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PAIP2 (human)

Overview PAIP2 Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family. Note: This description may include information from UniProtKB. Protein type: RNA binding protein Cellular Component: cytoplasm Molecular Function: protein binding; translation repressor activity Biological Process: negative regulation of translational initiation Reference #:  Q9BPZ3 (UniProtKB) Alt. Names/Synonyms: MGC72018; PABC1-interacting protein 2; PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2A; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; polyA-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2 Gene Symbols: PAIP2 Molecular weight: 14,984 Da Basal Isoelectric point: 4.03  Predict pI for various phosphorylation states CST Pathways:  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PAIP2 1JGN - B=106-127 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S5-p	___MKDPsRSSTSPs
0	1		S12-p	sRSSTSPsIINEDVI
0	33		Y34-p	DDNPFAEyMWMENEE
0	5		K116-u	SNLNPNAkEFVPGVk
0	1		K123-a	kEFVPGVkyGNI___
0	2		K123-u	kEFVPGVkyGNI___
0	5		Y124-p	EFVPGVkyGNI____

	mouse
S5	___MKDPSRSSTSPS
S12	SRSSTSPSIINDDVI
Y34	EDNPFAEYMWMENEE
K116	SNLNPNAKEFVPGVK
K123	KEFVPGVKY______
K123	KEFVPGVKY______
Y124	EFVPGVKY_______

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