Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 22.214.171.124; Phosphatase; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Cellular Component: cell-cell adherens junction; perinuclear region of cytoplasm; lamellipodium; integral to plasma membrane; cytoplasm; intercellular junction
Molecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; homophilic cell adhesion; signal transduction; protein amino acid dephosphorylation; positive regulation of vasodilation; neurite development; retinal ganglion cell axon guidance
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.