regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Kinase, lipid; Enzyme, regulatory subunit
Molecular Function: protein phosphatase binding; transcription factor binding; ATPase binding; calmodulin binding; insulin binding; insulin-like growth factor receptor binding; receptor binding; protein C-terminus binding; protein domain specific binding; neurotrophin TRKA receptor binding; 1-phosphatidylinositol-3-kinase activity; platelet-derived growth factor receptor binding; phosphoprotein binding; 1-phosphatidylinositol-3-kinase regulator activity; phosphoinositide 3-kinase regulator activity; receptor tyrosine kinase binding; protein kinase binding; insulin receptor binding; protein binding; ErbB-3 class receptor binding; protein heterodimerization activity; insulin receptor substrate binding; ubiquitin protein ligase binding; estrogen receptor binding; phosphoinositide 3-kinase binding
Biological Process: negative regulation of osteoclast differentiation; phosphoinositide 3-kinase cascade; response to cAMP; negative regulation of heart rate; negative regulation of smooth muscle cell proliferation; response to glucocorticoid stimulus; signal transduction; NFAT protein import into nucleus; positive regulation of RNA splicing; regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; response to insulin stimulus; protein transport; phosphoinositide phosphorylation; transport; positive regulation of transcription factor import into nucleus; negative regulation of blood pressure; negative regulation of proteolysis; protein stabilization; glucose metabolic process; negative regulation of cell-matrix adhesion; positive regulation of tumor necrosis factor production; positive regulation of myoblast differentiation; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; B cell differentiation; insulin receptor signaling pathway; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell-cell adhesion; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.