A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phosphatase; EC 184.108.40.206; Cofactor and Vitamin Metabolism - riboflavin; EC 220.127.116.11; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: multivesicular body; extracellular space; Golgi cisterna; lysosomal membrane; apical part of cell; plasma membrane; integral to membrane; intracellular; vesicle membrane; nucleus; secretory granule; filopodium
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.