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Protein Page:
MRLC2V (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MRLC2V myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. Note: This description may include information from UniProtKB.
Protein type: Contractile protein
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: sarcomere; cytoskeleton; myofibril; myosin complex; cytosol; A band; actin cytoskeleton
Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding
Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; post-embryonic development; muscle filament sliding; cardiac muscle contraction
Reference #:  P10916 (UniProtKB)
Alt. Names/Synonyms: cardiac ventricular myosin light chain 2; CMH10; DKFZp779C0562; MLC-2; MLC-2v; MLC2; MLRV; MYL2; myosin light chain 2; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow; regulatory light chain of myosin; RLC of myosin; slow cardiac myosin regulatory light chain 2
Gene Symbols: MYL2
Molecular weight: 18,789 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

MRLC2V

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K8 MAPKKAKKRAGGANs
0 5 N14 KKRAGGANsNVFsMF
4 18 S15-p KRAGGANsNVFsMFE
1 0 S15 KRAGGANSNVFsMFE
2 3 S19-p GANsNVFsMFEQTQI
0 1 T24 VFsMFEQTQIQEFKE
0 3 K46 NRDGFIDKNDLRDTF
0 2 K62 ALGRVNVKNEEIDEM
0 1 K91 TMFGEKLKGADPEET
0 40 K104-ac ETILNAFkVFDPEGk
0 2 K111-ac kVFDPEGkGVLKADy
0 1 K111 kVFDPEGKGVLKADy
0 1 V113 FDPEGkGVLKADyVR
0 2 K115 PEGkGVLKADyVREM
0 129 Y118-p kGVLKADyVREMLtT
0 1 T124-p DyVREMLtTQAERFS
0 1 T125 yVREMLtTQAERFSK
0 1 K132 TQAERFSKEEVDQMF
0 2 Y152-p DVTGNLDykNLVHII
0 2 K153-ac VTGNLDykNLVHIIT
0 53 K165-ac IITHGEEkD______
0 2 K165 IITHGEEKD______
  mouse

 
K8-ub MAPKKAKkRIEGGss
S14-p KkRIEGGssNVFsMF
S15-p kRIEGGssNVFsMFE
S15 kRIEGGsSNVFsMFE
S19-p GGssNVFsMFEQtQI
T24-p VFsMFEQtQIQEFKE
K46-ub NRDGFIDkNDLRDTF
K62-ub ALGRVNVkNEEIDEM
K91-ub TMFGEKLkGADPEET
K104 ETILNAFKVFDPEGk
K111 KVFDPEGKGsLkADy
K111-ub KVFDPEGkGsLkADy
S113-p FDPEGkGsLkADyVR
K115-ub PEGkGsLkADyVREM
Y118-p kGsLkADyVREMLTt
T124 DyVREMLTtQAERFS
T125-p yVREMLTtQAERFSk
K132-ub tQAERFSkEEIDQMF
Y152 DVTGNLDYKNLVHII
K153 VTGNLDYKNLVHIIT
K165-ac IITHGEEkD______
K165-ub IITHGEEkD______
  rat

 
K8 MSPKKAKKRLEGGss
S14-p KKRLEGGssNVFSMF
S15-p KRLEGGssNVFSMFE
S15-gl KRLEGGssNVFSMFE
S19 GGssNVFSMFEQTQI
T24 VFSMFEQTQIQEFKE
K46 NRDGFIDKNDLRDTF
K62 ALGRVNVKNEEIDEM
K91 TMFGEKLKGADPEET
K104 ETILNAFKVFDPEGK
K111 KVFDPEGKGsLKADy
K111 KVFDPEGKGsLKADy
S113-p FDPEGKGsLKADyVR
K115 PEGKGsLKADyVREM
Y118-p KGsLKADyVREMLTT
T124 DyVREMLTTQAERFS
T125 yVREMLTTQAERFSK
K132 TQAERFSKEEIDQMF
Y152 DVTGNLDYKNLVHII
K153 VTGNLDYKNLVHIIT
K165-ac IITHGEEkD______
K165 IITHGEEKD______
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