Home

ORC2 (human)

Overview ORC2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with MCM10. Belongs to the ORC2 family. Note: This description may include information from UniProtKB. Protein type: DNA replication Cellular Component: nucleoplasm; heterochromatin; inner kinetochore of condensed chromosome; nucleus; nuclear origin of replication recognition complex; origin recognition complex Molecular Function: protein binding; DNA replication origin binding Biological Process: DNA replication initiation; M/G1 transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; DNA replication; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  Q13416 (UniProtKB) Alt. Names/Synonyms: ORC2; ORC2L; origin of replication 2-like; origin recognition complex protein 2 homolog; Origin recognition complex subunit 2; origin recognition complex, subunit 2-like (yeast) Gene Symbols: ORC2 Molecular weight: 65,972 Da Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ORC2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: T116‑p, T226‑p molecular association, regulation: T116‑p, T226‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	14		K47-a	AQLLVNPkKIIKKPE
0	2		Y70-p	EVLKDQNyVEIMGRD
0	10		Y95-p	TGGGNKVysFQNRKH
0	2		S96-p	GGGNKVysFQNRKHS
2	13		T116-p	LASELAKtPQKSVsF
0	1		S122-p	KtPQKSVsFsLKNDP
0	2		S124-p	PQKSVsFsLKNDPEI
0	1		S138-p	ITINVPQsSKGHSAS
0	1		S165-p	FLSTAPRsLRKRLIV
2	0		S188-p	SEYSASNsEDDEGVA
0	1		S219-p	QAQNRVVsAPVGKEt
2	19		T226-p	sAPVGKEtPSKRMKR
0	5		T236-p	KRMKRDKtsDLVEEy
0	2		S237-p	RMKRDKtsDLVEEyF
0	12		Y243-p	tsDLVEEyFEAHSss
0	1		S249-p	EyFEAHSssKVLTSD
0	1		S250-p	yFEAHSssKVLTSDR
0	3		S280-p	RNLLSKVsPsFSAEL
0	1		S282-p	LLSKVsPsFSAELKQ
0	1		S475-p	QSGSLPLsSLTHVLR
0	1		S483-p	SLTHVLRsLTPNARG
0	1		Y508	DNQDNPSYIGLSFQD
0	1		S528-p	REAFLVNsDLtLRAQ
0	1		T531-p	FLVNsDLtLRAQLTE

	mouse
Q47	AQLLVNPQKVIKKAD
Y70	EVLEDQNYVKVLGRN
Y95	KDGRNKVYSFQQRKH
S96	DGRNKVYSFQQRKHP
T116	LALELAKTSGKKDPL
P122	KTSGKKDPLDSNDPE
D124	SGKKDPLDSNDPEIT
K137	ITKNIAQKSKGHSTS
N164	FLSTQPHNLRKRIIA
S187-p	SEYSASSsEDDEEAT
P218	QGQNRLLPAPVSKET
T225	PAPVSKETLPKKKKR
A235	KKKKRDKASDLVEEY
S236	KKKRDKASDLVEEYF
Y242	ASDLVEEYFEAHSSS
S248	EYFEAHSSSKVLTSD
S249	YFEAHSSSKVLTSDR
V279	HNLLRKFVPSFSAEI
S281	LLRKFVPSFSAEIER
S474	QSGSLPLSSLIHVLR
S482	SLIHVLRSLTPNARG
Y507	DNQDSPSYIGLSFQD
S527	REAFLVNSDLTLRAQ
T530	FLVNSDLTLRAQLTE

	rat
Q47	VQLLVNPQKVIKKAE
Y70	EVLEDQNYVEVLGRN
Y95	VDGRNKVYSFQHRKH
S96	DGRNKVYSFQHRKHP
T116	LALELAKTSGKIDPL
P122	KTSGKIDPLASNDPK
A124	SGKIDPLASNDPKIT
K137	ITKNIARKSKGHSSE
N163	FPSIQPHNVRKRLIA
S186	SEYSASSSEDDEEVA
P217	QGQNRLLPAPVSKEI
I224	PAPVSKEILPKKRKR
A234	KKRKRDKAGDLVEEY
G235	KRKRDKAGDLVEEYF
Y241	AGDLVEEYFEAHSSS
S247	EYFEAHSSSKVLTSD
S248	YFEAHSSSKVLTSDR
V278	RNLLSKFVPSFSTEI
S280	LLSKFVPSFSTEIGQ
S473	QSGSLPLSSLIHVLR
S481	SLIHVLRSLTPNARG
Y506-p	DNQDCPSyIGLSFQD
S526	REAFLVNSDLTLRAQ
T529	FLVNSDLTLRAQLTE

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.