Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; EC 184.108.40.206; Protease
Chromosomal Location of Human Ortholog: 11q21-q22
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity
Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; defense response to Gram-positive bacterium; extracellular matrix organization and biogenesis; antibacterial peptide biosynthetic process; proteolysis; defense response to Gram-negative bacterium; antibacterial peptide secretion; regulation of cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.