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Nur77 (human)

Overview Nur77 an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor; DNA binding protein; Apoptosis Cellular Component: nucleoplasm; transcription factor complex; nucleus Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; protein heterodimerization activity; steroid hormone receptor activity Biological Process: epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; cell migration during sprouting angiogenesis; induction of apoptosis; positive regulation of endothelial cell proliferation; gene expression; negative regulation of caspase activity; signal transduction Reference #:  P22736 (UniProtKB) Alt. Names/Synonyms: Early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; MGC9485; N10; NAK-1; NAK1; NGFIB; NP10; NR4A1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3; TR3 orphan receptor Gene Symbols: NR4A1 Molecular weight: 64,463 Da Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Nur77 2GBD - A/B/C/D=332-598 (human) 2QW4 - A/D/C/B=347-598 (human) 3V3E - A/B=351-598 (human) 3V3Q - A/B=351-598 (human) 1CIT - A=264-352 (rat) 1YJE - A=354-597 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2GBD 2QW4 3V3E 3V3Q  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: S351‑p cell cycle regulation: S95‑p, S140‑p, S431‑p cytoskeletal reorganization: S351‑p transcription, altered: S95‑p, S351‑p transcription, induced: S431‑p inhibition: S95‑p, S351‑p molecular association, regulation: S95‑p, S140‑p, S431‑p phosphorylation: S351‑p protein degradation: S95‑p protein stabilization: S95‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		S95-p	TSSSSATsPASASFK
3	0		S140-p	GSPCSAPsPStPSFQ
2	0		T143-p	CSAPsPStPSFQPPQ
1	0		S152-p	SFQPPQLsPWDGSFG
1	0		S341	KEVVRTDSLKGRRGR
7	2		S351-p	GRRGRLPsKPKQPPD
0	1		S360-p	PKQPPDAsPANLLTS
0	1		K381-u	DSGPSTAkLDYSKFQ
0	1		K386	TAkLDYSKFQELVLP
1	0		S431-p	IPGFAELsPADQDLL

	mouse
S97	SSSSSATSPASASFK
S142-p	GSPCSAPsPSTPNFQ
T145	CSAPsPSTPNFQPSQ
S154	NFQPSQLSPWDGSFG
S344	KEVVRTDSLKGRRGR
S354-p	GRRGRLPsKPKQPPD
S363	PKQPPDASPTNLLTS
K384	DSGPSTAKLDYSkFQ
K389-a	TAKLDYSkFQELVLP
C434	IPGFIELCPGDQDLL

	rat
S94	SSSSSATSPASASFK
S139	GSPCSAPSPPtPNFQ
T142-p	CSAPSPPtPNFQPSQ
S151	NFQPSQLSPWDGSFG
S340-p	KEVVRTDsLKGRRGR
S350-p	GRRGRLPsKPKQPPD
S359	PKQPPDASPTNLLTS
K380	DSGPNTAKLDYSKFQ
K385	TAKLDYSKFQELVLP
S430	IPGFIELSPGDQDLL

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