Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
FOXA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXA2 Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: cytoplasm; nucleus
Molecular Function: protein domain specific binding; DNA binding; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; adult locomotory behavior; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter by glucose; negative regulation of glucokinase activity; cell differentiation in hindbrain; ectoderm formation; regulation of steroid metabolic process; positive regulation of smoothened signaling pathway; neuron fate specification; positive regulation of transcription from RNA polymerase II promoter by glucose; dorsoventral neural tube patterning; in utero embryonic development; negative regulation of transcription factor activity; chromatin modification; somite rostral/caudal axis specification; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; positive regulation of embryonic development; regulation of blood coagulation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell development
Reference #:  Q9Y261 (UniProtKB)
Alt. Names/Synonyms: forkhead box A2; Forkhead box protein A2; FOXA2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; HNF3B; MGC19807; TCF-3B; TCF3B; Transcription factor 3B
Gene Symbols: FOXA2
Molecular weight: 48,306 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXA2

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
carcinogenesis, induced: S107‑p, S111‑p
cell growth, induced: S107‑p, S111‑p
signaling pathway regulation: S107‑p, S111‑p
transcription, altered: T156‑p
transcription, inhibited: S107‑p, S111‑p
intracellular localization: T156‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K6-ac __MLGAVkMEGHEPS
1 0 K6 __MLGAVKMEGHEPS
0 1 S59 GSGSGNMSAGSMNMS
1 1 S107-p AGMGPHLsPSLsPLG
1 1 S111-p PHLsPSLsPLGGQAA
2 0 T156-p KTYRRSYtHAKPPYS
0 1 S212-p NSIRHSLsFNDCFLK
0 3 S223-p CFLKVPRsPDKPGKG
0 1 Y248-p NMFENGCyLRRQKRF
0 1 K256-ac LRRQKRFkCEkQLAL
2 0 K259-ac QKRFkCEkQLALkEA
1 1 K264-ac CEkQLALkEAAGAAG
1 1 K274-ac AGAAGSGkkAAAGAQ
2 1 K275-ac GAAGSGkkAAAGAQA
1 0 S283 AAAGAQASQAQLGEA
0 1 S295-p GEAAGPAsETPAGtE
0 2 T301-p AsETPAGtEsPHSsA
0 3 S303-p ETPAGtEsPHSsAsP
0 2 S306 AGtEsPHSsAsPCQE
0 3 S307-p GtEsPHSsAsPCQEH
0 4 S309-p EsPHSsAsPCQEHKR
0 1 S436 NKTGLDASPLAADTS
0 1 S457 SRPIMNSS_______
  mouse

 
K6 __MLGAVKMEGHEPS
K6 __MLGAVKMEGHEPS
S59-p GGGSGNMsAGSMNMS
S107 AGMGPHLSPSLSPLG
S111 PHLSPSLSPLGGQAA
T156 KTYRRSYTHAKPPYS
S212 NSIRHSLSFNDCFLK
S223-p CFLKVPRsPDKPGKG
Y248 NMFENGCYLRRQKRF
K256 LRRQKRFKCEKQLAL
K259 QKRFKCEKQLALKEA
K264 CEKQLALKEAAGAAS
K275 GAASSGGKKTAPGSQ
K276 AASSGGKKTAPGSQA
S284 TAPGSQASQAQLGEA
S296 GEAAGSASETPAGtE
T302-p ASETPAGtEsPHssA
S304-p ETPAGtEsPHssAsP
S307-p AGtEsPHssAsPCQE
S308-p GtEsPHssAsPCQEH
S310-p EsPHssAsPCQEHKR
S438 NKAGLDASPLAADTS
S459 SRPIMNSS_______
  rat

 
K6 __MLGAVKMEGHEPS
K6-sm __MLGAVkMEGHEPS
S59 GSGSGNMSAGSMNMS
S107 AGMGPHLSPSLSPLG
S111 PHLSPSLSPLGGQAA
T156 KTYRRSYTHAKPPYS
S212-p NSIRHSLsFNDFLKV
A222 DFLKVPRAPDKPGKG
Y247 NMFENGCYLRRQKRF
K255 LRRQKRFKCENELAL
N258 QKRFKCENELALKEA
K263 CENELALKEAAGAGS
K274 GAGSGGGKKTAPGTQ
K275 AGSGGGKKTAPGTQA
S283-p TAPGTQAsQVQLGEA
S295 GEAAGSASETPAGTE
T301 ASETPAGTEsPHssA
S303-p ETPAGTEsPHssAsP
S306-p AGTEsPHssAsPCQE
S307-p GTEsPHssAsPCQEH
S309-p EsPHssAsPCQEHKR
S437-p NKAGLDAsPLAADTS
S458-p SRPIMNSs_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.