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Overview |
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CD82
a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Cell surface |
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Cellular Component: integral to plasma membrane; plasma membrane
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Molecular Function: protein binding
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Reference #:
P27701 (UniProtKB)
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| Alt. Names/Synonyms: 4F9; C33; C33 antigen; CD82; CD82 antigen; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); CD82 molecule; GR15; IA4; Inducible membrane protein R2; KAI1; kangai 1 (suppression of tumorigenicity 6, prostate; Metastasis suppressor Kangai-1; R2; R2 leukocyte antigen; SAR2; ST6; suppression of tumorigenicity 6; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; TSPAN27 |
| Gene Symbols: CD82 |
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Molecular weight: 29,626 Da
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Basal Isoelectric point: 5.14
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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Select Structure to View Below |
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CD82 |
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