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Protein Page:
ACPP (human)

Overview
ACPP A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.5; EC 3.1.3.2; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - riboflavin; Phosphatase
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: multivesicular body; extracellular space; Golgi cisterna; apical part of cell; lysosomal membrane; plasma membrane; integral to membrane; intracellular; vesicle membrane; nucleus; filopodium; secretory granule
Molecular Function: 5'-nucleotidase activity; choline binding; identical protein binding; acid phosphatase activity; protein binding; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity
Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process
Reference #:  P15309 (UniProtKB)
Alt. Names/Synonyms: acid phosphatase, prostate; ACP-3; ACP3; ACPP; PAP; PPAP; Prostatic acid phosphatase; prostatic acid phosphotase
Gene Symbols: ACPP
Molecular weight: 44,566 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACPP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T171-p FQELESEtLKSEEFQ
0 1 T231-p PSWATEDtMtKLREL
0 1 T233-p WATEDtMtKLRELsE
0 1 S239-p MtKLRELsELSLLSL
  mouse

 
T170 FEELKSETLESEEFL
A230 PSWATEDAMIKLKEL
I232 WATEDAMIKLKELSE
S238 MIKLKELSELSLLSL
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