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Protein Page:
FGF3 (human)

FGF3 Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia and microdontia (LAMM); also known as congenital deafness with inner ear agenesis, microtia and microdontia. LAMM consists of a unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia). Belongs to the heparin-binding growth factors family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: Golgi apparatus; extracellular region
Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of cardiac muscle development; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; thymus development; nerve growth factor receptor signaling pathway; semicircular canal morphogenesis; signal transduction; cell-cell signaling; induction of an organ; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; otic vesicle formation
Reference #:  P11487 (UniProtKB)
Alt. Names/Synonyms: FGF-3; FGF3; Fibroblast growth factor 3; fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog); HBGF-3; Heparin-binding growth factor 3; INT-2 proto-oncogene protein; INT2; murine mammary tumor virus integration site 2, mouse; oncogene INT2; Proto-oncogene Int-2; V-INT2 murine mammary tumor virus integration site oncogene homolog
Gene Symbols: FGF3
Molecular weight: 26,887 Da
Basal Isoelectric point: 10.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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