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Protein Page:
NMDAR2D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NMDAR2D NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; startle response; adult locomotory behavior; ionotropic glutamate receptor signaling pathway; regulation of sensory perception of pain; signal transduction
Reference #:  O15399 (UniProtKB)
Alt. Names/Synonyms: EB11; estrogen receptor binding CpG island; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; GRIN2D; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D; NMDE4; NR2D
Gene Symbols: GRIN2D
Molecular weight: 143,752 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Select Structure to View Below

NMDAR2D

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K516-ub TNGKHGKkIDGVWNG
0 1 K620-ub NRSLATGkRPGGSTF
0 1 K697 VSGLSDRKFQRPQEQ
0 1 K697-ub VSGLSDRkFQRPQEQ
0 1 K720-ub VPNGSTEkNIRSNYP
0 1 Y732-p NYPDMHSyMVRyNQP
0 1 Y736-p MHSyMVRyNQPRVEE
0 1 K749-ub EEALTQLkAGKLDAF
0 2 K795-ub GYGIALHkGSRWKRP
0 4 Y964 LADGFHRYYGPIEPQ
0 4 Y965 ADGFHRYYGPIEPQG
0 2 S1054 RLAFEDESPPAPARW
0 1 S1154 PPPGRYWSVDkLGGW
0 1 K1157-ub GRYWSVDkLGGWRAG
0 4 S1271 PPAPTSRSLEDLSSC
0 9 T1288-p AAPARRLtGPSRHAR
0 1 R1316 TASHRRHRGGDLGTR
0 4 S1326 DLGTRRGSAHFSSLE
  mouse

 
K513 TNGKHGKKIDGVWNG
K617 NRSLATGKRPGGSTF
K694-ac VSGLSDRkFQRPQEQ
K694 VSGLSDRKFQRPQEQ
K717 VPNGSTEKNIRSNYP
Y729 NYPDMHSYMVRYNQP
Y733 MHSYMVRYNQPRVEE
K746 EEALTQLKAGKLDAF
K792 GYGIALHKGSRWKRP
Y961 LADGFHRYYGPIEPQ
Y962 ADGFHRYYGPIEPQG
S1049-p RLAFEDEsPPAPSRW
S1143-p PPPGRYWsVDKLGGW
K1146 GRYWsVDKLGGWRAG
S1258-p PPAPTSRsLEDLSSC
T1275-p AAPTRRLtGPSRHAR
R1303-m1 TASHRRHrGGDLGTR
S1313-p DLGTRRGsAHFSSLE
  rat

 
K513 TNGKHGKKIDGVWNG
K617 NRSLATGKRPGGSTF
K694 VSGLSDRKFQRPQEQ
K694 VSGLSDRKFQRPQEQ
K717 VPNGSTEKNIRSNYP
Y729 NYPDMHSYMVRYNQP
Y733 MHSYMVRYNQPRVEE
K746 EEALTQLKAGKLDAF
K792 GYGIALHKGSRWKRP
Y961-p IADGFHRyyGPIEPQ
Y962-p ADGFHRyyGPIEPQG
S1049 RLAFEDESPPAPSRW
S1143 PPPGRYWSVDKLGGW
K1146 GRYWSVDKLGGWRAG
S1258 PPAPTSRSLEDLSSC
T1275 AAPTRRLTGPSRHAR
R1303 TASHRRHRGGDLGTR
S1313 DLGTRRGSAHFSSLE
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