a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; EC 188.8.131.52; Phosphatase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18p11.2
Cellular Component: cell-cell adherens junction; perinuclear region of cytoplasm; integral to plasma membrane; lamellipodium; cytoplasm; intercellular junction
Molecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of vasodilation; signal transduction; homophilic cell adhesion; protein amino acid dephosphorylation; neurite development; retinal ganglion cell axon guidance
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.