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Protein Page:
PTPRM (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PTPRM Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 3.1.3.48; Phosphatase; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Cellular Component: cell-cell adherens junction; perinuclear region of cytoplasm; lamellipodium; integral to plasma membrane; cytoplasm; intercellular junction
Molecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; homophilic cell adhesion; signal transduction; protein amino acid dephosphorylation; positive regulation of vasodilation; neurite development; retinal ganglion cell axon guidance
Reference #:  P28827 (UniProtKB)
Alt. Names/Synonyms: hR-PTPu; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; Protein-tyrosine phosphatase mu; PTPRL1; PTPRM; R-PTP-mu; Receptor-type tyrosine-protein phosphatase mu; RPTPM; RPTPU
Gene Symbols: PTPRM
Molecular weight: 163,682 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTPRM

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S536-p EIDLSNQsGRVSKLG
0 5 T637-p PRRTKKTtEILKCYP
0 1 S820 NLNGRSVSsPSsFTM
0 2 S821-p LNGRSVSsPSsFTMK
0 3 S824-p RSVSsPSsFTMKTNT
0 66 Y929-p ENRMKNRyGNIIAyD
0 14 Y935-p RyGNIIAyDHSRVRL
0 1 K1373 KLIRQVDKWQEEYNG
  mouse

 
S536 EIDLSNQSGRVSKLG
T637 PRRTKKTTEILKCYP
S820-p NLNGRSVssPSsFTM
S821-p LNGRSVssPSsFTMK
S824-p RSVssPSsFTMKTNT
Y929-p ENRMKNRyGNIIAYD
Y935 RyGNIIAYDHSRVRL
K1373-u KLIRQVDkWQEEYNG
  rat

 
S536 EIDLSNQSGRVSKLG
T637 PRRTKKTTEILKCYP
S845 NLNGRSVSSPSSFTM
S846 LNGRSVSSPSSFTMK
S849 RSVSSPSSFTMKTNT
Y963-p ENRMKNRyGNIIAYD
Y969 RyGNIIAYDHSRVRL
K1407 KLIRQVDKWQEEYNG
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