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Protein Page:
DTNBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DTNBP1 The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16980328). Interacts with RNF151 and CMYA5. Identified in a complex with the adapter-related protein complex 3 (AP-3). Interacts with TRIM32, AP3M1 and AP3B2. Identified in a complex with the biogenesis of lysosome-related organelles complex 2 (BLOC-2). Interacts with the DNA-dependent protein kinase complex DNA-PK. Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3. Belongs to the dysbindin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: endoplasmic reticulum membrane; neuron projection; synaptic vesicle membrane; postsynaptic density; melanosome membrane; dendritic spine; cytosol; postsynaptic membrane; growth cone; axon; cytoplasm; endosome membrane; sarcoplasm; cell junction; nucleus; sarcolemma
Molecular Function: protein binding
Biological Process: platelet dense granule organization and biogenesis; melanosome organization and biogenesis; regulation of dopamine receptor signaling pathway; actin cytoskeleton reorganization; anterograde synaptic vesicle transport; post-Golgi vesicle-mediated transport; blood coagulation; anterograde axon cargo transport; regulation of dopamine secretion; positive regulation of neurotransmitter secretion; neurite development; neurite morphogenesis
Reference #:  Q96EV8 (UniProtKB)
Alt. Names/Synonyms: DBND; DKFZp564K192; DTBP1; DTNBP1; Dysbindin; Dysbindin-1; dystrobrevin binding protein 1; Dystrobrevin-binding protein 1; FLJ30031; Hermansky-Pudlak syndrome 7 protein; HPS7; HPS7 protein; MGC20210; My031; SDY
Gene Symbols: DTNBP1
Molecular weight: 39,493 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DTNBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 97 S11-p TLRERLLsVQQDFTS
0 1 K31-ac SDKSREAkVkSkPRT
0 1 K33-ac KSREAkVkSkPRTVP
0 1 K35-ac REAkVkSkPRTVPFL
0 1 S113-p ALIADLEsMtANLtH
0 1 T115-p IADLEsMtANLtHLE
0 1 T119-p EsMtANLtHLEAsFE
0 1 S124-p NLtHLEAsFEEVENN
0 2 S297-p ELRAKPPsSSSTCtD
0 1 T303-p PsSSSTCtDSATRDI
0 7 S316-p DISEGGEsPVVQsDE
0 7 S321-p GEsPVVQsDEEEVQV
0 2 T342 SHTDREATPDGGEDS
0 4 G346 REATPDGGEDSDS__
0 4 S349 TPDGGEDSDS_____
0 1 - gap
0 1 - gap
  mouse

 
S11-p TLRERLLsVQQDFTS
K31 SDKSREAKVKGKPRT
K33 KSREAKVKGKPRTAP
K35 REAKVKGKPRTAPRL
S113 ALLQDLESLMASLAH
M115 LQDLESLMASLAHLE
A119 ESLMASLAHLETSFE
S124 SLAHLETSFEEVENH
A297 ESASQPPASPSACTD
T303 PASPSACTDLDTADA
- gap
S315 ADAPLIQSDEEEVQV
T336-p LHTDRKStPGVsDDs
S340-p RKStPGVsDDsDQCD
S343-p tPGVsDDsDQCDstQ
S348-p DDsDQCDstQDI___
T349-p DsDQCDstQDI____
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