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Protein Page:
TRPV3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRPV3 Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: plasma membrane; integral to membrane; receptor complex
Molecular Function: calcium channel activity
Biological Process: negative regulation of hair cycle; response to heat; transmembrane transport
Reference #:  Q8NET8 (UniProtKB)
Alt. Names/Synonyms: Transient receptor potential cation channel subfamily V member 3; transient receptor potential cation channel, subfamily V, member 3; TRPV3; vanilloid receptor 3; Vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein; VRL-3; VRL3
Gene Symbols: TRPV3
Molecular weight: 90,636 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRPV3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K29-ac NPAILPEkRPAEITP
0 1 K358-ub MGKAEILkYILSREI
0 2 S374-p EKRLRSLsRKFtDWA
0 1 T378-p RSLsRKFtDWAyGPV
0 1 Y382-p RKFtDWAyGPVSsSL
0 1 S387-p WAyGPVSsSLYDLTN
0 1 T421 DNRHEMLTLEPLHTL
0 1 T427 LTLEPLHTLLHMKWK
0 1 M431 PLHTLLHMKWKKFAK
  mouse

 
K29 NPVVLTEKRPADLTP
K358 MGKAEILKYILSREI
S374 EKPLRSLSRKFTDWA
T378 RSLSRKFTDWAYGPV
Y382 RKFTDWAYGPVSSSL
S387 WAYGPVSSSLYDLTN
T421-p DNRHEMLtLEPLHtL
T427-p LtLEPLHtLLHtKWK
T431-p PLHtLLHtKWKKFAK
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