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Protein Page:
PAIP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAIP2 Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Cellular Component: cytoplasm
Molecular Function: protein binding; translation repressor activity
Biological Process: negative regulation of translational initiation
Reference #:  Q9BPZ3 (UniProtKB)
Alt. Names/Synonyms: MGC72018; PABC1-interacting protein 2; PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2A; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; polyA-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2
Gene Symbols: PAIP2
Molecular weight: 14,984 Da
Basal Isoelectric point: 4.03  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAIP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MKDPsRSSTSPs
0 1 S12-p sRSSTSPsIINEDVI
0 37 Y34-p DDNPFAEyMWMENEE
0 5 K116-ub SNLNPNAkEFVPGVk
0 1 K123-ac kEFVPGVkyGNI___
0 2 K123-ub kEFVPGVkyGNI___
0 6 Y124-p EFVPGVkyGNI____
  mouse

 
S5 ___MKDPSRSSTSPS
S12 SRSSTSPSIINDDVI
Y34 EDNPFAEYMWMENEE
K116 SNLNPNAKEFVPGVK
K123 KEFVPGVKY______
K123 KEFVPGVKY______
Y124 EFVPGVKY_______
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