Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
JAG2 (human)

Overview
JAG2 Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding
Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; cell differentiation; auditory receptor cell fate commitment; skeletal development; T cell differentiation; gamma-delta T cell differentiation
Reference #:  Q9Y219 (UniProtKB)
Alt. Names/Synonyms: hJ2; JAG2; jagged 2; Jagged2; Protein jagged-2; SER2
Gene Symbols: JAG2
Molecular weight: 133,367 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JAG2

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S35-p GYFELQLsALRNVNG
0 1 Y202-p RVRCDENyySATCNK
0 1 Y203-p VRCDENyySATCNKF
0 1 S1059-p AITQRGNssLLLAVt
0 1 S1060-p ITQRGNssLLLAVtE
0 1 T1066-p ssLLLAVtEVKVETV
0 2 S1123-p SRLPREEsANNQWAP
0 3 T1155-p LYQCKNFtPPPRRAD
0 2 S1208-p FTKDPGRsPGRPAHW
  mouse

 
S35 GYFELQLSALRNVNG
Y202 RVRCDENYYSATCNK
Y203 VRCDENYYSATCNKF
S1061 AITQRGNSSLLLAVT
S1062 ITQRGNSSLLLAVTE
T1068 SSLLLAVTEVKVETV
S1125 SRLPRDESANNQWAP
T1164 LYQCKNFTPPPRRAG
S1217 FTKDPSCSLGRPARW
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.