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Protein Page:
PTPRM (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTPRM a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor protein phosphatase, tyrosine; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.48
Cellular Component: cell-cell adherens junction; integral to plasma membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; intercellular junction
Molecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; signal transduction; homophilic cell adhesion; protein amino acid dephosphorylation; positive regulation of vasodilation; neurite development; retinal ganglion cell axon guidance
Reference #:  P28827 (UniProtKB)
Alt. Names/Synonyms: hR-PTPu; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; Protein-tyrosine phosphatase mu; PTPRL1; PTPRM; R-PTP-mu; Receptor-type tyrosine-protein phosphatase mu; RPTPM; RPTPU
Gene Symbols: PTPRM
Molecular weight: 163,682 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTPRM

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S524-p EITYKAVssFDPEID
0 1 S525-p ITYKAVssFDPEIDL
0 1 S533-p FDPEIDLsNQsGRVs
0 2 S536-p EIDLsNQsGRVsKLG
0 1 S540-p sNQsGRVsKLGNETH
0 5 T637-p PRRTKKTtEILKCYP
0 1 S778 KKRKETMSSTRQEMt
0 1 T785-p SSTRQEMtVMVNSMD
0 2 S820-p NLNGRSVssPSsFTM
0 3 S821-p LNGRSVssPSsFTMK
0 3 S824-p RSVssPSsFTMKTNT
0 1 T847-p YYPDETHtMASDTsS
0 1 S853-p HtMASDTsSLVQSHT
0 1 T873 PADVPYQTGQLHPAI
0 75 Y929-p ENRMKNRyGNIIAyD
0 12 Y935-p RyGNIIAyDHSRVRL
0 1 K1373 KLIRQVDKWQEEYNG
  mouse

 
S524 EITYKAVSSFDPEID
S525 ITYKAVSSFDPEIDL
S533 FDPEIDLSNQSGRVS
S536 EIDLSNQSGRVSKLG
S540 SNQSGRVSKLGNETH
T637 PRRTKKTTEILKCYP
S778-p KKRKETMsSTRQEMT
T785 sSTRQEMTVMVNSMD
S820-p NLNGRSVssPSsFTM
S821-p LNGRSVssPSsFTMK
S824-p RSVssPSsFTMKTNT
T847 YYPDETHTMASDTSS
S853 HTMASDTSSLAQPHT
T873-p AADVPYQtGQLHPAI
Y929-p ENRMKNRyGNIIAYD
Y935 RyGNIIAYDHSRVRL
K1373-ub KLIRQVDkWQEEYNG
  rat

 
S524 EITYKAVSSFDPEID
S525 ITYKAVSSFDPEIDL
S533 FDPEIDLSNQSGRVS
S536 EIDLSNQSGRVSKLG
S540 SNQSGRVSKLGNETH
T637 PRRTKKTTEILKCYP
S803 KKRKETMSSTRQEMT
T810 SSTRQEMTVMVNSMD
S845 NLNGRSVSSPSSFTM
S846 LNGRSVSSPSSFTMK
S849 RSVSSPSSFTMKTNT
T881 AILDETHTMASDTSS
S887 HTMASDTSSLAQPHT
T907 AADVPYQTGQLHPAI
Y963-p ENRMKNRyGNIIAYD
Y969 RyGNIIAYDHSRVRL
K1407 KLIRQVDKWQEEYNG
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