A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phosphatase; EC 126.96.36.199; Motility/polarity/chemotaxis; EC 188.8.131.52; Cofactor and Vitamin Metabolism - riboflavin
Cellular Component: multivesicular body; extracellular space; Golgi cisterna; lysosomal membrane; apical part of cell; integral to membrane; plasma membrane; intracellular; vesicle membrane; nucleus; secretory granule; filopodium
Molecular Function: 5'-nucleotidase activity; identical protein binding; choline binding; acid phosphatase activity; protein binding; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity
Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.