a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Transcription factor; DNA binding protein
Molecular Function: protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding; DNA bending activity
Biological Process: transcription from RNA polymerase II promoter; tissue development; transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; initiation of primordial ovarian follicle growth; apoptosis; positive regulation of erythrocyte differentiation; antral ovarian follicle growth; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; ovulation from ovarian follicle; glucose homeostasis; pattern specification process; oocyte maturation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; regulation of translation; embryonic development; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.