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PTPRM (human)

Overview PTPRM Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Note: This description may include information from UniProtKB. Protein type: Phosphatase; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; EC 3.1.3.48; Membrane protein, integral Cellular Component: cell-cell adherens junction; perinuclear region of cytoplasm; lamellipodium; integral to plasma membrane; cytoplasm; intercellular junction Molecular Function: protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; protein amino acid dephosphorylation; homophilic cell adhesion; positive regulation of vasodilation; signal transduction; neurite development; retinal ganglion cell axon guidance Reference #:  P28827 (UniProtKB) Alt. Names/Synonyms: hR-PTPu; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; Protein-tyrosine phosphatase mu; PTPRL1; PTPRM; R-PTP-mu; Receptor-type tyrosine-protein phosphatase mu; RPTPM; RPTPU Gene Symbols: PTPRM Molecular weight: 163,682 Da Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PTPRM 1RPM - A/B=879-1156 (human) 2C9A - A=21-279 (human) 2V5Y - A=21-742 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1RPM 2C9A 2V5Y  |  ENZYME  |  Phospho3D  |  DISEASE  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S524-p	EITYKAVssFDPEID
0	1		S525-p	ITYKAVssFDPEIDL
0	1		S533-p	FDPEIDLsNQsGRVs
0	2		S536-p	EIDLsNQsGRVsKLG
0	1		S540-p	sNQsGRVsKLGNETH
0	5		T637-p	PRRTKKTtEILKCYP
0	1		S778	KKRKETMSSTRQEMt
0	1		T785-p	SSTRQEMtVMVNSMD
0	1		S820	NLNGRSVSsPSsFTM
0	2		S821-p	LNGRSVSsPSsFTMK
0	3		S824-p	RSVSsPSsFTMKTNT
0	1		T847-p	YYPDETHtMASDTsS
0	1		S853-p	HtMASDTsSLVQSHT
0	65		Y929-p	ENRMKNRyGNIIAyD
0	14		Y935-p	RyGNIIAyDHSRVRL
0	1		K1373	KLIRQVDKWQEEYNG

	mouse
S524	EITYKAVSSFDPEID
S525	ITYKAVSSFDPEIDL
S533	FDPEIDLSNQSGRVS
S536	EIDLSNQSGRVSKLG
S540	SNQSGRVSKLGNETH
T637	PRRTKKTTEILKCYP
S778-p	KKRKETMsSTRQEMT
T785	sSTRQEMTVMVNSMD
S820-p	NLNGRSVssPSsFTM
S821-p	LNGRSVssPSsFTMK
S824-p	RSVssPSsFTMKTNT
T847	YYPDETHTMASDTSS
S853	HTMASDTSSLAQPHT
Y929	ENRMKNRYGNIIAYD
Y935	RYGNIIAYDHSRVRL
K1373-u	KLIRQVDkWQEEYNG

	rat
S524	EITYKAVSSFDPEID
S525	ITYKAVSSFDPEIDL
S533	FDPEIDLSNQSGRVS
S536	EIDLSNQSGRVSKLG
S540	SNQSGRVSKLGNETH
T637	PRRTKKTTEILKCYP
S803	KKRKETMSSTRQEMT
T810	SSTRQEMTVMVNSMD
S845	NLNGRSVSSPSSFTM
S846	LNGRSVSSPSSFTMK
S849	RSVSSPSSFTMKTNT
T881	AILDETHTMASDTSS
S887	HTMASDTSSLAQPHT
Y963-p	ENRMKNRyGNIIAYD
Y969	RyGNIIAYDHSRVRL
K1407	KLIRQVDKWQEEYNG

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