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FOXO3A (mouse)

Overview FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor; Autophagy Cellular Component: transcription factor complex; membrane; cytoplasm; cytosol; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding; protein kinase binding; DNA bending activity Biological Process: tissue development; DNA damage response, signal transduction by p53 class mediator; transcription, DNA-dependent; initiation of primordial ovarian follicle growth; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of erythrocyte differentiation; antral ovarian follicle growth; negative regulation of transcription from RNA polymerase II promoter; ovulation from ovarian follicle; glucose homeostasis; pattern specification process; oocyte maturation; regulation of cell proliferation; regulation of translation; embryonic development; regulation of transcription factor activity; regulation of transcription, DNA-dependent; induction of apoptosis; insulin receptor signaling pathway; response to stress; positive regulation of transcription from RNA polymerase II promoter Reference #:  Q9WVH4 (UniProtKB) Alt. Names/Synonyms: 1110048B16Rik; 2010203A17Rik; C76856; Fkhr2; FKHRL1; forkhead box O3; Forkhead box O3a; Forkhead protein FKHR2; Foxo3; Foxo3a; OTTMUSP00000022929; OTTMUSP00000022930; Putative uncharacterized protein Gene Symbols: Foxo3 Molecular weight: 71,064 Da Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  GPCRs Signaling to MAPK/Erk  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXO3A 2K86 - A=151-251 (human) 2UZK - A/C=158-253 (human)

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	Sites Implicated In
apoptosis, altered: T32‑p apoptosis, inhibited: T32‑p cell cycle regulation: T32‑p cell growth, altered: T32‑p cytoskeletal reorganization: T32‑p transcription, altered: T32‑p intracellular localization: T32‑p, S314‑p, S317‑p, S320‑p molecular association, regulation: T32‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	23		S7-p	_MAEAPAsPVPLsPL
1	18		S12-p	PAsPVPLsPLEVELD
0	2		S30	EPQSRPRSCtWPLQR
54	82		T32-p	QSRPRSCtWPLQRPE
0	2		S43-p	QRPELQAsPAKPsGE
0	1		S48-p	QAsPAKPsGETAADs
0	1		S55-p	sGETAADsMIPEEDD
1	0		S89-p	GVSSTLGsGLLLEDS
0	1		Y161	NAWGNLSYADLITRA
2	0		T178	SSPDKRLTLSQIYEW
0	5		Y183	RLTLSQIYEWMVRCV
3	0		S208	SSAGWKNSIRHNLSL
1	1		S214	NSIRHNLSLHSRFMR
1	0		S230	QNEGTGKSSWWIINP
1	0		S231	NEGTGKSSWWIINPD
2	0		K241-a	IINPDGGkSGKAPRR
1	0		S242	INPDGGkSGKAPRRR
17	64		S252-p	APRRRAVsMDNSNkY
2	0		K258-a	VsMDNSNkYTKSRGR
1	0		K270-a	RGRAAKKkAALQAAP
0	5		S279-p	ALQAAPEsADDsPsQ
1	12		S283-p	APEsADDsPsQLSkW
0	2		S285-p	EsADDsPsQLSkWPG
0	2		S288	DDsPsQLSkWPGsPt
2	0		K289-a	DsPsQLSkWPGsPtS
3	69		S293-p	QLSkWPGsPtSRssD
0	1		T295-p	SkWPGsPtSRssDEL
0	2		S296	kWPGsPtSRssDELD
0	3		S298-p	PGsPtSRssDELDAW
1	2		S299-p	GsPtSRssDELDAWT
3	1		S314-p	DFRSRTNsNAsTVsG
5	1		S317-p	SRTNsNAsTVsGRLS
0	1		T318	RTNsNAsTVsGRLSP
6	0		S320-p	NsNAsTVsGRLSPIL
2	1		S343	QDDDGPLSPMLYSSS
0	1		A394	DDLLDNIALPPSQPS
2	0		S398	DNIALPPSQPSPPGG
4	1		S412-p	GLMQRGSsFPYTAKs
0	1		S419-p	sFPYTAKsSGLGsPt
0	2		S420	FPYTAKsSGLGsPtG
3	3		S424-p	AKsSGLGsPtGSFNS
1	2		T426-p	sSGLGsPtGSFNSTV
0	1		S438	STVFGPSSLNSLRQS
0	1		S550	LGGSRALSNSVSNMG
2	0		S554	RALSNSVSNMGLSDS
2	0		K568-a	SSSLGSAkHQQQsPA
1	0		S573-p	SAkHQQQsPASQSMQ
2	0		S587	QTLSDSLSGSSLYSA
3	0		S625	SLECDMESIIRSELM
1	0		S643	GLDFNFDSLISTQNV

	human
S7-p	_MAEAPAsPAPLsPL
S12-p	PAsPAPLsPLEVELD
S30-p	EPQSRPRsCtWPLQR
T32-p	QSRPRsCtWPLQRPE
S43-p	QRPELQAsPAKPSGE
S48	QAsPAKPSGETAADS
S55	SGETAADSMIPEEED
S90	GGSGTLGSGLLLEDS
Y162-p	NAWGNLSyADLITRA
T179-p	SSPDKRLtLSQIyEW
Y184-p	RLtLSQIyEWMVRCV
S209-p	SSAGWKNsIRHNLsL
S215-p	NsIRHNLsLHSRFMR
S231-p	QNEGTGKssWWIINP
S232-p	NEGTGKssWWIINPD
K242-a	IINPDGGksGKAPRR
S243-p	INPDGGksGKAPRRR
S253-p	APRRRAVsMDNSNkY
K259-a	VsMDNSNkYTKSRGR
K271	RGRAAKKKAALQTAP
S280-p	ALQTAPEsADDsPsQ
S284-p	APEsADDsPsQLskW
S286-p	EsADDsPsQLskWPG
S289-p	DDsPsQLskWPGsPt
K290-a	DsPsQLskWPGsPts
S294-p	QLskWPGsPtsRsSD
T296-p	skWPGsPtsRsSDEL
S297-p	kWPGsPtsRsSDELD
S299-p	PGsPtsRsSDELDAW
S300	GsPtsRsSDELDAWT
S315-p	DFRSRTNsNAstVsG
S318-p	SRTNsNAstVsGRLS
T319-p	RTNsNAstVsGRLSP
S321-p	NsNAstVsGRLSPIM
S344-p	QDDDAPLsPMLYSSS
T395-p	DDLLDNItLPPsQPS
S399-p	DNItLPPsQPSPTGG
S413-p	GLMQRSSsFPYTTKG
G420	sFPYTTKGsGLGsPt
S421-p	FPYTTKGsGLGsPtS
S425-p	TKGsGLGsPtSSFNS
T427-p	GsGLGsPtSSFNSTV
S439-p	STVFGPSsLNSLRQS
S551-p	LGGSRALsNSVsNMG
S555-p	RALsNSVsNMGLSES
K569-a	SSSLGSAkHQQQSPV
S574	SAkHQQQSPVSQSMQ
S588-p	QTLSDSLsGSSLYST
S626-p	SLECDMEsIIRSELM
S644-p	GLDFNFDsLISTQNV

	rat
S7	_MAEAPASPVPLSPL
S12	PASPVPLSPLEVELD
S30	EPQSRPRSCtWPLQR
T32-p	QSRPRSCtWPLQRPE
S43	QRPELQASPAKPSGE
S48	QASPAKPSGETAADS
S55	SGETAADSMIPEEDD
S89	GVSSALGSGLLLEDS
Y161	NAWGNLSYADLITRA
T178	SSPDKRLTLSQIYEW
Y183	RLTLSQIYEWMVRCV
S208	SSAGWKNSIRHNLSL
S214	NSIRHNLSLHSRFMR
S230	QNEGTGKSSWWIINP
S231	NEGTGKSSWWIINPD
K241	IINPDGGKSGKAPRR
S242	INPDGGKSGKAPRRR
S252-p	APRRRAVsMDNSNKY
K258	VsMDNSNKYTKSRGR
K270	RGRAAKKKAALQAAP
S279	ALQAAPESADDSPSQ
S283	APESADDSPSQLSKW
S285	ESADDSPSQLSKWPG
S288	DDSPSQLSKWPGsPT
K289	DSPSQLSKWPGsPTS
S293-p	QLSKWPGsPTSRSSD
T295	SKWPGsPTSRSSDEL
S296	KWPGsPTSRSSDELD
S298	PGsPTSRSSDELDAW
S299	GsPTSRSSDELDAWT
S314	DFRSRTNSNASTVSG
S317	SRTNSNASTVSGRLS
T318	RTNSNASTVSGRLSP
S320	NSNASTVSGRLSPIL
S343	QDDDGPLSPMLYSSS
A394	DDLLDNIALPPSQAS
S398	DNIALPPSQASPPGG
S412	GLMQRSSSFPYTAKS
S419	SFPYTAKSSGLGSPT
S420	FPYTAKSSGLGSPTS
S424	AKSSGLGSPTSSFNS
T426	SSGLGSPTSSFNSTV
S438	STVFGPASLNSLRQS
S550	LGGSRALSNSVSNMG
S554	RALSNSVSNMGLSDS
K568	SSSLGSAKHQQQSPV
S573	SAKHQQQSPVSQSMQ
S587	QTLSDSLSGSSLYSA
S625	SLECDMESIIRSELM
S643	GLDFNFDSLISTQNV

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