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Protein Page:
FOXO3A (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; Autophagy
Cellular Component: membrane; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; tissue development; transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; initiation of primordial ovarian follicle growth; apoptosis; antral ovarian follicle growth; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; ovulation from ovarian follicle; pattern specification process; oocyte maturation; regulation of cell proliferation; regulation of translation; regulation of transcription from RNA polymerase II promoter; embryonic development; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9WVH4 (UniProtKB)
Alt. Names/Synonyms: 1110048B16Rik; 2010203A17Rik; C76856; Fkhr2; FKHRL1; forkhead box O3; Forkhead box O3a; Forkhead protein FKHR2; Foxo3; Foxo3a; OTTMUSP00000022929; OTTMUSP00000022930
Gene Symbols: Foxo3
Molecular weight: 71,064 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXO3A

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: T32‑p
apoptosis, inhibited: T32‑p
cell cycle regulation: T32‑p
cell growth, altered: T32‑p
cytoskeletal reorganization: T32‑p
transcription, inhibited: T32‑p
intracellular localization: T32‑p, S314‑p, S317‑p, S320‑p
molecular association, regulation: T32‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 29 S7-p _MAEAPAsPVPLsPL
1 24 S12-p PAsPVPLsPLEVELD
0 1 S26 DPEFEPQSRPRSCtW
0 4 S30 EPQSRPRSCtWPLQR
57 94 T32-p QSRPRSCtWPLQRPE
0 3 S43-p QRPELQAsPAKPsGE
0 1 S48-p QAsPAKPsGETAADs
0 1 S55-p sGETAADsMIPEEDD
1 0 S89-p GVSSTLGsGLLLEDS
0 1 S160 RNAWGNLSYADLITR
0 1 Y161 NAWGNLSYADLITRA
2 0 T178 SSPDKRLTLSQIYEW
0 8 Y183 RLTLSQIYEWMVRCV
4 0 S208-p SSAGWKNsIRHNLSL
1 1 S214 NsIRHNLSLHSRFMR
1 0 S230 QNEGTGKSSWWIINP
1 0 S231 NEGTGKSSWWIINPD
2 0 K241-ac IINPDGGkSGKAPRR
1 0 S242 INPDGGkSGKAPRRR
20 79 S252-p APRRRAVsMDNSNkY
2 0 K258-ac VsMDNSNkYTKSRGR
1 0 K270-ac RGRAAKKkAALQAAP
0 10 S279-p ALQAAPEsADDsPsQ
1 17 S283-p APEsADDsPsQLSkW
0 3 S285-p EsADDsPsQLSkWPG
0 2 S288 DDsPsQLSkWPGsPt
2 0 K289-ac DsPsQLSkWPGsPtS
4 68 S293-p QLSkWPGsPtSRssD
0 1 T295-p SkWPGsPtSRssDEL
0 2 S296 kWPGsPtSRssDELD
0 5 S298-p PGsPtSRssDELDAW
1 2 S299-p GsPtSRssDELDAWT
0 1 T306 sDELDAWTDFRSRTN
0 2 S310 DAWTDFRSRTNsNAs
3 1 S314-p DFRSRTNsNAsTVsG
7 1 S317-p SRTNsNAsTVsGRLS
0 1 T318 RTNsNAsTVsGRLSP
7 0 S320-p NsNAsTVsGRLSPIL
2 1 S343 QDDDGPLSPMLYSSS
0 1 A394 DDLLDNIALPPSQPS
2 0 S398 DNIALPPSQPSPPGG
4 4 S412-p GLMQRGSsFPYTAKs
0 1 S419-p sFPYTAKssGLGsPt
0 4 S420-p FPYTAKssGLGsPtG
4 4 S424-p AKssGLGsPtGsFNS
1 3 T426-p ssGLGsPtGsFNStV
0 1 S428-p GLGsPtGsFNStVFG
0 1 T432-p PtGsFNStVFGPSSL
0 1 S438 StVFGPSSLNSLRQS
0 2 S550 LGGSRALSNSVSNMG
2 0 S554 RALSNSVSNMGLSDS
2 0 K568-ac SSSLGSAkHQQQsPA
2 0 S573-p SAkHQQQsPASQSMQ
2 0 S587 QTLSDSLSGSSLYSA
3 0 S625 SLECDMESIIRSELM
2 0 S643 GLDFNFDSLISTQNV
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
  human

 
S7-p _MAEAPAsPAPLsPL
S12-p PAsPAPLsPLEVELD
S26-p DPEFEPQsRPRsCtW
S30-p EPQsRPRsCtWPLQR
T32-p QsRPRsCtWPLQRPE
S43-p QRPELQAsPAKPSGE
S48 QAsPAKPSGETAADS
S55 SGETAADSMIPEEED
S90 GGSGTLGSGLLLEDS
S161-p RNAWGNLsyADLITR
Y162-p NAWGNLsyADLITRA
T179-p SSPDKRLtLSQIyEW
Y184-p RLtLSQIyEWMVRCV
S209-p SSAGWKNsIRHNLsL
S215-p NsIRHNLsLHSRFMR
S231-p QNEGTGKssWWIINP
S232-p NEGTGKssWWIINPD
K242-ac IINPDGGksGKAPRR
S243-p INPDGGksGKAPRRR
S253-p APRRRAVsMDNSNkY
K259-ac VsMDNSNkYTKSRGR
K271 RGRAAKKKAALQTAP
S280-p ALQTAPEsADDsPsQ
S284-p APEsADDsPsQLskW
S286-p EsADDsPsQLskWPG
S289-p DDsPsQLskWPGsPt
K290-ac DsPsQLskWPGsPts
S294-p QLskWPGsPtsRsSD
T296-p skWPGsPtsRsSDEL
S297-p kWPGsPtsRsSDELD
S299-p PGsPtsRsSDELDAW
S300 GsPtsRsSDELDAWt
T307-p SDELDAWtDFRsRTN
S311-p DAWtDFRsRTNsNAs
S315-p DFRsRTNsNAstVsG
S318-p sRTNsNAstVsGRLS
T319-p RTNsNAstVsGRLSP
S321-p NsNAstVsGRLSPIM
S344-p QDDDAPLsPMLYSSS
T395-p DDLLDNItLPPsQPS
S399-p DNItLPPsQPSPTGG
S413-p GLMQRSSsFPYTTKG
G420 sFPYTTKGsGLGsPt
S421-p FPYTTKGsGLGsPtS
S425-p TKGsGLGsPtSSFNS
T427-p GsGLGsPtSSFNSTV
S429 GLGsPtSSFNSTVFG
T433 PtSSFNSTVFGPSsL
S439-p STVFGPSsLNSLRQS
S551-p LGGSRALsNSVsNMG
S555-p RALsNSVsNMGLSES
K569-ac SSSLGSAkHQQQsPV
S574-p SAkHQQQsPVSQSMQ
S588-p QTLSDSLsGSSLYST
S626-p SLECDMEsIIRSELM
S644-p GLDFNFDsLISTQNV
2599 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
8174 : Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb
  rat

 
S7-p _MAEAPAsPVPLsPL
S12-p PAsPVPLsPLEVELD
- under review  
S30 EPQSRPRSCtWPLQR
T32-p QSRPRSCtWPLQRPE
S43 QRPELQASPAKPSGE
S48 QASPAKPSGETAADS
S55 SGETAADSMIPEEDD
S89 GVSSALGSGLLLEDS
S160 RNAWGNLSYADLITR
Y161 NAWGNLSYADLITRA
T178 SSPDKRLTLSQIYEW
Y183 RLTLSQIYEWMVRCV
S208 SSAGWKNSIRHNLSL
S214 NSIRHNLSLHSRFMR
S230 QNEGTGKSSWWIINP
S231 NEGTGKSSWWIINPD
K241 IINPDGGKSGKAPRR
S242 INPDGGKSGKAPRRR
S252-p APRRRAVsMDNSNkY
K258-ac VsMDNSNkYTKSRGR
K270 RGRAAKKKAALQAAP
S279 ALQAAPESADDsPSQ
S283-p APESADDsPSQLSKW
S285 ESADDsPSQLSKWPG
S288 DDsPSQLSKWPGsPT
K289 DsPSQLSKWPGsPTS
S293-p QLSKWPGsPTSRSSD
T295 SKWPGsPTSRSSDEL
S296 KWPGsPTSRSSDELD
S298 PGsPTSRSSDELDAW
S299 GsPTSRSSDELDAWT
T306 SDELDAWTDFRSRTN
S310 DAWTDFRSRTNSNAS
S314 DFRSRTNSNASTVSG
S317 SRTNSNASTVSGRLS
T318 RTNSNASTVSGRLSP
S320 NSNASTVSGRLSPIL
S343 QDDDGPLSPMLYSSS
A394 DDLLDNIALPPSQAS
S398 DNIALPPSQASPPGG
S412 GLMQRSSSFPYTAKS
S419 SFPYTAKSSGLGSPT
S420 FPYTAKSSGLGSPTS
S424 AKSSGLGSPTSSFNS
T426 SSGLGSPTSSFNSTV
S428 GLGSPTSSFNSTVFG
T432 PTSSFNSTVFGPASL
S438 STVFGPASLNSLRQS
S550 LGGSRALSNSVSNMG
S554 RALSNSVSNMGLSDS
K568 SSSLGSAKHQQQSPV
S573 SAKHQQQSPVSQSMQ
S587 QTLSDSLSGSSLYSA
S625 SLECDMESIIRSELM
S643 GLDFNFDSLISTQNV
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
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