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PXN iso2 (human)

Overview PXN iso2 a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Cytoskeletal protein; Cell adhesion Cellular Component: microtubule associated complex; focal adhesion; lamellipodium; plasma membrane; cell cortex Molecular Function: protein binding; zinc ion binding; beta-catenin binding; BH4 domain binding; vinculin binding Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; focal adhesion formation; lamellipodium biogenesis; peptidyl-tyrosine phosphorylation; activation of MAPK activity; signal complex assembly; cytoskeleton organization and biogenesis; signal transduction; branching morphogenesis of a tube; muscle contraction; cell adhesion; cell motility Reference #:  P49023-2 (UniProtKB) Alt. Names/Synonyms: FLJ16691; PAXI; Paxillin; PXN Gene Symbols: PXN Molecular weight: 60,967 Da Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PXN iso2 1KKY - A=142-157 (human) 1KL0 - B=142-157 (human) 2O9V - B=45-54 (human) 2VZD - D/C=1-20 (human) 2VZG - A=141-160 (human) 2VZI - A=312-315 (human) 3GM1 - F/D/C/E=262-274 (human) 3PY7 - A=1-10 (human) 3U3C - A=871-1005 (human) 3U3F - A/D/C/B=871-1005 (human) 4EDN - F/A/J/E/B/H/C/D/I/G=235-364 (human) 2L6F - A=262-275 (chicken) 2L6G - A=140-161 (chicken) 2L6H - A=262-275 (chicken)

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	Sites Implicated In
apoptosis, altered: Y118‑p carcinogenesis, altered: S83‑p, S126‑p, S130‑p cell adhesion, altered: S178‑p, S272‑p cell cycle regulation: Y31‑p, S83‑p, Y118‑p, S126‑p, S130‑p cell growth, altered: Y88‑p cell motility, altered: Y31‑p, Y88‑p, Y118‑p, S272‑p cytoskeletal reorganization: Y31‑p, Y118‑p, S178‑p, S272‑p signaling pathway regulation: Y88‑p transcription, altered: Y31‑p, S83‑p, Y118‑p, S126‑p, S130‑p activation: Y31‑p, Y118‑p intracellular localization: S178‑p, S272‑p molecular association, regulation: Y31‑p, Y118‑p, S272‑p phosphorylation: Y31‑p, Y88‑p, Y118‑p protein degradation: Y31‑p, Y118‑p protein stabilization: S178‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S19	ESTTSHISKRPVFLS
0	1		S26	SKRPVFLSEEtPysy
0	12		T29-p	PVFLSEEtPysyPtG
36	71		Y31-p	FLSEEtPysyPtGNH
0	4		S32-p	LSEEtPysyPtGNHt
0	12		Y33-p	SEEtPysyPtGNHty
0	2		T35-p	EtPysyPtGNHtyQE
0	6		T39-p	syPtGNHtyQEIAVP
2	33		Y40-p	yPtGNHtyQEIAVPP
1	0		S74	DQWQPSSSRFIHQQP
0	11		F76	WQPSSSRFIHQQPQs
1	0		S83	FIHQQPQSssPVyGs
7	55		S83-p	FIHQQPQsssPVyGs
1	0		S84	IHQQPQsSsPVyGsS
0	8		S84-p	IHQQPQsssPVyGsS
1	0		S85	HQQPQssSPVyGsSA
1	615		S85-p	HQQPQsssPVyGsSA
3	1390		Y88-p	PQsssPVyGsSAKTs
0	5		G89	QsssPVyGsSAKTsS
0	18		S90-p	sssPVyGsSAKTsSV
0	9		S91	ssPVyGsSAKTsSVS
0	2		T94	VyGsSAKTsSVSNPQ
0	3		S95-p	yGsSAKTsSVSNPQD
0	3		S96	GsSAKTsSVSNPQDs
0	3		S98	SAKTsSVSNPQDsVG
0	7		S103-p	SVSNPQDsVGsPCsR
0	21		S106-p	NPQDsVGsPCsRVGE
0	2		C108	QDsVGsPCsRVGEEE
0	18		S109-p	DsVGsPCsRVGEEEH
0	2		G112	GsPCsRVGEEEHVys
53	2553		Y118-p	VGEEEHVysFPNKQK
0	122		S119-p	GEEEHVysFPNKQKs
0	1		K125	ysFPNKQKsAEPsPT
5	15		S126-p	sFPNKQKsAEPsPTV
4	13		S130-p	KQKsAEPsPTVMSTs
0	4		T132	KsAEPsPTVMSTsLG
0	1		S135	EPsPTVMSTsLGSNL
0	3		T136	PsPTVMSTsLGSNLS
0	13		S137-p	sPTVMSTsLGSNLSE
0	1		S140	VMSTsLGSNLSELDR
0	3		S143	TsLGSNLSELDRLLL
0	2		P163	QHNPPGFPADEANSS
0	4		S170	PADEANSSPPLPGAL
0	2		P172	DEANSSPPLPGALsP
7	0		S178-p	PPLPGALsPLyGVPE
2	25		Y181-p	PGALsPLyGVPETNS
0	2		T186	PLyGVPETNSPLGGK
2	1		N187	LyGVPETNSPLGGKA
0	1		S188	yGVPETNSPLGGKAG
2	1		P189	GVPETNSPLGGKAGP
0	1		T198	GGKAGPLTKEKPKRN
0	1		K199	GKAGPLTKEKPKRNG
0	1		K201	AGPLTKEKPKRNGGR
0	1		K203	PLTKEKPKRNGGRGL
0	1		S216	GLEDVRPSVESLLDE
0	1		S219	DVRPSVESLLDELES
0	2		S226	SLLDELESSVPSPVP
0	2		S227	LLDELESSVPSPVPA
0	4		S230	ELESSVPSPVPAITV
0	2		T236	PSPVPAITVNQGEMs
0	2		N238	PVPAITVNQGEMssP
1	1		S243-p	TVNQGEMssPQRVts
2	5		S244-p	VNQGEMssPQRVtst
0	8		T249-p	MssPQRVtstQQQtR
1	20		S250-p	ssPQRVtstQQQtRI
0	7		T251-p	sPQRVtstQQQtRIs
0	3		T255-p	VtstQQQtRIsAssA
1	22		S258-p	tQQQtRIsAssAtRE
0	11		S260-p	QQtRIsAssAtRELD
0	14		S261-p	QtRIsAssAtRELDE
0	7		T263-p	RIsAssAtRELDELM
7	4		S272-p	ELDELMAsLsDFkIQ
1	1		S274-p	DELMAsLsDFkIQGL
0	1		K277-u	MAsLsDFkIQGLEQR
0	3		-	gap
0	4		-	gap
0	7		S302-p	WPRDGGRssPGGQDE
0	6		S303-p	PRDGGRssPGGQDEG
0	3		T318	GFMAQGKTGSSSPPG
0	3		S321	AQGKTGSSSPPGGPP
0	14		S322	QGKTGSSSPPGGPPK
0	1		P327	SSSPPGGPPKPGSQL
0	1		P328	SSPPGGPPKPGSQLD
0	8		S332	GGPPKPGSQLDSMLG
0	4		S336	KPGSQLDSMLGSLQS
0	8		S340	QLDSMLGSLQSDLNK
0	1		S343	SMLGSLQSDLNKLGV
0	1		K363	GVCGACKKPIAGQVV
0	1		T371	PIAGQVVTAMGKTWH
0	1		T376	VVTAMGKTWHPEHFV
0	1		S393	HCQEEIGSRNFFERD
0	1		K407	DGQPYCEKDYHNLFs
0	23		Y409	QPYCEKDYHNLFsPR
0	3		S414-p	KDYHNLFsPRCYYCN
1	0		T430	PILDKVVTALDRTWH
1	1		T435	VVTALDRTWHPEHFF
0	1		K466	DGKAYCRKDYFDMFA
0	6		Y468	KAYCRKDYFDMFAPK
1	0		S489	AILENYISALNTLWH
1	0		S513	FTPFVNGSFFEHDGQ
0	3		S533-p	HYHERRGsLCSGCQk
0	1		S536	ERRGsLCSGCQkPIT
0	2		K540-u	sLCSGCQkPITGRCI
0	1		T543	SGCQkPITGRCITAM
1	1		T572	LKQLNKGTFKEQNDK
0	1		-	gap

	PXN iso2
S19-p	ESTTSHIsKRPVFLS
S26	sKRPVFLSEETPySy
T29	PVFLSEETPySyPTG
Y31-p	FLSEETPySyPTGNH
S32	LSEETPySyPTGNHT
Y33-p	SEETPySyPTGNHTy
T35	ETPySyPTGNHTyQE
T39	SyPTGNHTyQEIAVP
Y40-p	yPTGNHTyQEIAVPP
S74-g	DQWQPSSsRFIHQQP
F76	WQPSSsRFIHQQPQs
S83-g	FIHQQPQsssPVyGs
S83-p	FIHQQPQsssPVyGs
S84-g	IHQQPQsssPVyGss
S84-p	IHQQPQsssPVyGss
S85-g	HQQPQsssPVyGssA
S85-p	HQQPQsssPVyGssA
Y88-p	PQsssPVyGssAKTs
G89	QsssPVyGssAKTss
S90-p	sssPVyGssAKTssV
S91-p	ssPVyGssAKTssVs
T94	VyGssAKTssVsNPQ
S95-p	yGssAKTssVsNPQD
S96-p	GssAKTssVsNPQDs
S98-p	sAKTssVsNPQDsVG
S103-p	sVsNPQDsVGsPCsR
S106-p	NPQDsVGsPCsRVGE
C108	QDsVGsPCsRVGEEE
S109-p	DsVGsPCsRVGEEEH
G112	GsPCsRVGEEEHVys
Y118-p	VGEEEHVysFPNKQK
S119-p	GEEEHVysFPNKQKs
K125	ysFPNKQKsAEPsPt
S126-p	sFPNKQKsAEPsPtV
S130-p	KQKsAEPsPtVMSts
T132-p	KsAEPsPtVMStsLG
S135	EPsPtVMStsLGSNL
T136-p	PsPtVMStsLGSNLs
S137-p	sPtVMStsLGSNLsE
S140	VMStsLGSNLsELDR
S143-p	tsLGSNLsELDRLLL
P163	QHNPPGFPADEANSs
S170-p	PADEANSsPPLPGAL
P172	DEANSsPPLPGALsP
S178-p	PPLPGALsPLyGVPE
Y181-p	PGALsPLyGVPEtNS
T186-p	PLyGVPEtNSPLGGK
N187	LyGVPEtNSPLGGKA
S188	yGVPEtNSPLGGKAG
P189	GVPEtNSPLGGKAGP
T198	GGKAGPLTkEkPkRN
K199-u	GKAGPLTkEkPkRNG
K201-u	AGPLTkEkPkRNGGR
K203-u	PLTkEkPkRNGGRGL
S216	GLEDVRPSVESLLDE
S219	DVRPSVESLLDELES
S226	SLLDELESSVPsPVP
S227	LLDELESSVPsPVPA
S230-p	ELESSVPsPVPAItV
T236-p	PsPVPAItVNQGEMS
N238	PVPAItVNQGEMSsP
S243	tVNQGEMSsPQRVts
S244-p	VNQGEMSsPQRVtst
T249-p	MSsPQRVtstQQQtR
S250-p	SsPQRVtstQQQtRI
T251-p	sPQRVtstQQQtRIs
T255-p	VtstQQQtRIsAssA
S258-p	tQQQtRIsAssAtRE
S260-p	QQtRIsAssAtRELD
S261-p	QtRIsAssAtRELDE
T263-p	RIsAssAtRELDELM
S272-p	ELDELMAsLSDFKFM
S274	DELMAsLSDFKFMAQ
K277	MAsLSDFKFMAQGKt
-	gap
-	gap
-	gap
-	gap
T284-p	KFMAQGKtGSssPPG
S287-p	AQGKtGSssPPGGPP
S288-p	QGKtGSssPPGGPPK
P293	SssPPGGPPKPGsQL
P294	ssPPGGPPKPGsQLD
S298-p	GGPPKPGsQLDsMLG
S302-p	KPGsQLDsMLGsLQS
S306-p	QLDsMLGsLQSDLNK
S309	sMLGsLQSDLNKLGV
K329	GVCGACKKPIAGQVV
T337-p	PIAGQVVtAMGKTWH
T342	VVtAMGKTWHPEHFV
S359	HCQEEIGSRNFFERD
K373	DGQPYCEKDyHNLFs
Y375-p	QPYCEKDyHNLFsPR
S380-p	KDyHNLFsPRCYYCN
T396	PILDKVVTALDRTWH
T401	VVTALDRTWHPEHFF
K432	DGKAYCRKDyFDMFA
Y434-p	KAYCRKDyFDMFAPK
S455	AILENYISALNTLWH
S479	FTPFVNGSFFEHDGQ
S499	HYHERRGSLCSGCQk
S502	ERRGSLCSGCQkPIt
K506-u	SLCSGCQkPItGRCI
T509-p	SGCQkPItGRCITAM
T538	LKQLNKGTFKEQNDK
-	gap

	PXN iso3
S19	ESTTSHISKRPVFLS
S26	SKRPVFLSEETPySy
T29	PVFLSEETPySyPTG
Y31-p	FLSEETPySyPTGNH
S32	LSEETPySyPTGNHT
Y33-p	SEETPySyPTGNHTy
T35	ETPySyPTGNHTyQE
T39	SyPTGNHTyQEIAVP
Y40-p	yPTGNHTyQEIAVPP
S74	DQWQPSSSRFIHQQP
F76	WQPSSSRFIHQQPQS
S83	FIHQQPQSssPVyGS
S83	FIHQQPQSssPVyGS
S84	IHQQPQSSsPVyGSS
S84-p	IHQQPQSssPVyGSS
S85	HQQPQSsSPVyGSSA
S85-p	HQQPQSssPVyGSSA
Y88-p	PQSssPVyGSSAKTS
G89	QSssPVyGSSAKTSS
S90	SssPVyGSSAKTSSV
S91	ssPVyGSSAKTSSVS
T94	VyGSSAKTSSVSNPQ
S95	yGSSAKTSSVSNPQD
S96	GSSAKTSSVSNPQDS
S98	SAKTSSVSNPQDSVG
S103	SVSNPQDSVGSPCSR
S106	NPQDSVGSPCSRVGE
C108	QDSVGSPCSRVGEEE
S109	DSVGSPCSRVGEEEH
G112	GSPCSRVGEEEHVys
Y118-p	VGEEEHVysFPNKQK
S119-p	GEEEHVysFPNKQKS
K125	ysFPNKQKSAEPSPT
S126	sFPNKQKSAEPSPTV
S130	KQKSAEPSPTVMSTS
T132	KSAEPSPTVMSTSLG
S135	EPSPTVMSTSLGSNL
T136	PSPTVMSTSLGSNLS
S137	SPTVMSTSLGSNLSE
S140	VMSTSLGSNLSELDR
S143	TSLGSNLSELDRLLL
P163	QHNPPGFPADEANSS
S170	PADEANSSPPLPGAL
P172	DEANSSPPLPGALSP
S178	PPLPGALSPLYGVPE
Y181	PGALSPLYGVPETNS
T186	PLYGVPETNSPLGGK
N187	LYGVPETNSPLGGKA
S188	YGVPETNSPLGGKAG
P189	GVPETNSPLGGKAGP
T198	GGKAGPLTKEKPKRN
K199	GKAGPLTKEKPKRNG
K201	AGPLTKEKPKRNGGR
K203	PLTKEKPKRNGGRGL
S216	GLEDVRPSVESLLDE
S219	DVRPSVESLLDELES
S226	SLLDELESSVPSPVP
S227	LLDELESSVPSPVPA
S230	ELESSVPSPVPAITV
T236	PSPVPAITVNQGEMS
N238	PVPAITVNQGEMSSP
S243	TVNQGEMSSPQRVts
S244	VNQGEMSSPQRVtst
T249-p	MSSPQRVtstQQQTR
S250-p	SSPQRVtstQQQTRI
T251-p	SPQRVtstQQQTRIs
T255	VtstQQQTRIsAssA
S258-p	tQQQTRIsAssAtRE
S260-p	QQTRIsAssAtRELD
S261-p	QTRIsAssAtRELDE
T263-p	RIsAssAtRELDELM
S272	ELDELMASLSDFKGS
S274	DELMASLSDFKGSWP
K277	MASLSDFKGSWPLEE
T311-p	PCAARHRtPsLRsPD
S313-p	AARHRtPsLRsPDQP
S316-p	HRtPsLRsPDQPPPC
-	gap
T332	QFMAQGKTGSSSPPG
S335	AQGKTGSSSPPGGPP
S336	QGKTGSSSPPGGPPK
P341	SSSPPGGPPKPGSQL
P342	SSPPGGPPKPGSQLD
S346	GGPPKPGSQLDSMLG
S350	KPGSQLDSMLGSLQS
S354	QLDSMLGSLQSDLNK
S357	SMLGSLQSDLNKLGV
K377	GVCGACKKPIAGQVV
T385	PIAGQVVTAMGKTWH
T390	VVTAMGKTWHPEHFV
S407	HCQEEIGSRNFFERD
K421	DGQPYCEKDYHNLFS
Y423	QPYCEKDYHNLFSPR
S428	KDYHNLFSPRCYYCN
T444	PILDKVVTALDRTWH
T449	VVTALDRTWHPEHFF
K480	DGKAYCRKDYFDMFA
Y482	KAYCRKDYFDMFAPK
S503	AILENYISALNTLWH
S527	FTPFVNGSFFEHDGQ
S547	HYHERRGSLCSGCQK
S550	ERRGSLCSGCQKPIT
K554	SLCSGCQKPITGRCI
T557	SGCQKPITGRCITAM
T586	LKQLNKGTFKEQNDK
-	gap

	PXN iso6
S26	ESTTSHISKRPVFLS
S33	SKRPVFLSEETPYSY
T36	PVFLSEETPYSYPTG
Y38	FLSEETPYSYPTGNH
S39	LSEETPYSYPTGNHT
Y40	SEETPYSYPTGNHTY
T42	ETPYSYPTGNHTYQE
T46	SYPTGNHTYQEIAVP
Y47	YPTGNHTYQEIAVPP
S81	DQWQPSGSRFIHQQP
F83	WQPSGSRFIHQQPQS
S90	FIHQQPQSSSPVYGS
S90	FIHQQPQSSSPVYGS
S91	IHQQPQSSSPVYGSS
S91	IHQQPQSSSPVYGSS
S92	HQQPQSSSPVYGSSA
S92	HQQPQSSSPVYGSSA
Y95	PQSSSPVYGSSAKTS
G96	QSSSPVYGSSAKTSS
S97	SSSPVYGSSAKTSSV
S98	SSPVYGSSAKTSSVS
T101	VYGSSAKTSSVSNPQ
S102	YGSSAKTSSVSNPQD
S103	GSSAKTSSVSNPQDS
S105	SAKTSSVSNPQDSVG
S110	SVSNPQDSVGSPCSR
S113	NPQDSVGSPCSRVGE
C115	QDSVGSPCSRVGEEE
S116	DSVGSPCSRVGEEEH
G119	GSPCSRVGEEEHVYS
Y125	VGEEEHVYSFPNKQK
S126	GEEEHVYSFPNKQKS
K132	YSFPNKQKSAEPSPT
S133	SFPNKQKSAEPSPTV
S137	KQKSAEPSPTVMSTS
T139	KSAEPSPTVMSTSLG
S142	EPSPTVMSTSLGSNL
T143	PSPTVMSTSLGSNLS
S144	SPTVMSTSLGSNLSE
S147	VMSTSLGSNLSELDR
S150	TSLGSNLSELDRLLL
P170	QHNPPGFPADEANSS
S177	PADEANSSPPLPGAL
P179	DEANSSPPLPGALSP
S185	PPLPGALSPLYGVPE
Y188	PGALSPLYGVPETNS
T193	PLYGVPETNSPLGGK
N194	LYGVPETNSPLGGKA
S195	YGVPETNSPLGGKAG
P196	GVPETNSPLGGKAGP
T205	GGKAGPLTKEKPKRN
K206	GKAGPLTKEKPKRNG
K208	AGPLTKEKPKRNGGR
K210	PLTKEKPKRNGGRGL
S223	GLEDVRPSVESLLDE
S226	DVRPSVESLLDELES
S233	SLLDELESSVPSPVP
S234	LLDELESSVPSPVPA
S237	ELESSVPSPVPAITV
T243	PSPVPAITVNQGEMS
N245	PVPAITVNQGEMSSP
S250	TVNQGEMSSPQRVTS
S251	VNQGEMSSPQRVTST
T256	MSSPQRVTSTQQQTR
S257	SSPQRVTSTQQQTRI
T258	SPQRVTSTQQQTRIS
T262	VTSTQQQTRISASSA
S265	TQQQTRISASSATRE
S267	QQTRISASSATRELD
S268	QTRISASSATRELDE
T270	RISASSATRELDELM
S279	ELDELMASLSDFKTS
S281	DELMASLSDFKTSSS
K284	MASLSDFKTSSSTVA
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S616-p	ATLSRTPsQEQLIAE

	mouse ► Hide Isoforms
S19	ESTTSHISKRPVFLs
S26-p	SKRPVFLsEEPPysy
P29	PVFLsEEPPysyPTG
Y31-p	FLsEEPPysyPTGNH
S32-p	LsEEPPysyPTGNHt
Y33-p	sEEPPysyPTGNHty
T35	EPPysyPTGNHtyQE
T39-p	syPTGNHtyQEIAVP
Y40-p	yPTGNHtyQEIAVPP
S74	DQWQPSGSRyAHQQP
Y76-p	WQPSGSRyAHQQPPs
S83	yAHQQPPSPLPVyss
S83-p	yAHQQPPsPLPVyss
P84	AHQQPPsPLPVysss
P84	AHQQPPsPLPVysss
L85	HQQPPsPLPVysssA
L85	HQQPPsPLPVysssA
Y88-p	PPsPLPVysssAKNS
S89-p	PsPLPVysssAKNSS
S90-p	sPLPVysssAKNSSA
S91-p	PLPVysssAKNSSAS
N94	VysssAKNSSASNTQ
S95	ysssAKNSSASNTQD
S96	sssAKNSSASNTQDG
S98	sAKNSSASNTQDGVG
G103	SASNTQDGVGSLCSR
S106	NTQDGVGSLCSRAGE
C108	QDGVGSLCSRAGEEE
S109	DGVGSLCSRAGEEEH
G112	GSLCSRAGEEEHVys
Y118-p	AGEEEHVysFPNKQk
S119-p	GEEEHVysFPNKQks
K125-u	ysFPNKQksAEPsPt
S126-p	sFPNKQksAEPsPtV
S130-p	KQksAEPsPtVMsss
T132-p	ksAEPsPtVMsssLG
S135-p	EPsPtVMsssLGsNL
S136-p	PsPtVMsssLGsNLs
S137-p	sPtVMsssLGsNLsE
S140-p	VMsssLGsNLsELDR
S143-p	ssLGsNLsELDRLLL
P163	QHSPPGFPADEAESs
S170-p	PADEAESsPPLPGAL
P172	DEAESsPPLPGALsP
S178-p	PPLPGALsPLyGIPE
Y181-p	PGALsPLyGIPENNT
N186	PLyGIPENNTPLGGK
N187	LyGIPENNTPLGGKA
T188	yGIPENNTPLGGKAG
P189	GIPENNTPLGGKAGP
V198	GGKAGPLVKEKPKRN
K199	GKAGPLVKEKPKRNG
K201	AGPLVKEKPKRNGGR
K203	PLVKEKPKRNGGRGL
S216	GLEDVRPSVESLLDE
S219	DVRPSVESLLDELES
S226	SLLDELESSVPSPVP
S227	LLDELESSVPSPVPA
S230	ELESSVPSPVPAITV
T236	PSPVPAITVNQGEMS
N238	PVPAITVNQGEMSsP
S243	TVNQGEMSsPQRVTs
S244-p	VNQGEMSsPQRVTsS
T249	MSsPQRVTsSQQQTR
S250-p	SsPQRVTsSQQQTRI
S251	sPQRVTsSQQQTRIs
T255	VTsSQQQTRIsAssA
S258-p	SQQQTRIsAssAtRE
S260-p	QQTRIsAssAtRELD
S261-p	QTRIsAssAtRELDE
T263-p	RIsAssAtRELDELM
S272-p	ELDELMAsLSDFKMQ
S274	DELMAsLSDFKMQGL
K277	MAsLSDFKMQGLEQR
-	gap
-	gap
S302	WPPSSRQSsPEGQDE
S303-p	PPSSRQSsPEGQDEG
T318-p	GFMAQGKtGSssPPG
S321-p	AQGKtGSssPPGGLs
S322-p	QGKtGSssPPGGLsK
L327	SssPPGGLsKPGsQL
S328-p	ssPPGGLsKPGsQLD
S332-p	GGLsKPGsQLDsMLG
S336-p	KPGsQLDsMLGsLQs
S340-p	QLDsMLGsLQsDLNK
S343-p	sMLGsLQsDLNKLGV
K363-u	GVCGACKkPIAGQVV
T371	PIAGQVVTAMGKTWH
T376	VVTAMGKTWHPEHFV
S393	HCQEEIGSRNFFERD
K407-u	DGQPYCEkDyHSLFS
Y409-p	QPYCEkDyHSLFSPR
S414	kDyHSLFSPRCYYCN
T430	PILDKVVTALDRTWH
T435	VVTALDRTWHPEHFF
K466-u	DGKAYCRkDyFDMFA
Y468-p	KAYCRkDyFDMFAPK
S489	AILENYISALNTLWH
S513	FTPFVNGSFFEHDGQ
S533-p	HYHERRGsLCSGCQk
S536	ERRGsLCSGCQkPIT
K540-u	sLCSGCQkPITGRCI
T543	SGCQkPITGRCITAM
T572-p	LKQLNKGtFKEQNDK
-	gap

	PXN iso2
S19	ESTTSHISKRPVFLS
S26	SKRPVFLSEEPPySy
P29	PVFLSEEPPySyPTG
Y31-p	FLSEEPPySyPTGNH
S32	LSEEPPySyPTGNHT
Y33-p	SEEPPySyPTGNHTy
T35	EPPySyPTGNHTyQE
T39	SyPTGNHTyQEIAVP
Y40-p	yPTGNHTyQEIAVPP
S74	DQWQPSGSRyAHQQP
Y76-p	WQPSGSRyAHQQPPs
S83	yAHQQPPSPLPVySS
S83-p	yAHQQPPsPLPVySS
P84	AHQQPPsPLPVySSS
P84	AHQQPPsPLPVySSS
L85	HQQPPsPLPVySSSA
L85	HQQPPsPLPVySSSA
Y88-p	PPsPLPVySSSAKNS
S89	PsPLPVySSSAKNSS
S90	sPLPVySSSAKNSSA
S91	PLPVySSSAKNSSAS
N94	VySSSAKNSSASNTQ
S95	ySSSAKNSSASNTQD
S96	SSSAKNSSASNTQDG
S98	SAKNSSASNTQDGVG
G103	SASNTQDGVGSLCSR
S106	NTQDGVGSLCSRAGE
C108	QDGVGSLCSRAGEEE
S109	DGVGSLCSRAGEEEH
G112	GSLCSRAGEEEHVyS
Y118-p	AGEEEHVySFPNKQK
S119	GEEEHVySFPNKQKs
K125	ySFPNKQKsAEPsPt
S126-p	SFPNKQKsAEPsPtV
S130-p	KQKsAEPsPtVMsss
T132-p	KsAEPsPtVMsssLG
S135-p	EPsPtVMsssLGsNL
S136-p	PsPtVMsssLGsNLs
S137-p	sPtVMsssLGsNLsE
S140-p	VMsssLGsNLsELDR
S143-p	ssLGsNLsELDRLLL
P163	QHSPPGFPADEAESS
S170	PADEAESSPPLPGAL
P172	DEAESSPPLPGALSP
S178	PPLPGALSPLYGIPE
Y181	PGALSPLYGIPENNT
N186	PLYGIPENNTPLGGK
N187	LYGIPENNTPLGGKA
T188	YGIPENNTPLGGKAG
P189	GIPENNTPLGGKAGP
V198	GGKAGPLVKEKPKRN
K199	GKAGPLVKEKPKRNG
K201	AGPLVKEKPKRNGGR
K203	PLVKEKPKRNGGRGL
S216	GLEDVRPSVESLLDE
S219	DVRPSVESLLDELES
S226	SLLDELESSVPSPVP
S227	LLDELESSVPSPVPA
S230	ELESSVPSPVPAITV
T236	PSPVPAITVNQGEMS
N238	PVPAITVNQGEMSSP
S243	TVNQGEMSSPQRVTS
S244	VNQGEMSSPQRVTSS
T249	MSSPQRVTSSQQQTR
S250	SSPQRVTSSQQQTRI
S251	SPQRVTSSQQQTRIS
T255	VTSSQQQTRISASSA
S258	SQQQTRISASSATRE
S260	QQTRISASSATRELD
S261	QTRISASSATRELDE
T263	RISASSATRELDELM
S272-p	ELDELMAsLSDFKFM
S274	DELMAsLSDFKFMAQ
K277	MAsLSDFKFMAQGKt
-	gap
-	gap
-	gap
-	gap
T284-p	KFMAQGKtGSssPPG
S287-p	AQGKtGSssPPGGLs
S288-p	QGKtGSssPPGGLsK
L293	SssPPGGLsKPGsQL
S294-p	ssPPGGLsKPGsQLD
S298-p	GGLsKPGsQLDsMLG
S302-p	KPGsQLDsMLGsLQs
S306-p	QLDsMLGsLQsDLNK
S309-p	sMLGsLQsDLNKLGV
K329	GVCGACKKPIAGQVV
T337	PIAGQVVTAMGKTWH
T342	VVTAMGKTWHPEHFV
S359	HCQEEIGSRNFFERD
K373	DGQPYCEKDYHSLFS
Y375	QPYCEKDYHSLFSPR
S380	KDYHSLFSPRCYYCN
T396	PILDKVVTALDRTWH
T401	VVTALDRTWHPEHFF
K432	DGKAYCRKDyFDMFA
Y434-p	KAYCRKDyFDMFAPK
S455	AILENYISALNTLWH
S479	FTPFVNGSFFEHDGQ
S499	HYHERRGSLCSGCQK
S502	ERRGSLCSGCQKPIT
K506	SLCSGCQKPITGRCI
T509	SGCQKPITGRCITAM
T538	LKQLNKGTFKEQNDK
-	gap

	rat
S19	ESTTSHISKRPVFLS
S26	SKRPVFLSEEPPySY
P29	PVFLSEEPPySYPTG
Y31-p	FLSEEPPySYPTGNH
S32	LSEEPPySYPTGNHT
Y33	SEEPPySYPTGNHTY
T35	EPPySYPTGNHTYQE
T39	SYPTGNHTYQEIAVP
Y40	YPTGNHTYQEIAVPP
S74	DQWQPSGSRyAHQQP
Y76-p	WQPSGSRyAHQQPPs
S83	yAHQQPPSPSPIySS
S83-p	yAHQQPPsPSPIySS
P84	AHQQPPsPSPIySSS
P84	AHQQPPsPSPIySSS
S85	HQQPPsPSPIySSST
S85	HQQPPsPSPIySSST
Y88-p	PPsPSPIySSSTKNS
S89	PsPSPIySSSTKNSS
S90	sPSPIySSSTKNSSA
S91	PSPIySSSTKNSSAS
N94	IySSSTKNSSASNPQ
S95	ySSSTKNSSASNPQD
S96	SSSTKNSSASNPQDS
S98	STKNSSASNPQDSVG
S103	SASNPQDSVGsLCsR
S106-p	NPQDSVGsLCsRAGE
C108	QDSVGsLCsRAGEEE
S109-p	DSVGsLCsRAGEEEH
G112	GsLCsRAGEEEHVyS
Y118-p	AGEEEHVySFPNKQK
S119	GEEEHVySFPNKQKs
K125	ySFPNKQKsAEPsPT
S126-p	SFPNKQKsAEPsPTV
S130-p	KQKsAEPsPTVMSss
T132	KsAEPsPTVMSssLG
S135	EPsPTVMSssLGSNL
S136-p	PsPTVMSssLGSNLS
S137-p	sPTVMSssLGSNLSE
S140	VMSssLGSNLSELDR
S143	ssLGSNLSELDRLLL
S163	QRSPSGFSAGMVSVQ
S199	FQDEAESSPPLPGAL
P201	DEAESSPPLPGALSP
S207	PPLPGALSPLYGVPE
Y210	PGALSPLYGVPESNN
S215	PLYGVPESNNLLGGK
N216	LYGVPESNNLLGGKA
N217	YGVPESNNLLGGKAG
L218	GVPESNNLLGGKAGP
M227	GGKAGPLMKEKPKRN
K228	GKAGPLMKEKPKRNG
K230	AGPLMKEKPKRNGGR
K232	PLMKEKPKRNGGRGL
S245	GLEDVRPSVESLLDE
S248	DVRPSVESLLDELEN
N255	SLLDELENSVPSPVP
S256	LLDELENSVPSPVPA
S259	ELENSVPSPVPAITV
T265	PSPVPAITVNQGEMS
N267	PVPAITVNQGEMSSP
S272	TVNQGEMSSPQRVTS
S273	VNQGEMSSPQRVTSS
T278	MSSPQRVTSSQQQTR
S279	SSPQRVTSSQQQTRI
S280	SPQRVTSSQQQTRIs
T284	VTSSQQQTRIsASSA
S287-p	SQQQTRIsASSATRE
S289	QQTRIsASSATRELD
S290	QTRIsASSATRELDE
T292	RIsASSATRELDELM
S301	ELDELMASLSDFKFM
S303	DELMASLSDFKFMAQ
K306	MASLSDFKFMAQGKT
-	gap
-	gap
-	gap
-	gap
T313	KFMAQGKTGSSsPPG
S316	AQGKTGSSsPPGGLS
S317-p	QGKTGSSsPPGGLSK
L322	SSsPPGGLSKPGSQL
S323	SsPPGGLSKPGSQLD
S327	GGLSKPGSQLDSMLG
S331	KPGSQLDSMLGSLQs
S335	QLDSMLGSLQsDLNK
S338-p	SMLGSLQsDLNKLGV
K358	GVCGACKKPIAGQVV
T366	PIAGQVVTAMGKTWH
T371	VVTAMGKTWHPEHFV
S388	HCQEEIGSRNFFERD
K402	DGQPYCEKDYHSLFS
Y404	QPYCEKDYHSLFSPR
S409	KDYHSLFSPRCYYCN
T425	PILDKVVTALDRTWH
T430	VVTALDRTWHPEHFF
K461	DGKAYCRKDYFDMFA
Y463	KAYCRKDYFDMFAPK
S484	AILENYISALNTLWH
S508	FTPFVNGSFFEHDGQ
S528	HYHERRGSLCSGCQK
S531	ERRGSLCSGCQKPIT
K535	SLCSGCQKPITGRCI
T538	SGCQKPITGRCITAM
T567	LKQLNKGTFKEQNDK
-	gap

	chicken
S19	ESTTSHISKRPVFLT
T26	SKRPVFLTEEtPySY
T29-p	PVFLTEEtPySYPTG
Y31-p	FLTEEtPySYPTGNH
S32	LTEEtPySYPTGNHT
Y33	TEEtPySYPTGNHTy
T35	EtPySYPTGNHTyQE
T39	SYPTGNHTyQEIAVP
Y40-p	YPTGNHTyQEIAVPP
S74	DQWQPSVSRyGHQQP
Y76-p	WQPSVSRyGHQQPQs
S83	yGHQQPQSQsPIyss
S83-p	yGHQQPQsQsPIyss
Q84	GHQQPQsQsPIysss
Q84	GHQQPQsQsPIysss
S85	HQQPQsQSPIysssA
S85-p	HQQPQsQsPIysssA
Y88-p	PQsQsPIysssAKss
S89-p	QsQsPIysssAKsss
S90-p	sQsPIysssAKsssA
S91-p	QsPIysssAKsssAs
S94-p	IysssAKsssAsVPR
S95-p	ysssAKsssAsVPRD
S96-p	sssAKsssAsVPRDG
S98-p	sAKsssAsVPRDGLS
G103	sAsVPRDGLSsPsPR
S106-p	VPRDGLSsPsPRAsE
S108-p	RDGLSsPsPRAsEEE
P109	DGLSsPsPRAsEEEH
S112-p	SsPsPRAsEEEHVys
Y118-p	AsEEEHVysFPNKQK
S119-p	sEEEHVysFPNKQKs
K125	ysFPNKQKsAEPsPT
S126-p	sFPNKQKsAEPsPTM
S130-p	KQKsAEPsPTMTSTs
T132	KsAEPsPTMTSTsLG
S135	EPsPTMTSTsLGSNL
T136	PsPTMTSTsLGSNLs
S137-p	sPTMTSTsLGSNLsE
S140	MTSTsLGSNLsELDR
S143-p	TsLGSNLsELDRLLL
S164-p	HNPPSGFsADEVSRs
S171-p	sADEVSRsPsLPNVT
S173-p	DEVSRsPsLPNVTGP
G179	PsLPNVTGPHyVIPE
Y182-p	PNVTGPHyVIPEsss
S187-p	PHyVIPEssssAGGK
S188-p	HyVIPEssssAGGKA
S189-p	yVIPEssssAGGKAA
S190-p	VIPEssssAGGKAAP
T199-p	GGKAAPPtKEKPKRN
K200	GKAAPPtKEKPKRNG
K202	AAPPtKEKPKRNGGR
K204	PPtKEKPKRNGGRGI
S217-p	GIEDVRPsVEsLLDE
S220-p	DVRPsVEsLLDELEs
S227-p	sLLDELEssVPsPVP
S228-p	LLDELEssVPsPVPA
S231-p	ELEssVPsPVPAITV
T237	PsPVPAITVsQGEVS
S239-p	PVPAITVsQGEVSsP
S244	TVsQGEVSsPQRVNA
S245-p	VsQGEVSsPQRVNAS
N250	VSsPQRVNASQQQTR
A251	SsPQRVNASQQQTRI
S252	sPQRVNASQQQTRIs
T256	VNASQQQTRIsASsA
S259-p	SQQQTRIsASsATRE
S261	QQTRIsASsATRELD
S262-p	QTRIsASsATRELDE
T264	RIsASsATRELDELM
S273-p	ELDELMAsLsDFKFM
S275-p	DELMAsLsDFKFMAQ
K278	MAsLsDFKFMAQGKA
-	gap
-	gap
-	gap
-	gap
A285	KFMAQGKAGGSSsPP
S289	QGKAGGSSsPPSTtP
S290-p	GKAGGSSsPPSTtPK
T295-p	SSsPPSTtPKPGSQL
P296	SsPPSTtPKPGSQLD
S300	STtPKPGSQLDTMLG
T304	KPGSQLDTMLGsLQS
S308-p	QLDTMLGsLQSDLNK
S311	TMLGsLQSDLNKLGV
K331	GVCGACKKPIAGQVV
T339	PIAGQVVTAMGKtWH
T344-p	VVTAMGKtWHPEHFV
S361-p	HCQEEIGsRNFFERD
K375	DGQPYCEKDyHNLFs
Y377-p	QPYCEKDyHNLFsPR
S382-p	KDyHNLFsPRCYYCN
T398-p	PILDKVVtALDRtWH
T403-p	VVtALDRtWHPEHFF
K434	DGKAYCRKDyFDMFA
Y436-p	KAYCRKDyFDMFAPK
S457-p	AILENYIsALNTLWH
S481-p	FTPFINGsFFEHDGQ
S501-p	HYHERRGsLCsGCQK
S504-p	ERRGsLCsGCQKPIT
K508	sLCsGCQKPITGRCI
T511	sGCQKPITGRCITAM
T540-p	LKQLNKGtFKEQNDK
-	gap

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