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JAG2 (human)

Overview JAG2 Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell surface; Membrane protein, integral Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; regulation of apoptosis; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; cell differentiation; auditory receptor cell fate commitment; skeletal development; T cell differentiation Reference #:  Q9Y219 (UniProtKB) Alt. Names/Synonyms: hJ2; JAG2; jagged 2; Jagged2; Protein jagged-2; SER2 Gene Symbols: JAG2 Molecular weight: 133,367 Da Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states CST Pathways:  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JAG2

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S35-p	GYFELQLsALRNVNG
0	1		Y202-p	RVRCDENyySATCNK
0	1		Y203-p	VRCDENyySATCNKF
0	1		S1059-p	AITQRGNssLLLAVt
0	1		S1060-p	ITQRGNssLLLAVtE
0	1		T1066-p	ssLLLAVtEVKVETV
0	1		S1123-p	SRLPREEsANNQWAP
0	1		T1155-p	LYQCKNFtPPPRRAD

	mouse
S35	GYFELQLSALRNVNG
Y202	RVRCDENYYSATCNK
Y203	VRCDENYYSATCNKF
S1061	AITQRGNSSLLLAVT
S1062	ITQRGNSSLLLAVTE
T1068	SSLLLAVTEVKVETV
S1125	SRLPRDESANNQWAP
T1164	LYQCKNFTPPPRRAG

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