May have an important role in DNA metabolism. Interacts with TOP3A and TOP3B. Ubiquitous. Belongs to the helicase family. RecQ subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Helicase; EC 220.127.116.11; DNA repair, damage; EC 3.6.1.-
Cellular Component: nucleoplasm; cytoplasm; DNA-directed RNA polymerase II, holoenzyme; nucleus
Molecular Function: DNA helicase activity; nucleic acid binding; ATP-dependent helicase activity; ATP binding
Biological Process: mitosis; DNA repair; DNA replication; DNA metabolic process; chromosome separation; DNA duplex unwinding; DNA recombination
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.