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Protein Page:
CD82 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD82 a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell surface
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding
Reference #:  P27701 (UniProtKB)
Alt. Names/Synonyms: 4F9; C33; C33 antigen; CD82; CD82 antigen; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); CD82 molecule; GR15; IA4; Inducible membrane protein R2; KAI1; kangai 1 (suppression of tumorigenicity 6, prostate; Metastasis suppressor Kangai-1; R2; R2 leukocyte antigen; SAR2; ST6; suppression of tumorigenicity 6; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; TSPAN27
Gene Symbols: CD82
Molecular weight: 29,626 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD82

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K114-ub YFNMGKLkQEMGGIV
0 1 S258-p CLCRHVHsEDysKVP
0 100 Y261-p RHVHsEDysKVPKy_
0 9 S262-p HVHsEDysKVPKy__
0 31 Y267-p DysKVPKy_______
  mouse

 
K114 YFNADKLKKEMGNTV
S257 CLCRYIHSEDySKVP
Y260-p RYIHSEDySKVPKY_
S261 YIHSEDySKVPKY__
Y266 DySKVPKY_______
  rat

 
K114 YFNANKLKQEMGNTV
S257 CLCRYIHSEDYSKVP
Y260 RYIHSEDYSKVPKY_
S261 YIHSEDYSKVPKY__
Y266 DYSKVPKY_______
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