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CENPA (mouse)

Overview CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: kinetochore; inner kinetochore of condensed chromosome; nucleosome; chromosome; nucleus; chromosome, pericentric region; condensed nuclear chromosome, pericentric region Molecular Function: DNA binding; protein heterodimerization activity Biological Process: nucleosome assembly; kinetochore assembly; establishment of mitotic spindle orientation Reference #:  O35216 (UniProtKB) Alt. Names/Synonyms: CENP-A; Cenpa; centromere autoantigen A; Centromere protein A; centrosomin A; Histone H3-like centromeric protein A; OTTMUSP00000025185 Gene Symbols: Cenpa Molecular weight: 15,509 Da Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CENPA 3AN2 - A/E=1-140 (human) 3NQJ - A=60-140 (human) 3NQU - A=1-140 (human) 3R45 - A=1-140 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
12	0		-	gap
0	13		-	gap
0	13		S15-p	QTPRRRPssPAPGPS
0	9		S16-p	TPRRRPssPAPGPSR
0	3		S22	ssPAPGPSRQSSSVG
0	1		R36	GSQTLRRRQKFMWLK

	human
S7-p	_MGPRRRsRKPEAPR
S17-p	PEAPRRRsPsPtPTP
S19-p	APRRRsPsPtPTPGP
T21-p	RRRsPsPtPTPGPsR
S27-p	PtPTPGPsRRGPSLG
R42-m1	ASSHQHSrRRQGWLK

	rat
-	gap
-	gap
S16	TPRRRPSSPAPGPSQ
S41	TPTRRPSSPAPGPSR
S47	SSPAPGPSRRSSGVG
R61	GPQALHRRRRFLWLK

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