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Protein Page:
ORC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ORC2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with MCM10. Belongs to the ORC2 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Cellular Component: nucleoplasm; heterochromatin; membrane; inner kinetochore of condensed chromosome; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex
Molecular Function: protein binding; DNA replication origin binding
Biological Process: DNA replication initiation; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; DNA replication; G1/S transition of mitotic cell cycle
Reference #:  Q13416 (UniProtKB)
Alt. Names/Synonyms: ORC2; ORC2L; origin of replication 2-like; origin recognition complex protein 2 homolog; Origin recognition complex subunit 2; origin recognition complex, subunit 2-like (yeast)
Gene Symbols: ORC2
Molecular weight: 65,972 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ORC2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T116‑p, T226‑p
molecular association, regulation: T116‑p, T226‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 14 K47-ac AQLLVNPkKIIKKPE
0 3 Y70-p EVLKDQNyVEIMGRD
0 12 Y95-p TGGGNKVysFQNRKH
0 3 S96-p GGGNKVysFQNRKHS
0 1 S111-p EKMAKLAsELAKtPQ
3 17 T116-p LAsELAKtPQKSVsF
0 3 S122-p KtPQKSVsFsLKNDP
0 2 S124-p PQKSVsFsLKNDPEI
0 1 S138-p ITINVPQsSKGHSAS
0 1 S165-p FLSTAPRsLRKRLIV
2 0 S188-p SEYSASNsEDDEGVA
0 2 S219-p QAQNRVVsAPVGKEt
3 24 T226-p sAPVGKEtPSKRMKR
0 6 T236-p KRMKRDKtsDLVEEy
0 2 S237-p RMKRDKtsDLVEEyF
0 14 Y243-p tsDLVEEyFEAHsss
0 1 S248-p EEyFEAHsssKVLTs
0 1 S249-p EyFEAHsssKVLTsD
0 1 S250-p yFEAHsssKVLTsDR
0 3 S255-p sssKVLTsDRtLQKL
0 1 T258-p KVLTsDRtLQKLKRA
0 6 S280-p RNLLSKVsPsFsAEL
0 1 S282-p LLSKVsPsFsAELKQ
0 1 S284-p SKVsPsFsAELKQLN
0 1 S475-p QSGSLPLsSLTHVLR
0 1 S483-p SLTHVLRsLTPNARG
0 1 S528-p REAFLVNsDLtLRAQ
0 1 T531-p FLVNsDLtLRAQLTE
  mouse

 
Q47 AQLLVNPQKVIKKAD
Y70 EVLEDQNYVKVLGRN
Y95 KDGRNKVYSFQQRKH
S96 DGRNKVYSFQQRKHP
L111 EEMTKLALELAKTSG
T116 LALELAKTSGKKDPL
P122 KTSGKKDPLDSNDPE
D124 SGKKDPLDSNDPEIT
K137 ITKNIAQKSKGHSTS
N164 FLSTQPHNLRKRIIA
S187-p SEYSASSsEDDEEAT
P218 QGQNRLLPAPVSKET
T225 PAPVSKETLPKKKKR
A235 KKKKRDKASDLVEEY
S236 KKKRDKASDLVEEYF
Y242 ASDLVEEYFEAHSSS
S247 EEYFEAHSSSKVLTS
S248 EYFEAHSSSKVLTSD
S249 YFEAHSSSKVLTSDR
S254 SSSKVLTSDRTLQRL
T257 KVLTSDRTLQRLRRA
V279 HNLLRKFVPSFSAEI
S281 LLRKFVPSFSAEIER
S283 RKFVPSFSAEIERLN
S474 QSGSLPLSSLIHVLR
S482 SLIHVLRSLTPNARG
S527 REAFLVNSDLTLRAQ
T530 FLVNSDLTLRAQLTE
  rat

 
Q47 VQLLVNPQKVIKKAE
Y70 EVLEDQNYVEVLGRN
Y95 VDGRNKVYSFQHRKH
S96 DGRNKVYSFQHRKHP
L111 EEMTKLALELAKTSG
T116 LALELAKTSGKIDPL
P122 KTSGKIDPLASNDPK
A124 SGKIDPLASNDPKIT
K137 ITKNIARKSKGHSSE
N163 FPSIQPHNVRKRLIA
S186 SEYSASSSEDDEEVA
P217 QGQNRLLPAPVSKEI
I224 PAPVSKEILPKKRKR
A234 KKRKRDKAGDLVEEY
G235 KRKRDKAGDLVEEYF
Y241 AGDLVEEYFEAHSSS
S246 EEYFEAHSSSKVLTS
S247 EYFEAHSSSKVLTSD
S248 YFEAHSSSKVLTSDR
S253 SSSKVLTSDRTLQKL
T256 KVLTSDRTLQKLRRA
V278 RNLLSKFVPSFSTEI
S280 LLSKFVPSFSTEIGQ
S282 SKFVPSFSTEIGQLN
S473 QSGSLPLSSLIHVLR
S481 SLIHVLRSLTPNARG
S526 REAFLVNSDLTLRAQ
T529 FLVNSDLTLRAQLTE
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