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FOXA2
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: transcription factor complex; cytoplasm; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein domain specific binding; DNA binding; double-stranded DNA binding; SMAD binding; DNA bending activity; transcription factor activity; transcription factor binding
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Biological Process: adult locomotory behavior; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter by glucose; response to insulin stimulus; negative regulation of glucokinase activity; anterior/posterior pattern formation; cell differentiation in hindbrain; ectoderm formation; regulation of transcription factor activity; neuron fate specification; positive regulation of transcription from RNA polymerase II promoter by glucose; dorsoventral neural tube patterning; in utero embryonic development; negative regulation of transcription factor activity; chromatin modification; somite rostral/caudal axis specification; oligodendrocyte cell fate commitment; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; positive regulation of embryonic development; myelin formation in the central nervous system; regulation of blood coagulation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; endoderm development
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Reference #:
Q9Y261 (UniProtKB)
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| Alt. Names/Synonyms: forkhead box A2; Forkhead box protein A2; FOXA2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; HNF3B; MGC19807; TCF-3B; TCF3B; Transcription factor 3B |
| Gene Symbols: FOXA2 |
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Molecular weight: 48,306 Da
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Basal Isoelectric point: 8.82
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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