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RECQL5 (human)

Overview RECQL5 May have an important role in DNA metabolism. Interacts with TOP3A and TOP3B. Ubiquitous. Belongs to the helicase family. RecQ subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA repair; EC 3.6.1.-; EC 3.6.4.12; Helicase Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleolus; DNA-directed RNA polymerase II, holoenzyme; nucleus Molecular Function: DNA helicase activity; nucleic acid binding; ATP-dependent helicase activity; ATP binding Biological Process: DNA repair; DNA metabolic process; DNA duplex unwinding; DNA recombination Reference #:  O94762 (UniProtKB) Alt. Names/Synonyms: ATP-dependent DNA helicase Q5; DNA helicase, RecQ-like type 5; FLJ90603; RecQ protein 5; RecQ protein-like 5; RECQ5; RECQL5 Gene Symbols: RECQL5 Molecular weight: 108,858 Da Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RECQL5

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S2-p	______MsSHHTtFP
0	1		T7-p	_MsSHHTtFPFDPER
0	1		F8	MsSHHTtFPFDPERR
0	1		K22-u	RVRSTLKkVFGFDsF
0	1		S28-p	KkVFGFDsFKtPLQE
0	1		T31-p	FGFDsFKtPLQEsAT
0	1		S36-p	FKtPLQEsATMAVVK
0	1		S144	SFQPTLNSLVSRHLL
0	1		S147	PTLNSLVSRHLLSYL
0	2		T456-p	RSSSWSKtCIGPsQG
0	2		S461-p	SKtCIGPsQGNGFDP
0	1		Y478-p	YEGGRKGyGDFSRyD
0	1		Y484-p	GyGDFSRyDEGsGGs
0	4		S488-p	FSRyDEGsGGsGDEG
0	3		S491-p	yDEGsGGsGDEGRDE
0	1		Y508-p	KREWNLFyQKQMQLR
0	1		V526	DPKIEEFVPPDENCP
0	1		T568-p	LSSNRQStRtADEAD
0	1		T570-p	SNRQStRtADEADLR
0	3		S727-p	SAHYGGPsPEKKAKS
0	3		S774	FFCRRVESPALLASA
0	3		S815-p	EDGAGGHsPAPPQTE
0	4		T839-p	CPPRDQGtPEVQPTP

	mouse
S2-p	______MsARPFstP
S7-p	_MsARPFstPFDRER
T8-p	MsARPFstPFDRERR
K22	RVRSTLKKVFGFDSF
S28	KKVFGFDSFKTPLQE
T31	FGFDSFKTPLQESAT
S36	FKTPLQESATMAVVK
S144-p	SFQPTLNsLVsRNLL
S147-p	PTLNsLVsRNLLSYL
T457	RSSSWSKTCIGPSQG
S462	SKTCIGPSQGNGFDP
Y479	YEGGRRGYGGFSRYD
Y485	GYGGFSRYDEGSGGS
S489	FSRYDEGSGGSGDEG
S492	YDEGSGGSGDEGRDE
Y509	KREWNLFYQKQMSLR
T527-p	EPKIEEFtPPDEDCP
A569	LISNHQAAGSTHGAD
S571	SNHQAAGSTHGADLQ
S728-p	SVNCGDPsPEKKTKG
S773-p	FLCQRTEsPPLPASV
L807	EVGAQGHLVAVFQTE
F830	CSLRDQSFPEGQPSP

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