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MMP7 (human)

Overview MMP7 Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Protease; EC 3.4.24.23; Secreted Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region Molecular Function: zinc ion binding; metalloendopeptidase activity Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; defense response to Gram-positive bacterium; extracellular matrix organization and biogenesis; proteolysis; defense response to Gram-negative bacterium; antibacterial peptide secretion; regulation of cell proliferation Reference #:  P09237 (UniProtKB) Alt. Names/Synonyms: Matrilysin; Matrin; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7 (matrilysin, uterine); Matrix metalloproteinase-7; MMP-7; MMP7; MPSL1; PUMP-1; Pump-1 protease; PUMP1; uterine matrilysin; Uterine metalloproteinase Gene Symbols: MMP7 Molecular weight: 29,677 Da Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  GPCRs Signaling to MAPK/Erk

Select Structure to View Below MMP7 1MMP - A/B=95-264 (human) 1MMQ - A=95-264 (human) 1MMR - A=95-264 (human) 2DDY - A=95-267 (human) 2Y6C - A=95-258 (human) 2Y6D - A=95-267 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1MMP 1MMQ 1MMR 2DDY 2Y6C 2Y6D  |  ENZYME  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S47-p	KRFYLYDsEtKNANS
0	1		T49-p	FYLYDsEtKNANSLE
0	1		K84-a	RVIEIMQkPRCGVPD

	mouse
S47	RKFYPHDSKTKKVNS
T49	FYPHDSKTKKVNSLV
K84	YIMEIMQKPRCGVPD

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