an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 18.104.22.168; AGC group; PKC family; Alpha subfamily
Cellular Component: nucleoplasm; photoreceptor outer segment; protein complex; cell soma; endoplasmic reticulum; perinuclear region of cytoplasm; dendrite; mitochondrial membrane; cytoplasm; plasma membrane; cytosol; lipid raft
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; zinc ion binding; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; response to antibiotic; chondrocyte differentiation; cell adhesion; positive regulation of macrophage differentiation; regulation of the force of heart contraction; inactivation of MAPK activity; response to corticosterone stimulus; neutrophil chemotaxis; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of blood vessel endothelial cell migration; adenylate cyclase activation; regulation of receptor-mediated endocytosis; mRNA metabolic process; positive regulation of synaptogenesis; response to reactive oxygen species; positive regulation of angiogenesis; response to ethanol; response to mechanical stimulus; phospholipase C activation; positive regulation of endothelial cell proliferation; response to peptide hormone stimulus; negative regulation of heart contraction; regulation of muscle contraction; positive regulation of smooth muscle cell proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of mitotic cell cycle; signal transduction; response to estradiol stimulus; induction of positive chemotaxis; negative regulation of cell proliferation; synaptic transmission; learning and/or memory; RNA metabolic process; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; aging; positive regulation of exocytosis; epidermal growth factor receptor signaling pathway; central nervous system neuron axonogenesis; negative regulation of adenylate cyclase activity; cellular calcium ion homeostasis; negative regulation of glucose import; peptidyl-serine phosphorylation; negative regulation of translation; energy reserve metabolic process; gene expression; positive regulation of protein amino acid phosphorylation; blood coagulation; regulation of insulin secretion; positive regulation of inflammatory response
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.