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Protein Page:
RECQL5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RECQL5 May have an important role in DNA metabolism. Interacts with TOP3A and TOP3B. Ubiquitous. Belongs to the helicase family. RecQ subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; EC 3.6.1.-; Helicase; DNA repair, damage
Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleolus; DNA-directed RNA polymerase II, holoenzyme; nucleus
Molecular Function: DNA helicase activity; nucleic acid binding; ATP-dependent helicase activity; ATP binding
Biological Process: ATP catabolic process; mitosis; DNA replication; DNA repair; DNA metabolic process; DNA duplex unwinding; chromosome separation; DNA recombination
Reference #:  O94762 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent DNA helicase Q5; DNA helicase, RecQ-like type 5; FLJ90603; RecQ protein 5; RecQ protein-like 5; RECQ5; RECQL5
Gene Symbols: RECQL5
Molecular weight: 108,858 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RECQL5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2 ______MSSHHTTFP
0 1 T7 _MSSHHTTFPFDPER
0 1 F8 MSSHHTTFPFDPERR
0 1 K22-ub RVRSTLKkVFGFDsF
0 1 S28-p KkVFGFDsFKtPLQE
0 1 T31-p FGFDsFKtPLQEsAT
0 1 S36-p FKtPLQEsATMAVVK
0 1 S144 SFQPTLNSLVSRHLL
0 1 S147 PTLNSLVSRHLLSYL
0 3 T456-p RSSSWSKtCIGPsQG
0 6 S461-p SKtCIGPsQGNGFDP
0 1 Y478-p YEGGRKGyGDFSRyD
0 1 Y484-p GyGDFSRyDEGsGGs
0 7 S488-p FSRyDEGsGGsGDEG
0 6 S491-p yDEGsGGsGDEGRDE
0 1 Y508-p KREWNLFyQKQMQLR
0 2 V526 DPKIEEFVPPDENCP
0 1 T568-p LSSNRQStRtADEAD
0 1 T570-p SNRQStRtADEADLR
0 1 T676-p ATELMETtRIREQAP
0 10 S727-p SAHYGGPsPEKKAKS
0 6 S774-p FFCRRVEsPALLASA
0 1 C788 APEAEGACPSCEGVQ
0 7 S815-p EDGAGGHsPAPPQTE
0 7 T839-p CPPRDQGtPEVQPtP
0 2 T845-p GtPEVQPtPAKDTWK
0 1 S858-p WKGKRPRsQQENPES
  mouse

 
S2-p ______MsARPFstP
S7-p _MsARPFstPFDRER
T8-p MsARPFstPFDRERR
K22 RVRSTLKKVFGFDSF
S28 KKVFGFDSFKTPLQE
T31 FGFDSFKTPLQESAT
S36 FKTPLQESATMAVVK
S144-p SFQPTLNsLVsRNLL
S147-p PTLNsLVsRNLLSYL
T457 RSSSWSKTCIGPSQG
S462 SKTCIGPSQGNGFDP
Y479 YEGGRRGYGGFSRYD
Y485 GYGGFSRYDEGSGGS
S489 FSRYDEGSGGSGDEG
S492 YDEGSGGSGDEGRDE
Y509 KREWNLFYQKQMSLR
T527-p EPKIEEFtPPDEDCP
A569 LISNHQAAGSTHGAD
S571 SNHQAAGSTHGADLQ
S677 ATELLGKSHSQKQAP
S728-p SVNCGDPsPEKKTKG
S773-p FLCQRTEsPPLPASV
S787-p VPRSEDAsPSCGDVP
L807 EVGAQGHLVAVFQTE
F830 CSLRDQSFPEGQPSP
S836 SFPEGQPSPLKETQA
P849 QAEKRPRPQQGNPER
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