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Protein Page:
PKCA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PKCA an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; EC 2.7.11.13; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily
Cellular Component: nucleoplasm; photoreceptor outer segment; cell soma; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; mitochondrial membrane; dendrite; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; enzyme binding; protein kinase C activity; zinc ion binding; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity
Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; regulation of muscle contraction; positive regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of insulin receptor signaling pathway; positive regulation of mitotic cell cycle; signal transduction; protein amino acid phosphorylation; induction of positive chemotaxis; synaptic transmission; negative regulation of cell proliferation; RNA metabolic process; chondrocyte differentiation; angiogenesis; cell adhesion; positive regulation of macrophage differentiation; regulation of peptidyl-tyrosine phosphorylation; regulation of the force of heart contraction; inactivation of MAPK activity; epidermal growth factor receptor signaling pathway; neutrophil chemotaxis; platelet activation; fibroblast growth factor receptor signaling pathway; negative regulation of adenylate cyclase activity; adenylate cyclase activation; positive regulation of blood vessel endothelial cell migration; mRNA metabolic process; rhodopsin mediated signaling; cellular calcium ion homeostasis; positive regulation of angiogenesis; negative regulation of glucose import; regulation of rhodopsin mediated signaling; phospholipase C activation; energy reserve metabolic process; innate immune response; gene expression; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; blood coagulation; regulation of insulin secretion; positive regulation of inflammatory response
Reference #:  P17252 (UniProtKB)
Alt. Names/Synonyms: AAG6; aging-associated gene 6; KPCA; MGC129900; MGC129901; PKC-A; PKC-alpha; PKCA; PRKACA; PRKCA; Protein kinase C alpha type; protein kinase C, alpha
Gene Symbols: PRKCA
Molecular weight: 76,750 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKCA

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
intracellular localization: T638‑p, S657‑p, Y658‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p DVFPGNDsTASQDVA
0 4 K45 KFIARFFKQPtFCSH
0 4 T48-p ARFFKQPtFCSHCTD
0 2 T176-p ADEKLHVtVRDAKNL
0 116 Y195-p PNGLSDPyVKLKLIP
0 2 K197 GLSDPyVKLKLIPDP
0 3 K199 SDPyVKLKLIPDPKN
0 1 S208-p IPDPKNEsKQKTKtI
0 1 S208 IPDPKNESKQKTKtI
0 1 T212 KNEsKQKTKtIRSTL
0 4 T214-p EsKQKTKtIRSTLNP
0 56 S226-p LNPQWNEsFtFKLKP
0 12 T228-p PQWNEsFtFKLKPSD
0 1 S234 FtFKLKPSDKDRRLS
0 31 Y285-p LNQEEGEyyNVPIPE
0 7 Y286-p NQEEGEyyNVPIPEG
0 2 K316 KLGPAGNKVIsPsED
0 14 S319-p PAGNKVIsPsEDRKQ
0 2 S321-p GNKVIsPsEDRKQPS
0 1 T337 NLDRVKLTDFNFLMV
0 1 S349 LMVLGKGSFGKVMLA
0 1 T361 MLADRKGTEELyAIK
0 23 Y365-p RKGTEELyAIKILKK
0 1 T384 QDDDVECTMVEKRVL
0 1 T401 LDKPPFLTQLHSCFQ
0 1 S405 PFLTQLHSCFQTVDR
0 1 T409 QLHSCFQTVDRLYFV
0 2 R462 HKRGIIYRDLKLDNV
2 3 T494-p EHMMDGVttRtFCGt
2 11 T495-p HMMDGVttRtFCGtP
6 65 T497-p MDGVttRtFCGtPDy
0 20 T501-p ttRtFCGtPDyIAPE
0 20 Y504-p tFCGtPDyIAPEIIA
0 11 Y512-p IAPEIIAyQPyGKSV
0 3 Y515-p EIIAyQPyGKSVDWW
0 1 K570-a KEAVSVCkGLMTKHP
0 1 T574 SVCkGLMTKHPAKRL
0 1 K604-a FRRIDWEkLENREIQ
0 1 K628-a KGAENFDkFFTRGQP
0 1 K628-u KGAENFDkFFTRGQP
18 6 T638-p TRGQPVLtPPDQLVI
0 3 S651-p VIANIDQsDFEGFsy
22 4 S657-p QsDFEGFsyVNPQFV
4 0 Y658-p sDFEGFsyVNPQFVH
0 1 S670 FVHPILQSAV_____
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9375 : Phospho-PKCalpha/beta II (Thr638/641) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  mouse

 
S10 DVYPANDSTASQDVA
K45 KFIARFFKQPtFCSH
T48-p ARFFKQPtFCSHCTD
T176 TDEKLHVTVRDAKNL
Y195-p PNGLSDPyVkLkLIP
K197-u GLSDPyVkLkLIPDP
K199-u SDPyVkLkLIPDPKN
S208 IPDPKNESKQKTKTI
S208 IPDPKNESKQKTKTI
T212 KNESKQKTKTIRSTL
T214 ESKQKTKTIRSTLNP
S226-p LNPQWNEsFtFKLKP
T228-p PQWNEsFtFKLKPSD
S234 FtFKLKPSDKDRRLS
Y285-p LNQEEGEyYNVPIPE
Y286 NQEEGEyYNVPIPEG
K316 KLGPAGNKVIsPsED
S319-p PAGNKVIsPsEDRKQ
S321-p GNKVIsPsEDRKQPS
T337 NLDRVKLTDFNFLMV
S349 LMVLGKGSFGKVMLA
T361 MLADRKGTEELYAIK
Y365 RKGTEELYAIKILKK
T384 QDDDVECTMVEKRVL
T401 LDKPPFLTQLHSCFQ
S405 PFLTQLHSCFQTVDR
T409 QLHSCFQTVDRLYFV
R462-m1 HKRGIIYrDLKLDNV
T494-p EHMMDGVttRtFCGt
T495-p HMMDGVttRtFCGtP
T497-p MDGVttRtFCGtPDy
T501-p ttRtFCGtPDyIAPE
Y504-p tFCGtPDyIAPEIIA
Y512 IAPEIIAYQPYGKSV
Y515 EIIAYQPYGKSVDWW
K570 KEAVSICKGLMTKHP
T574 SICKGLMTKHPAKRL
K604 FRRIDWEKLENREIQ
K628 KGAENFDKFFTRGQP
K628 KGAENFDKFFTRGQP
T638-p TRGQPVLtPPDQLVI
S651-p VIANIDQsDFEGFsy
S657-p QsDFEGFsyVNPQFV
Y658-p sDFEGFsyVNPQFVH
S670-p FVHPILQsAV_____
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9375 : Phospho-PKCalpha/beta II (Thr638/641) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  rat

 
S10 DVYPANDSTASQDVA
K45-u KFIARFFkQPTFCSH
T48 ARFFkQPTFCSHCTD
T176 TDEKLHVTVRDAKNL
Y195-p PNGLSDPyVkLkLIP
K197-u GLSDPyVkLkLIPDP
K199-u SDPyVkLkLIPDPKN
S208 IPDPKNESKQKtKTI
S208-gl IPDPKNEsKQKtKTI
T212-gl KNEsKQKtKTIRSTL
T214 EsKQKtKTIRSTLNP
S226-p LNPQWNEsFTFKLKP
T228 PQWNEsFTFKLKPsD
S234-gl FTFKLKPsDKDRRLS
Y285-p LNQEEGEyyNVPIPE
Y286-p NQEEGEyyNVPIPEG
K316-u KLGPAGNkVISPSED
S319 PAGNkVISPSEDRKQ
S321 GNkVISPSEDRKQPS
T337-gl NLDRVKLtDFNFLMV
S349-gl LMVLGKGsFGKVMLA
T361-gl MLADRKGtEELyAIK
Y365-p RKGtEELyAIKILKK
T384-gl QDDDVECtMVEKRVL
T401-gl LDKPPFLtQLHsCFQ
S405-gl PFLtQLHsCFQtVDR
T409-gl QLHsCFQtVDRLYFV
R462 HKRGIIYRDLKLDNV
T494 EHMMDGVTTRtFCGT
T495 HMMDGVTTRtFCGTP
T497-p MDGVTTRtFCGTPDy
T501 TTRtFCGTPDyIAPE
Y504-p tFCGTPDyIAPEIIA
Y512-p IAPEIIAyQPyGKSV
Y515-p EIIAyQPyGKSVDWW
K570 KEAVSICKGLMtKHP
T574-gl SICKGLMtKHPAKRL
K604 FRRIDWEKLENREIQ
K628 KGAENFDKFFTRGQP
K628 KGAENFDKFFTRGQP
T638-p TRGQPVLtPPDQLVI
S651 VIANIDQSDFEGFsY
S657-p QSDFEGFsYVNPQFV
Y658 SDFEGFsYVNPQFVH
S670 FVHPILQSAV_____
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  cow

 
P10 DVFPAAEPAAPQDVA
K45 RFIARFFKQPTFCSH
T48 ARFFKQPTFCSHCTD
T176 TDEKLHVTVRDAKNL
Y195 PNGLSDPYVKLKLIP
K197 GLSDPYVKLKLIPDP
K199 SDPYVKLKLIPDPKN
S208 IPDPKNESKQKTKTI
S208 IPDPKNESKQKTKTI
T212 KNESKQKTKTIRSTL
T214 ESKQKTKTIRSTLNP
S226 LNPRWDESFTFKLKP
T228 PRWDESFTFKLKPSD
S234 FTFKLKPSDKDRRLS
Y285 LNQEEGEYYNVPIPE
Y286 NQEEGEYYNVPIPEG
K316 KLGPAGNKVISPSED
S319 PAGNKVISPSEDRRQ
S321 GNKVISPSEDRRQPS
T337 NLDRVKLTDFNFLMV
S349 LMVLGKGSFGKVMLA
T361 MLADRKGTEELYAIK
Y365 RKGTEELYAIKILKK
T384 QDDDVECTMVEKRVL
T401 LDKPPFLTQLHSCFQ
S405 PFLTQLHSCFQTVDR
T409 QLHSCFQTVDRLYFV
R462 HKRGIIYRDLKLDNV
T494-p EHMMDGVttRtFCGT
T495-p HMMDGVttRtFCGTP
T497-p MDGVttRtFCGTPDY
T501 ttRtFCGTPDYIAPE
Y504 tFCGTPDYIAPEIIA
Y512 IAPEIIAYQPYGKSV
Y515 EIIAYQPYGKSVDWW
K570 KEAVSICKGLMTKHP
T574 SICKGLMTKHPGKRL
K604 FRRIDWEKLENREIQ
K628 KGAENFDKFFTRGQP
K628 KGAENFDKFFTRGQP
T638-p TRGQPVLtPPDQLVI
S651 VIANIDQSDFEGFsY
S657-p QSDFEGFsYVNPQFV
Y658 SDFEGFsYVNPQFVH
S670 FVHPILQSAV_____
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
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