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DVL3 (human)

Overview DVL3 a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis Cellular Component: cell cortex Molecular Function: signal transducer activity; protein binding; protease binding; protein heterodimerization activity; frizzled binding; beta-catenin binding; receptor binding Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; convergent extension; positive regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin Reference #:  Q92997 (UniProtKB) Alt. Names/Synonyms: dishevelled 3 (homologous to Drosophila dsh); dishevelled, dsh homolog 3 (Drosophila); Dishevelled-3; DSH homolog 3; DVL3; KIAA0208; Segment polarity protein dishevelled homolog DVL-3 Gene Symbols: DVL3 Molecular weight: 78,055 Da Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states CST Pathways:  Hippo Signaling  |  mTOR Signaling  |  Regulation of Microtubule Dynamics  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DVL3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		R27-m	KLPLPAErVTLADFK
0	1		S41-p	KGVLQRPsYKFFFKs
0	2		S48-p	sYKFFFKsMDDDFGV
0	2		S125-p	HPHAGGGsQENLDND
1	2		S192-p	ETTSFFDsDEDDSTS
1	1		S202-p	DDSTSRFsssTEQsS
1	1		S203-p	DSTSRFsssTEQsSA
1	0		S204-p	STSRFsssTEQsSAS
1	0		S208-p	FsssTEQsSASrLMR
1	0		R212-m	TEQsSASrLMRRHKR
0	1		S244-p	SITDSTMsLNIITVT
0	3		K283-u	IYIGSIMkGGAVAAD
0	1		S311	EINFENMSNDDAVRV
1	0		R342-m	KCWDPSPrGCFtLPR
1	1		T346-p	PSPrGCFtLPRSEPI
0	1		S596-p	KDPKAGDsKSGGSGs
0	1		S603-p	sKSGGSGsESDHttR
0	1		T608-p	SGsESDHttRSsLRG
0	1		T609-p	GsESDHttRSsLRGP
0	1		S612-p	SDHttRSsLRGPRER
1	0		R698-m	PPELTASrQsFRMAM
1	0		R698-m2	PPELTASrQsFRMAM
1	0		S700-p	ELTASrQsFRMAMGN

	mouse
R27	KLPLPAERVTLADFK
S41	KGVLQRPSYKFFFKs
S48-p	SYKFFFKsMDDDFGV
S125	HPHASGGSQENLDND
S192	ETTSFFDSDEDDSTS
S202	DDSTSRFSsSTEQSS
S203-p	DSTSRFSsSTEQSSA
S204	STSRFSsSTEQSSAS
S208	FSsSTEQSSASRLMR
R212	TEQSSASRLMRRHKR
S244	SITDSTMSLNIITVT
K283	IYIGSIMKGGAVAAD
S311-p	EINFENMsNDDAVRV
R342	KCWDPSPRGCFTLPR
T346	PSPRGCFTLPRSEPI
S596	KDPKAGDSKSGGSGS
S603	SKSGGSGSESDHTTR
T608	SGSESDHTTRSSLRG
T609	GSESDHTTRSSLRGP
S612	SDHTTRSSLRGPRER
R698	PPELTASRQsFRMAM
R698	PPELTASRQsFRMAM
S700-p	ELTASRQsFRMAMGN

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