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Protein Page:
DVL3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DVL3 a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Cellular Component: cell cortex
Molecular Function: signal transducer activity; protein binding; protease binding; protein heterodimerization activity; frizzled binding; beta-catenin binding; receptor binding
Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; convergent extension; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation
Reference #:  Q92997 (UniProtKB)
Alt. Names/Synonyms: dishevelled 3 (homologous to Drosophila dsh); dishevelled, dsh homolog 3 (Drosophila); Dishevelled-3; DSH homolog 3; DVL3; KIAA0208; Segment polarity protein dishevelled homolog DVL-3
Gene Symbols: DVL3
Molecular weight: 78,055 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DVL3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T15-p YHLDGQEtPYLVKLP
1 0 R27-me KLPLPAErVTLADFK
0 1 S41-p KGVLQRPsYKFFFKs
1 4 S48-p sYKFFFKsMDDDFGV
1 0 S61-p GVVKEEIsDDNAKLP
1 0 S116-p IGDSRPPsFHPHAGG
1 3 S125-p HPHAGGGsQENLDND
1 0 T133-p QENLDNDtEtDsLVs
1 0 T135-p NLDNDtEtDsLVsAQ
1 0 S137-p DNDtEtDsLVsAQRE
1 0 S140-p tEtDsLVsAQRERPR
1 0 S175-p REPGGYDsSSTLMSS
2 3 S192-p ETTSFFDsDEDDsTS
1 0 S197-p FDsDEDDsTSRFsss
2 1 S202-p DDsTSRFssstEQss
2 2 S203-p DsTSRFssstEQssA
2 0 S204-p sTSRFssstEQssAs
1 0 T205-p TSRFssstEQssAsr
2 0 S208-p FssstEQssAsrLMR
1 2 S209-p ssstEQssAsrLMRR
1 0 S211-p stEQssAsrLMRRHK
1 0 R212-me tEQssAsrLMRRHKR
1 0 S232-p KVSRIERsSsFSsIT
1 0 S234-p SRIERsSsFSsITDS
1 0 S237-p ERsSsFSsITDSTMs
0 1 S244-p sITDSTMsLNIITVT
1 0 S280-p DGGIYIGsIMkGGAV
0 3 K283-ub IYIGsIMkGGAVAAD
1 1 S311-p EINFENMsNDDAVRV
0 1 S340-p VAKCWDPsPrGCFtL
1 0 R342-me KCWDPsPrGCFtLPR
1 2 T346-p PsPrGCFtLPRsEPI
1 0 S350-p GCFtLPRsEPIRPID
1 0 S421-p AIVKAMAsPESGLEV
1 0 S512-p SLHDHDGsSGAsDQD
1 0 S516-p HDGsSGAsDQDTLAP
1 0 S564-p GYSYGGGsAssQHsE
1 0 S566-p SYGGGsAssQHsEGs
1 0 S567-p YGGGsAssQHsEGsR
1 0 S570-p GsAssQHsEGsRssG
1 0 S573-p ssQHsEGsRssGsNR
1 0 S575-p QHsEGsRssGsNRSG
1 0 S576-p HsEGsRssGsNRSGS
1 0 S578-p EGsRssGsNRSGSDR
0 1 S596-p KDPKAGDsKsGGsGs
0 1 S598-p PKAGDsKsGGsGsEs
1 1 S601-p GDsKsGGsGsEsDHt
1 2 S603-p sKsGGsGsEsDHttR
1 0 S605-p sGGsGsEsDHttRss
0 1 T608-p sGsEsDHttRssLRG
0 1 T609-p GsEsDHttRssLRGP
1 0 S611-p EsDHttRssLRGPRE
1 1 S612-p sDHttRssLRGPRER
1 0 S622-p GPRERAPsERsGPAA
1 0 S625-p ERAPsERsGPAASEH
1 0 S633-p GPAASEHsHRsHHsL
1 0 S636-p ASEHsHRsHHsLAss
1 0 S639-p HsHRsHHsLAssLRS
1 0 S642-p RsHHsLAssLRSHHT
1 0 S643-p sHHsLAssLRSHHTH
1 0 S689-p PPGRDLAsVPPELTA
1 1 S697-p VPPELTAsrQsFRMA
1 0 R698-me PPELTAsrQsFRMAM
1 0 R698-m2 PPELTAsrQsFRMAM
1 0 S700-p ELTAsrQsFRMAMGN
  mouse

 
T15 YHLDGQETPYLVKLP
R27 KLPLPAERVTLADFK
S41 KGVLQRPSYKFFFKs
S48-p SYKFFFKsMDDDFGV
S61 GVVKEEISDDNAKLP
S116 IGDSRPPSFHPHASG
S125 HPHASGGSQENLDND
T133 QENLDNDTETDSLVS
T135 NLDNDTETDSLVSAQ
S137 DNDTETDSLVSAQRE
S140 TETDSLVSAQRERPR
S175 REPGGYDSSSTLMSS
S192 ETTSFFDSDEDDSTS
S197 FDSDEDDSTSRFSsS
S202 DDSTSRFSsSTEQSS
S203-p DSTSRFSsSTEQSSA
S204 STSRFSsSTEQSSAS
T205 TSRFSsSTEQSSASR
S208 FSsSTEQSSASRLMR
S209 SsSTEQSSASRLMRR
S211 STEQSSASRLMRRHK
R212 TEQSSASRLMRRHKR
S232 KVSRIERSSSFSSIT
S234 SRIERSSSFSSITDS
S237 ERSSSFSSITDSTMS
S244 SITDSTMSLNIITVT
S280 DGGIYIGSIMKGGAV
K283 IYIGSIMKGGAVAAD
S311-p EINFENMsNDDAVRV
S340 VAKCWDPSPRGCFTL
R342 KCWDPSPRGCFTLPR
T346 PSPRGCFTLPRSEPI
S350 GCFTLPRSEPIRPID
S421 AIVKAMASPESGLEV
S512 SLHDHDGSSGASDQD
S516 HDGSSGASDQDTLAP
S564 GYSYGGGSASSQHSE
S566 SYGGGSASSQHSEGS
S567 YGGGSASSQHSEGSR
S570 GSASSQHSEGSRSSG
S573 SSQHSEGSRSSGSNR
S575 QHSEGSRSSGSNRSG
S576 HSEGSRSSGSNRSGS
S578 EGSRSSGSNRSGSDR
S596 KDPKAGDSKSGGSGS
S598 PKAGDSKSGGSGSES
S601 GDSKSGGSGSESDHT
S603 SKSGGSGSESDHTTR
S605 SGGSGSESDHTTRSS
T608 SGSESDHTTRSSLRG
T609 GSESDHTTRSSLRGP
S611 ESDHTTRSSLRGPRE
S612 SDHTTRSSLRGPRER
S622 GPRERAPSERSGPAA
S625 ERAPSERSGPAASEH
S633 GPAASEHSHRSHHSL
S636 ASEHSHRSHHSLTSS
S639 HSHRSHHSLTSSLRS
S642 RSHHSLTSSLRSHHT
S643 SHHSLTSSLRSHHTH
S689 PPGRDLASVPPELTA
S697-p VPPELTAsRQsFRMA
R698 PPELTAsRQsFRMAM
R698 PPELTAsRQsFRMAM
S700-p ELTAsRQsFRMAMGN
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