Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: cytoplasm
Molecular Function: mRNA binding; protein binding; translation repressor activity
Biological Process: negative regulation of translational initiation; spermatogenesis; memory
Alt. Names/Synonyms: MGC72018; PABC1-interacting protein 2; PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2A; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; polyA-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.