENNTPLGGKAG
P189 GIPENNTPLGGKAGP
V198 GGKAGPLVKEKPKRN
K199 GKAGPLVKEKPKRNG
K201 AGPLVKEKPKRNGGR
K203 PLVKEKPKRNGGRGL
S216 GLEDVRPSVESLLDE
S219 DVRPSVESLLDELES
S226 SLLDELESSVPSPVP
S227 LLDELESSVPSPVPA
S230 ELESSVPSPVPAITV
T236 PSPVPAITVNQGEMS
N238 PVPAITVNQGEMSSP
S243 TVNQGEMSSPQRVTS
S244 VNQGEMSSPQRVTSS
T249 MSSPQRVTSSQQQTR
S250 SSPQRVTSSQQQTRI
S251 SPQRVTSSQQQTRIS
T255 VTSSQQQTRISASSA
S258 SQQQTRISASSATRE
S260 QQTRISASSATRELD
S261 QTRISASSATRELDE
T263 RISASSATRELDELM
S272-p ELDELMAsLSDFKFM
S274 DELMAsLSDFKFMAQ
K277 MAsLSDFKFMAQGKt
- gap
- gap
- gap
- gap
T284-p KFMAQGKtGsssPPG
S286-p MAQGKtGsssPPGGL
S287-p AQGKtGsssPPGGLs
S288-p QGKtGsssPPGGLsK
L293 sssPPGGLsKPGsQL
S294-p ssPPGGLsKPGsQLD
S298-p GGLsKPGsQLDsMLG
S302-p KPGsQLDsMLGsLQs
S306-p QLDsMLGsLQsDLNK
S309-p sMLGsLQsDLNKLGV
K329 GVCGACKKPIAGQVV
T337 PIAGQVVTAMGKTWH
T342 VVTAMGKTWHPEHFV
S359 HCQEEIGSRNFFERD
K373 DGQPYCEKDYHSLFS
Y375 QPYCEKDYHSLFSPR
S380 KDYHSLFSPRCYYCN
T396 PILDKVVTALDRTWH
T401 VVTALDRTWHPEHFF
K432 DGKAYCRKDyFDMFA
Y434-p KAYCRKDyFDMFAPK
S455 AILENYISALNTLWH
S479 FTPFVNGSFFEHDGQ
S499 HYHERRGSLCSGCQK
S502 ERRGSLCSGCQKPIT
K506 SLCSGCQKPITGRCI
T509 SGCQKPITGRCITAM
T538 LKQLNKGTFKEQNDK
- gap
  human

► Hide Isoforms
 
S19 ESTTSHISKRPVFLS
S26 SKRPVFLSEEtPysy
T29-p PVFLSEEtPysyPtG
Y31-p FLSEEtPysyPtGNH
S32-p LSEEtPysyPtGNHt
Y33-p SEEtPysyPtGNHty
T35-p EtPysyPtGNHtyQE
T39-p syPtGNHtyQEIAVP
Y40-p yPtGNHtyQEIAVPP
S74 DQWQPSSSRFIHQQP
F76 WQPSSSRFIHQQPQs
S83 FIHQQPQSssPVyGs
S83-p FIHQQPQsssPVyGs
S84 IHQQPQsSsPVyGss
S84-p IHQQPQsssPVyGss
S85 HQQPQssSPVyGssA
S85-p HQQPQsssPVyGssA
Y88-p PQsssPVyGssAKTs
G89 QsssPVyGssAKTsS
S90-p sssPVyGssAKTsSV
S91-p ssPVyGssAKTsSVS
T94 VyGssAKTsSVSNPQ
S95-p yGssAKTsSVSNPQD
S96 GssAKTsSVSNPQDs
S98 sAKTsSVSNPQDsVG
S103-p SVSNPQDsVGsPCsR
S106-p NPQDsVGsPCsRVGE
C108 QDsVGsPCsRVGEEE
S109-p DsVGsPCsRVGEEEH
G112 GsPCsRVGEEEHVys
Y118-p VGEEEHVysFPNKQK
S119-p GEEEHVysFPNKQKs
K125 ysFPNKQKsAEPsPt
S126-p sFPNKQKsAEPsPtV
S130-p KQKsAEPsPtVMsts
T132-p KsAEPsPtVMstsLG
S135-p EPsPtVMstsLGsNL
T136-p PsPtVMstsLGsNLS
S137-p sPtVMstsLGsNLSE
S140-p VMstsLGsNLSELDR
S143 tsLGsNLSELDRLLL
P163 QHNPPGFPADEANSs
S170-p PADEANSsPPLPGAL
P172 DEANSsPPLPGALsP
S178-p PPLPGALsPLyGVPE
Y181-p PGALsPLyGVPEtNS
T186-p PLyGVPEtNSPLGGK
N187 LyGVPEtNSPLGGKA
S188 yGVPEtNSPLGGKAG
P189 GVPEtNSPLGGKAGP
T198 GGKAGPLTKEKPKRN
K199 GKAGPLTKEKPKRNG
K201 AGPLTKEKPKRNGGR
K203 PLTKEKPKRNGGRGL
S216 GLEDVRPSVESLLDE
S219 DVRPSVESLLDELEs
S226-p SLLDELEssVPSPVP
S227-p LLDELEssVPSPVPA
S230 ELEssVPSPVPAItV
T236-p PSPVPAItVNQGEMs
N238 PVPAItVNQGEMssP
S243-p tVNQGEMssPQRVts
S244-p VNQGEMssPQRVtst
T249-p MssPQRVtstQQQtR
S250-p ssPQRVtstQQQtRI
T251-p sPQRVtstQQQtRIs
T255-p VtstQQQtRIsAssA
S258-p tQQQtRIsAssAtRE
S260-p QQtRIsAssAtRELD
S261-p QtRIsAssAtRELDE
T263-p RIsAssAtRELDELM
S272-p ELDELMAsLsDFkIQ
S274-p DELMAsLsDFkIQGL
K277-ub MAsLsDFkIQGLEQR
- gap
- gap
S302-p WPRDGGRssPGGQDE
S303-p PRDGGRssPGGQDEG
T318-p GFMAQGKtGsssPPG
S320-p MAQGKtGsssPPGGP
S321-p AQGKtGsssPPGGPP
S322-p QGKtGsssPPGGPPK
P327 sssPPGGPPKPGsQL
P328 ssPPGGPPKPGsQLD
S332-p GGPPKPGsQLDSMLG
S336 KPGsQLDSMLGsLQS
S340-p QLDSMLGsLQSDLNK
S343 SMLGsLQSDLNKLGV
K363 GVCGACKKPIAGQVV
T371 PIAGQVVTAMGKTWH
T376 VVTAMGKTWHPEHFV
S393 HCQEEIGSRNFFERD
K407 DGQPYCEKDYHNLFs
Y409 QPYCEKDYHNLFsPR
S414-p KDYHNLFsPRCYYCN
T430 PILDKVVTALDRTWH
T435 VVTALDRTWHPEHFF
K466 DGKAYCRKDYFDMFA
Y468 KAYCRKDYFDMFAPK
S489 AILENYISALNTLWH
S513 FTPFVNGSFFEHDGQ
S533-p HYHERRGsLCSGCQK
S536 ERRGsLCSGCQKPIT
K540 sLCSGCQKPITGRCI
T543 SGCQKPITGRCITAM
T572 LKQLNKGTFKEQNDK
- gap
2541 : Phospho-Paxillin (Tyr118) Antibody
  PXN iso2  
S19-p ESTTSHIsKRPVFLS
S26 sKRPVFLSEETPySy
T29 PVFLSEETPySyPTG
Y31-p FLSEETPySyPTGNH
S32 LSEETPySyPTGNHT
Y33-p SEETPySyPTGNHTy
T35 ETPySyPTGNHTyQE
T39 SyPTGNHTyQEIAVP
Y40-p yPTGNHTyQEIAVPP
S74-gl DQWQPSSsRFIHQQP
F76 WQPSSsRFIHQQPQs
S83-gl FIHQQPQsssPVyGs
S83-p FIHQQPQsssPVyGs
S84-gl IHQQPQsssPVyGss
S84-p IHQQPQsssPVyGss
S85-gl HQQPQsssPVyGssA
S85-p HQQPQsssPVyGssA
Y88-p PQsssPVyGssAKTs
G89 QsssPVyGssAKTss
S90-p sssPVyGssAKTssV
S91-p ssPVyGssAKTssVs
T94 VyGssAKTssVsNPQ
S95-p yGssAKTssVsNPQD
S96-p GssAKTssVsNPQDs
S98-p sAKTssVsNPQDsVG
S103-p sVsNPQDsVGsPCsR
S106-p NPQDsVGsPCsRVGE
C108 QDsVGsPCsRVGEEE
S109-p DsVGsPCsRVGEEEH
G112 GsPCsRVGEEEHVys
Y118-p VGEEEHVysFPNKQK
S119-p GEEEHVysFPNKQKs
K125 ysFPNKQKsAEPsPt
S126-p sFPNKQKsAEPsPtV
S130-p KQKsAEPsPtVMSts
T132-p KsAEPsPtVMStsLG
S135 EPsPtVMStsLGSNL
T136-p PsPtVMStsLGSNLs
S137-p sPtVMStsLGSNLsE
S140 VMStsLGSNLsELDR
S143-p tsLGSNLsELDRLLL
P163 QHNPPGFPADEANSs
S170-p PADEANSsPPLPGAL
P172 DEANSsPPLPGALsP
S178-p PPLPGALsPLyGVPE
Y181-p PGALsPLyGVPEtNS
T186-p PLyGVPEtNSPLGGK
N187 LyGVPEtNSPLGGKA
S188 yGVPEtNSPLGGKAG
P189 GVPEtNSPLGGKAGP
T198 GGKAGPLTkEkPkRN
K199-ub GKAGPLTkEkPkRNG
K201-ub AGPLTkEkPkRNGGR
K203-ub PLTkEkPkRNGGRGL
S216 GLEDVRPSVESLLDE
S219 DVRPSVESLLDELES
S226 SLLDELESSVPsPVP
S227 LLDELESSVPsPVPA
S230-p ELESSVPsPVPAItV
T236-p PsPVPAItVNQGEMS
N238 PVPAItVNQGEMSsP
S243 tVNQGEMSsPQRVts
S244-p VNQGEMSsPQRVtst
T249-p MSsPQRVtstQQQtR
S250-p SsPQRVtstQQQtRI
T251-p sPQRVtstQQQtRIs
T255-p VtstQQQtRIsAssA
S258-p tQQQtRIsAssAtRE
S260-p QQtRIsAssAtRELD
S261-p QtRIsAssAtRELDE
T263-p RIsAssAtRELDELM
S272-p ELDELMAsLSDFKFM
S274 DELMAsLSDFKFMAQ
K277 MAsLSDFKFMAQGKt
- gap
- gap
- gap
- gap
T284-p KFMAQGKtGsssPPG
S286-p MAQGKtGsssPPGGP
S287-p AQGKtGsssPPGGPP
S288-p QGKtGsssPPGGPPK
P293 sssPPGGPPKPGsQL
P294 ssPPGGPPKPGsQLD
S298-p GGPPKPGsQLDsMLG
S302-p KPGsQLDsMLGsLQS
S306-p QLDsMLGsLQSDLNK
S309 sMLGsLQSDLNKLGV
K329 GVCGACKKPIAGQVV
T337-p PIAGQVVtAMGKTWH
T342 VVtAMGKTWHPEHFV
S359 HCQEEIGSRNFFERD
K373 DGQPYCEKDyHNLFs
Y375-p QPYCEKDyHNLFsPR
S380-p KDyHNLFsPRCYYCN
T396 PILDKVVTALDRTWH
T401 VVTALDRTWHPEHFF
K432 DGKAYCRKDyFDMFA
Y434-p KAYCRKDyFDMFAPK
S455 AILENYISALNTLWH
S479 FTPFVNGSFFEHDGQ
S499 HYHERRGSLCSGCQk
S502 ERRGSLCSGCQkPIt
K506-ub SLCSGCQkPItGRCI
T509-p SGCQkPItGRCITAM
T538 LKQLNKGTFKEQNDK
- gap
2541 : Phospho-Paxillin (Tyr118) Antibody
  PXN iso3  
S19 ESTTSHISKRPVFLS
S26 SKRPVFLSEETPySy
T29 PVFLSEETPySyPTG
Y31-p FLSEETPySyPTGNH
S32 LSEETPySyPTGNHT
Y33-p SEETPySyPTGNHTy
T35 ETPySyPTGNHTyQE
T39 SyPTGNHTyQEIAVP
Y40-p yPTGNHTyQEIAVPP
S74 DQWQPSSSRFIHQQP
F76 WQPSSSRFIHQQPQS
S83 FIHQQPQSSsPVyGS
S83 FIHQQPQSSsPVyGS
S84 IHQQPQSSsPVyGSS
S84 IHQQPQSSsPVyGSS
S85 HQQPQSSSPVyGSSA
S85-p HQQPQSSsPVyGSSA
Y88-p PQSSsPVyGSSAKTS
G89 QSSsPVyGSSAKTSS
S90 SSsPVyGSSAKTSSV
S91 SsPVyGSSAKTSSVS
T94 VyGSSAKTSSVSNPQ
S95 yGSSAKTSSVSNPQD
S96 GSSAKTSSVSNPQDS
S98 SAKTSSVSNPQDSVG
S103 SVSNPQDSVGSPCSR
S106 NPQDSVGSPCSRVGE
C108 QDSVGSPCSRVGEEE
S109 DSVGSPCSRVGEEEH
G112 GSPCSRVGEEEHVyS
Y118-p VGEEEHVySFPNKQK
S119 GEEEHVySFPNKQKS
K125 ySFPNKQKSAEPSPT
S126 SFPNKQKSAEPSPTV
S130 KQKSAEPSPTVMSTS
T132 KSAEPSPTVMSTSLG
S135 EPSPTVMSTSLGSNL
T136 PSPTVMSTSLGSNLS
S137 SPTVMSTSLGSNLSE
S140 VMSTSLGSNLSELDR
S143 TSLGSNLSELDRLLL
P163 QHNPPGFPADEANSS
S170 PADEANSSPPLPGAL
P172 DEANSSPPLPGALSP
S178 PPLPGALSPLYGVPE
Y181 PGALSPLYGVPETNS
T186 PLYGVPETNSPLGGK
N187 LYGVPETNSPLGGKA
S188 YGVPETNSPLGGKAG
P189 GVPETNSPLGGKAGP
T198 GGKAGPLTKEKPKRN
K199 GKAGPLTKEKPKRNG
K201 AGPLTKEKPKRNGGR
K203 PLTKEKPKRNGGRGL
S216 GLEDVRPSVESLLDE
S219 DVRPSVESLLDELES
S226 SLLDELESSVPSPVP
S227 LLDELESSVPSPVPA
S230 ELESSVPSPVPAITV
T236 PSPVPAITVNQGEMS
N238 PVPAITVNQGEMSSP
S243 TVNQGEMSSPQRVts
S244 VNQGEMSSPQRVtst
T249-p MSSPQRVtstQQQTR
S250-p SSPQRVtstQQQTRI
T251-p SPQRVtstQQQTRIs
T255 VtstQQQTRIsAssA
S258-p tQQQTRIsAssAtRE
S260-p QQTRIsAssAtRELD
S261-p QTRIsAssAtRELDE
T263-p RIsAssAtRELDELM
S272 ELDELMASLSDFKGS
S274 DELMASLSDFKGSWP
K277 MASLSDFKGSWPLEE
T311-p PCAARHRtPsLRsPD
S313-p AARHRtPsLRsPDQP
S316-p HRtPsLRsPDQPPPC
- gap
T332 QFMAQGKTGSSSPPG
S334 MAQGKTGSSSPPGGP
S335 AQGKTGSSSPPGGPP
S336 QGKTGSSSPPGGPPK
P341 SSSPPGGPPKPGSQL
P342 SSPPGGPPKPGSQLD
S346 GGPPKPGSQLDSMLG
S350 KPGSQLDSMLGSLQS
S354 QLDSMLGSLQSDLNK
S357 SMLGSLQSDLNKLGV
K377 GVCGACKKPIAGQVV
T385 PIAGQVVTAMGKTWH
T390 VVTAMGKTWHPEHFV
S407 HCQEEIGSRNFFERD
K421 DGQPYCEKDYHNLFS
Y423 QPYCEKDYHNLFSPR
S428 KDYHNLFSPRCYYCN
T444 PILDKVVTALDRTWH
T449 VVTALDRTWHPEHFF
K480 DGKAYCRKDYFDMFA
Y482 KAYCRKDYFDMFAPK
S503 AILENYISALNTLWH
S527 FTPFVNGSFFEHDGQ
S547 HYHERRGSLCSGCQK
S550 ERRGSLCSGCQKPIT
K554 SLCSGCQKPITGRCI
T557 SGCQKPITGRCITAM
T586 LKQLNKGTFKEQNDK
- gap
2541 : Phospho-Paxillin (Tyr118) Antibody
  PXN iso6  
S26 ESTTSHISKRPVFLS
S33 SKRPVFLSEETPYSY
T36 PVFLSEETPYSYPTG
Y38 FLSEETPYSYPTGNH
S39 LSEETPYSYPTGNHT
Y40 SEETPYSYPTGNHTY
T42 ETPYSYPTGNHTYQE
T46 SYPTGNHTYQEIAVP
Y47 YPTGNHTYQEIAVPP
S81 DQWQPSGSRFIHQQP
F83 WQPSGSRFIHQQPQS
S90 FIHQQPQSSSPVYGS
S90 FIHQQPQSSSPVYGS
S91 IHQQPQSSSPVYGSS
S91 IHQQPQSSSPVYGSS
S92 HQQPQSSSPVYGSSA
S92 HQQPQSSSPVYGSSA
Y95 PQSSSPVYGSSAKTS
G96 QSSSPVYGSSAKTSS
S97 SSSPVYGSSAKTSSV
S98 SSPVYGSSAKTSSVS
T101 VYGSSAKTSSVSNPQ
S102 YGSSAKTSSVSNPQD
S103 GSSAKTSSVSNPQDS
S105 SAKTSSVSNPQDSVG
S110 SVSNPQDSVGSPCSR
S113 NPQDSVGSPCSRVGE
C115 QDSVGSPCSRVGEEE
S116 DSVGSPCSRVGEEEH
G119 GSPCSRVGEEEHVYS
Y125 VGEEEHVYSFPNKQK
S126 GEEEHVYSFPNKQKS
K132 YSFPNKQKSAEPSPT
S133 SFPNKQKSAEPSPTV
S137 KQKSAEPSPTVMSTS
T139 KSAEPSPTVMSTSLG
S142 EPSPTVMSTSLGSNL
T143 PSPTVMSTSLGSNLS
S144 SPTVMSTSLGSNLSE
S147 VMSTSLGSNLSELDR
S150 TSLGSNLSELDRLLL
P170 QHNPPGFPADEANSS
S177 PADEANSSPPLPGAL
P179 DEANSSPPLPGALSP
S185 PPLPGALSPLYGVPE
Y188 PGALSPLYGVPETNS
T193 PLYGVPETNSPLGGK
N194 LYGVPETNSPLGGKA
S195 YGVPETNSPLGGKAG
P196 GVPETNSPLGGKAGP
T205 GGKAGPLTKEKPKRN
K206 GKAGPLTKEKPKRNG
K208 AGPLTKEKPKRNGGR
K210 PLTKEKPKRNGGRGL
S223 GLEDVRPSVESLLDE
S226 DVRPSVESLLDELES
S233 SLLDELESSVPSPVP
S234 LLDELESSVPSPVPA
S237 ELESSVPSPVPAITV
T243 PSPVPAITVNQGEMS
N245 PVPAITVNQGEMSSP
S250 TVNQGEMSSPQRVTS
S251 VNQGEMSSPQRVTST
T256 MSSPQRVTSTQQQTR
S257 SSPQRVTSTQQQTRI
T258 SPQRVTSTQQQTRIS
T262 VTSTQQQTRISASSA
S265 TQQQTRISASSATRE
S267 QQTRISASSATRELD
S268 QTRISASSATRELDE
T270 RISASSATRELDELM
S279 ELDELMASLSDFKTS
S281 DELMASLSDFKTSSS
K284 MASLSDFKTSSSTVA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S616-p ATLSRTPsQEQLIAE
  rat

 
S19 ESTTSHISKRPVFLS
S26 SKRPVFLSEEPPySY
P29 PVFLSEEPPySYPTG
Y31-p FLSEEPPySYPTGNH
S32 LSEEPPySYPTGNHT
Y33 SEEPPySYPTGNHTY
T35 EPPySYPTGNHTYQE
T39 SYPTGNHTYQEIAVP
Y40 YPTGNHTYQEIAVPP
S74 DQWQPSGSRyAHQQP
Y76-p WQPSGSRyAHQQPPs
S83 yAHQQPPSPSPIySS
S83-p yAHQQPPsPSPIySS
P84 AHQQPPsPSPIySSS
P84 AHQQPPsPSPIySSS
S85 HQQPPsPSPIySSST
S85 HQQPPsPSPIySSST
Y88-p PPsPSPIySSSTKNS
S89 PsPSPIySSSTKNSS
S90 sPSPIySSSTKNSSA
S91 PSPIySSSTKNSSAS
N94 IySSSTKNSSASNPQ
S95 ySSSTKNSSASNPQD
S96 SSSTKNSSASNPQDS
S98 STKNSSASNPQDSVG
S103 SASNPQDSVGsLCsR
S106-p NPQDSVGsLCsRAGE
C108 QDSVGsLCsRAGEEE
S109-p DSVGsLCsRAGEEEH
G112 GsLCsRAGEEEHVyS
Y118-p AGEEEHVySFPNKQK
S119 GEEEHVySFPNKQKs
K125 ySFPNKQKsAEPsPT
S126-p SFPNKQKsAEPsPTV
S130-p KQKsAEPsPTVMSss
T132 KsAEPsPTVMSssLG
S135 EPsPTVMSssLGSNL
S136-p PsPTVMSssLGSNLS
S137-p sPTVMSssLGSNLSE
S140 VMSssLGSNLSELDR
S143 ssLGSNLSELDRLLL
S163 QRSPSGFSAGMVSVQ
S199 FQDEAESSPPLPGAL
P201 DEAESSPPLPGALSP
S207 PPLPGALSPLYGVPE
Y210 PGALSPLYGVPESNN
S215 PLYGVPESNNLLGGK
N216 LYGVPESNNLLGGKA
N217 YGVPESNNLLGGKAG
L218 GVPESNNLLGGKAGP
M227 GGKAGPLMKEKPKRN
K228 GKAGPLMKEKPKRNG
K230 AGPLMKEKPKRNGGR
K232 PLMKEKPKRNGGRGL
S245 GLEDVRPSVESLLDE
S248 DVRPSVESLLDELEN
N255 SLLDELENSVPSPVP
S256 LLDELENSVPSPVPA
S259 ELENSVPSPVPAITV
T265 PSPVPAITVNQGEMS
N267 PVPAITVNQGEMSSP
S272 TVNQGEMSSPQRVTS
S273 VNQGEMSSPQRVTSS
T278 MSSPQRVTSSQQQTR
S279 SSPQRVTSSQQQTRI
S280 SPQRVTSSQQQTRIs
T284 VTSSQQQTRIsASSA
S287-p SQQQTRIsASSATRE
S289 QQTRIsASSATRELD
S290 QTRIsASSATRELDE
T292 RIsASSATRELDELM
S301 ELDELMASLSDFKFM
S303 DELMASLSDFKFMAQ
K306 MASLSDFKFMAQGKT
- gap
- gap
- gap
- gap
T313 KFMAQGKTGSSsPPG
S315 MAQGKTGSSsPPGGL
S316 AQGKTGSSsPPGGLS
S317-p QGKTGSSsPPGGLSK
L322 SSsPPGGLSKPGSQL
S323 SsPPGGLSKPGSQLD
S327 GGLSKPGSQLDSMLG
S331 KPGSQLDSMLGSLQs
S335 QLDSMLGSLQsDLNK
S338-p SMLGSLQsDLNKLGV
K358 GVCGACKKPIAGQVV
T366 PIAGQVVTAMGKTWH
T371 VVTAMGKTWHPEHFV
S388 HCQEEIGSRNFFERD
K402 DGQPYCEKDYHSLFS
Y404 QPYCEKDYHSLFSPR
S409 KDYHSLFSPRCYYCN
T425 PILDKVVTALDRTWH
T430 VVTALDRTWHPEHFF
K461 DGKAYCRKDYFDMFA
Y463 KAYCRKDYFDMFAPK
S484 AILENYISALNTLWH
S508 FTPFVNGSFFEHDGQ
S528 HYHERRGSLCSGCQK
S531 ERRGSLCSGCQKPIT
K535 SLCSGCQKPITGRCI
T538 SGCQKPITGRCITAM
T567 LKQLNKGTFKEQNDK
- gap
  chicken

 
S19 ESTTSHISKRPVFLT
T26 SKRPVFLTEEtPySY
T29-p PVFLTEEtPySYPTG
Y31-p FLTEEtPySYPTGNH
S32 LTEEtPySYPTGNHT
Y33 TEEtPySYPTGNHTy
T35 EtPySYPTGNHTyQE
T39 SYPTGNHTyQEIAVP
Y40-p YPTGNHTyQEIAVPP
S74 DQWQPSVSRyGHQQP
Y76-p WQPSVSRyGHQQPQs
S83 yGHQQPQSQsPIyss
S83-p yGHQQPQsQsPIyss
Q84 GHQQPQsQsPIysss
Q84 GHQQPQsQsPIysss
S85 HQQPQsQSPIysssA
S85-p HQQPQsQsPIysssA
Y88-p PQsQsPIysssAKss
S89-p QsQsPIysssAKsss
S90-p sQsPIysssAKsssA
S91-p QsPIysssAKsssAs
S94-p IysssAKsssAsVPR
S95-p ysssAKsssAsVPRD
S96-p sssAKsssAsVPRDG
S98-p sAKsssAsVPRDGLS
G103 sAsVPRDGLSsPsPR
S106-p VPRDGLSsPsPRAsE
S108-p RDGLSsPsPRAsEEE
P109 DGLSsPsPRAsEEEH
S112-p SsPsPRAsEEEHVys
Y118-p AsEEEHVysFPNKQK
S119-p sEEEHVysFPNKQKs
K125 ysFPNKQKsAEPsPT
S126-p sFPNKQKsAEPsPTM
S130-p KQKsAEPsPTMTSTs
T132 KsAEPsPTMTSTsLG
S135 EPsPTMTSTsLGSNL
T136 PsPTMTSTsLGSNLs
S137-p sPTMTSTsLGSNLsE
S140 MTSTsLGSNLsELDR
S143-p TsLGSNLsELDRLLL
S164-p HNPPSGFsADEVSRs
S171-p sADEVSRsPsLPNVT
S173-p DEVSRsPsLPNVTGP
G179 PsLPNVTGPHyVIPE
Y182-p PNVTGPHyVIPEsss
S187-p PHyVIPEssssAGGK
S188-p HyVIPEssssAGGKA
S189-p yVIPEssssAGGKAA
S190-p VIPEssssAGGKAAP
T199-p GGKAAPPtKEKPKRN
K200 GKAAPPtKEKPKRNG
K202 AAPPtKEKPKRNGGR
K204 PPtKEKPKRNGGRGI
S217-p GIEDVRPsVEsLLDE
S220-p DVRPsVEsLLDELEs
S227-p sLLDELEssVPsPVP
S228-p LLDELEssVPsPVPA
S231-p ELEssVPsPVPAITV
T237 PsPVPAITVsQGEVS
S239-p PVPAITVsQGEVSsP
S244 TVsQGEVSsPQRVNA
S245-p VsQGEVSsPQRVNAS
N250 VSsPQRVNASQQQTR
A251 SsPQRVNASQQQTRI
S252 sPQRVNASQQQTRIs
T256 VNASQQQTRIsASsA
S259-p SQQQTRIsASsATRE
S261 QQTRIsASsATRELD
S262-p QTRIsASsATRELDE
T264 RIsASsATRELDELM
S273-p ELDELMAsLsDFKFM
S275-p DELMAsLsDFKFMAQ
K278 MAsLsDFKFMAQGKA
- gap
- gap
- gap
- gap
A285 KFMAQGKAGGSSsPP
S288 AQGKAGGSSsPPSTt
S289 QGKAGGSSsPPSTtP
S290-p GKAGGSSsPPSTtPK
T295-p SSsPPSTtPKPGSQL
P296 SsPPSTtPKPGSQLD
S300 STtPKPGSQLDTMLG
T304 KPGSQLDTMLGsLQS
S308-p QLDTMLGsLQSDLNK
S311 TMLGsLQSDLNKLGV
K331 GVCGACKKPIAGQVV
T339 PIAGQVVTAMGKtWH
T344-p VVTAMGKtWHPEHFV
S361-p HCQEEIGsRNFFERD
K375 DGQPYCEKDyHNLFs
Y377-p QPYCEKDyHNLFsPR
S382-p KDyHNLFsPRCYYCN
T398-p PILDKVVtALDRtWH
T403-p VVtALDRtWHPEHFF
K434 DGKAYCRKDyFDMFA
Y436-p KAYCRKDyFDMFAPK
S457-p AILENYIsALNTLWH
S481-p FTPFINGsFFEHDGQ
S501-p HYHERRGsLCsGCQK
S504-p ERRGsLCsGCQKPIT
K508 sLCsGCQKPITGRCI
T511 sGCQKPITGRCITAM
T540-p LKQLNKGtFKEQNDK
- gap
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