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Protein Page:
Nur77 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nur77 an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein; Apoptosis
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; protein heterodimerization activity; steroid hormone receptor activity
Biological Process: epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cell migration during sprouting angiogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; gene expression; steroid hormone mediated signaling; negative regulation of caspase activity; signal transduction
Reference #:  P22736 (UniProtKB)
Alt. Names/Synonyms: Early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; MGC9485; N10; NAK-1; NAK1; NGFIB; NP10; NR4A1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3; TR3 orphan receptor
Gene Symbols: NR4A1
Molecular weight: 64,463 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nur77

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S351‑p
cell cycle regulation: S95‑p, S140‑p, S431‑p
cytoskeletal reorganization: S351‑p
transcription, altered: S95‑p
transcription, induced: S431‑p
transcription, inhibited: S351‑p
activity, inhibited: S95‑p, S351‑p
molecular association, regulation: S95‑p, S140‑p, S431‑p
phosphorylation: S351‑p
protein degradation: S95‑p
protein stabilization: S95‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S95-p TSSSSATsPASASFK
3 0 S140-p GSPCSAPsPStPSFQ
2 0 T143-p CSAPsPStPSFQPPQ
1 0 S152-p SFQPPQLsPWDGSFG
0 1 T196-p FFSFSPPtGPSPsLA
0 1 S201-p PPtGPSPsLAQsPLK
0 1 S205-p PSPsLAQsPLKLFPS
0 1 S257-p VTSTKARsGAPGGsE
0 2 S263-p RsGAPGGsEGRCAVC
1 0 S341 KEVVRTDSLKGRRGR
7 3 S351-p GRRGRLPsKPKQPPD
0 2 S360-p PKQPPDAsPANLLTS
0 1 K381-ub DSGPSTAkLDYSKFQ
0 1 K386 TAkLDYSKFQELVLP
1 0 S431-p IPGFAELsPADQDLL
5095 : Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb
  mouse

 
S97 SSSSSATSPASASFK
S142-p GSPCSAPsPSTPNFQ
T145 CSAPsPSTPNFQPSQ
S154 NFQPSQLSPWDGSFG
T199 FFSFSPPTGPSPSLA
S204 PPTGPSPSLAQSSLK
S208 PSPSLAQSSLKLFPP
S260 VTSTKSRSGASGGSE
S266 RSGASGGSEGRCAVC
S344 KEVVRTDSLKGRRGR
S354-p GRRGRLPsKPKQPPD
S363 PKQPPDASPTNLLTS
K384 DSGPSTAKLDYSkFQ
K389-ac TAKLDYSkFQELVLP
C434 IPGFIELCPGDQDLL
5095 : Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb
  rat

 
S94 SSSSSATSPASASFK
S139 GSPCSAPSPPtPNFQ
T142-p CSAPSPPtPNFQPSQ
S151 NFQPSQLSPWDGSFG
T195 FFSFSPPTGPSPSLA
S200 PPTGPSPSLAQSSLK
S204 PSPSLAQSSLKLFPA
S256 VTSTKARSGSSGGSE
S262 RSGSSGGSEGRCAVC
S340-p KEVVRTDsLKGRRGR
S350-p GRRGRLPsKPKQPPD
S359 PKQPPDASPTNLLTS
K380 DSGPNTAKLDYSKFQ
K385 TAKLDYSKFQELVLP
S430 IPGFIELSPGDQDLL
5095 : Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb
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