Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
GLI2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLI2 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Cellular Component: membrane; cytoplasm; motile primary cilium; nuclear speck; nucleus; cilium
Molecular Function: protein binding; nucleic acid binding; DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding; chromatin binding; transcription factor activity
Biological Process: neural tube development; developmental growth; anatomical structure development; positive regulation of transcription, DNA-dependent; heart development; negative regulation of chondrocyte differentiation; chondrocyte differentiation; anatomical structure formation; kidney development; embryonic gut development; hindbrain development; transcription, DNA-dependent; notochord regression; osteoblast development; cerebellar cortex morphogenesis; branching morphogenesis of a tube; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; tube development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; axon guidance; ventral midline development; spinal cord ventral commissure morphogenesis; spinal cord dorsal/ventral patterning; negative regulation of transcription from RNA polymerase II promoter; mammary gland development; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation; smoothened signaling pathway involved in ventral spinal cord interneuron specification; skeletal development; proximal/distal pattern formation; dorsoventral neural tube patterning; smoothened signaling pathway; floor plate formation; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; in utero embryonic development; ventral spinal cord development; spinal cord motor neuron differentiation; pattern specification process; odontogenesis of dentine-containing teeth; osteoblast differentiation; cell proliferation; dorsal/ventral pattern formation; pituitary gland development; epidermal cell differentiation; hindgut morphogenesis; positive regulation of neuron differentiation; positive regulation of DNA replication; regulation of smoothened signaling pathway; lung development
Reference #:  Q0VGT2 (UniProtKB)
Alt. Names/Synonyms: AW546128; GLI-Kruppel family member GLI2; Gli2; Tax helper protein
Gene Symbols: Gli2
Molecular weight: 165,031 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below

GLI2

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 P8 METSAPAPALEKKEA
0 1 L10 TSAPAPALEKKEAKS
0 3 S128 HMEHYLRSVHSSPTL
0 1 S131 HYLRSVHSSPTLSMI
0 1 S132 YLRSVHSSPTLSMIS
0 1 S139 SPTLSMISAARGLSP
0 2 S145 ISAARGLSPADVAHE
0 4 T220 RFSSPRVTPRLSRKR
0 3 S230 LSRKRALSISPLSDA
0 3 S232 RKRALSISPLSDASL
0 1 S235 ALSISPLSDASLDLQ
0 1 S238 ISPLSDASLDLQRMI
0 1 S251 MIRTSPNSLVAYINN
0 1 K373 ITIHKRSKVKTEAEG
1 2 S385-p AEGLRPAsPLGLTQE
0 1 S539 KHQNRTHSNEKPYIC
0 1 Y544 THSNEKPYICKIPGC
0 1 A600 NGDNEASAEPGGRGP
0 1 S610 GGRGPEESVEASSTS
0 1 S614 PEESVEASSTSHTVE
1 0 K630-sm CLHIKAIkTESSGLC
1 0 K716-sm VHRFEQLkREKLKSL
1 0 K740-ac APHTRNTkLPPLPVN
1 3 S789-p QLQERRDsSTSTMSs
0 1 S796-p sSTSTMSsAYTVSRR
0 1 T799 STMSsAYTVSRRSsG
0 2 S801 MSsAYTVSRRSsGIS
1 4 S805-p YTVSRRSsGISPYFS
1 2 S817-p YFSSRRSsEASPLGG
0 1 S820 SRRSsEASPLGGLRP
0 1 S831-p GLRPHNAsSADSYDP
0 1 S840 ADSYDPISTDASRRS
0 1 T841 DSYDPISTDASRRSs
1 0 S848-p TDASRRSsEASQCSG
0 1 S851 SRRSsEASQCSGGGP
1 1 T885-p ATGGPPPtPLPGLDR
0 1 H915 ALPGACPHPLGPRRG
1 3 S923-p PLGPRRGsDGPTYSH
1 6 S956-p NSSTRRAsDPVRRPD
0 3 S975 PRVQRFHSTHNMNPG
0 1 T976 RVQRFHSTHNMNPGS
0 1 S997 RRGLHVQSHPSVDSN
0 1 T1006-p PSVDSNLtRNAYsPR
1 0 S1011-p NLtRNAYsPRPPSIN
0 5 S1016 AYsPRPPSINENVVM
0 1 S1087 PENSKLPSPGLQGHR
0 1 S1180 NPQSVQSSSGGLDST
  human

► Hide Isoforms
 
T8-p METSASAtAsEKQEA
S10-p TSASAtAsEKQEAKS
S132-p HMEHYLRsVHssPTL
S135-p HYLRsVHssPTLSMI
S136-p YLRsVHssPTLSMIs
S143-p sPTLSMIsAARGLsP
S149-p IsAARGLsPADVAQE
T224-p RFSSPRVtPRLSRKR
S234-p LSRKRALsIsPLsDA
S236-p RKRALsIsPLsDAsL
S239-p ALsIsPLsDAsLDLQ
S242-p IsPLsDAsLDLQRMI
S255-p MIRTSPNsLVAYINN
K376 VAIHKRSKVKTEPEG
S388-p PEGLRPAsPLALTQG
S559 KHQNRTHSNEKPYIC
Y564 THSNEKPYICKIPGC
T620 NGDSEAGTEPGGPES
S627 TEPGGPESTEASSTS
S631 GPESTEASSTSQAVE
K647 CLHVRAIKTESSGLC
K733 MHRFEQLKKEKLKSL
K757-ac TPHTRNTkLPPLPGS
S808-p QLQERRDsSTSTVSS
S815 sSTSTVSSAYtVsRR
T818-p STVSSAYtVsRRSsG
S820-p VSSAYtVsRRSsGIS
S824-p YtVsRRSsGISPYFS
S836-p YFSSRRSsEAsPLGA
S839-p SRRSsEAsPLGAGRP
S850 AGRPHNASSADSYDP
S859-p ADSYDPIstDASRRS
T860-p DSYDPIstDASRRSs
S867-p tDASRRSsEAsQCSG
S870-p SRRSsEAsQCSGGSG
T903 ATGGPPPTPLPGLER
R933 TLPAGCPRPLGPRRG
S941-p PLGPRRGsDGPTYGH
S970-p GGGARRAsDPVRRPD
S989-p PRVQRFHstHNVNPG
T990-p RVQRFHstHNVNPGP
S1011-p RRGLRLQsHPSTDGG
A1020 PSTDGGLARGAYSPR
S1025 GLARGAYSPRPPsIS
S1030-p AYSPRPPsISENVAM
S1101-p SDNPRLPsPGLHGQR
S1194 SPQGLQASPGGLDST
  GLI2 iso1  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K48-ac VAIHKRSkVKTEPEG
S60 PEGLRPASPLALTQG
S231-p KHQNRTHsNEKPyIC
Y236-p THsNEKPyICKIPGC
T292-p NGDSEAGtEPGGPEs
S299-p tEPGGPEsTEAsSTS
S303-p GPEsTEAsSTSQAVE
K319 CLHVRAIKTESSGLC
K405 MHRFEQLKKEKLKSL
K429 TPHTRNTKLPPLPGS
S480 QLQERRDSSTSTVSS
S487 SSTSTVSSAYTVSRR
T490 STVSSAYTVSRRSSG
S492 VSSAYTVSRRSSGIS
S496 YTVSRRSSGISPYFS
S508 YFSSRRSSEASPLGA
S511 SRRSSEASPLGAGRP
S522 AGRPHNASSADSYDP
S531 ADSYDPISTDASRRS
T532 DSYDPISTDASRRSS
S539 TDASRRSSEASQCSG
S542 SRRSSEASQCSGGSG
T575 ATGGPPPTPLPGLER
R605-m2 TLPAGCPrPLGPRRG
S613 PLGPRRGSDGPTYGH
S642 GGGARRASDPVRRPD
S661 PRVQRFHSTHNVNPG
T662 RVQRFHSTHNVNPGP
S683-p RRGLRLQsHPSTDGG
A692 PSTDGGLARGAYSPR
S697 GLARGAYSPRPPsIS
S702-p AYSPRPPsISENVAM
S773 SDNPRLPSPGLHGQR
S866-p SPQGLQAsPGGLDST
  GLI2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K48 VAIHKRSKVKTEPEG
S60-p PEGLRPAsPLALTQE
S214 KHQNRTHSNEKPYIC
Y219 THSNEKPYICKIPGC
T275 NGDSEAGTEPGGPES
S282 TEPGGPESTEASSTS
S286 GPESTEASSTSQAVE
K302 CLHVRAIKTESSGLC
K388 MHRFEQLKKEKLKSL
K412 TPHTRNTKLPPLPGS
S463 QLQERRDSSTSTVSS
S470 SSTSTVSSAYTVSRR
T473 STVSSAYTVSRRSSG
S475 VSSAYTVSRRSSGIS
S479 YTVSRRSSGISPYFS
S491 YFSSRRSSEASPLGA
S494 SRRSSEASPLGAGRP
S505 AGRPHNASSADSYDP
S514 ADSYDPISTDASRRS
T515 DSYDPISTDASRRSS
S522 TDASRRSSEASQCSG
S525 SRRSSEASQCSGGSG
T558 ATGGPPPTPLPGLER
R588 TLPAGCPRPLGPRRG
S596 PLGPRRGSDGPTYGH
S625 GGGARRASDPVRRPD
S644 PRVQRFHSTHNVNPG
T645 RVQRFHSTHNVNPGP
S666 RRGLRLQSHPSTDGG
A675 PSTDGGLARGAYSPR
S680 GLARGAYSPRPPSIS
S685 AYSPRPPSISENVAM
S756 SDNPRLPSPGLHGQR
S849 SPQGLQASPGGLDST
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.